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09-SEPTEMBER-2008 19:33:10 - Peroxynitrite The structure of the peroxynitrite anion The structure of the peroxynitrite anion Peroxynitrite is the anion with the formula ONOO-. It is an unstable valence isomer of nitrate, NO3-, which has the same formula but a different structure. Although peroxynitrous acid is highly reactive, its conjugate base peroxynitrite is stable in basic solution.1 It is prepared by the reaction of hydrogen peroxide with nitrite: H2O2 + NO2- → ONOO- + H2O Peroxynitrite is an oxidant and nitrating agent. Because of its oxidizing properties, peroxynitrite can damage a wide array of molecules in cells, including DNA and proteins. Formation of peroxynitrite in vivo has been ascribed to the reaction of the free radical superoxide with the free radical nitric oxide2: ·O2- + ·NO → ONO2- The resultant paring of these two free radicals results in peroxynitrite, a molecule which is itself not a free radical, but which is a powerful oxidant. In the laboratory, a solution of peroxynitrite can be prepared by treating acidified hydrogen peroxide with a solution of sodium nitrite, followed by rapid addition of NaOH. Its concentration is indicated by the absorbance at 302 nm pH 12, λ302 = 1670 M-1 cm-1.3 As a nucleophile ONOO- reacts nucleophilically with carbon dioxide. In vivo, the concentration of carbon dioxide is about 1 mM, and its reaction with ONOO- occurs quickly. Thus, under physiological conditions, the reaction of ONOO- with carbon dioxide to form nitrosoperoxycarbonate ONOOCO2- is by far the predominant pathway for ONOO-. ONOOCO2- homolyzes to form carbonate radical and nitrogen dioxide, again as a pair of caged radicals. Approximately 66% of the time, these two radicals recombine to form carbon dioxide and nitrate. The other 33% of the time, these two radicals escape the solvent cage and become free radicals. It is these radicals carbonate radical and nitrogen dioxide that are believed to cause peroxynitrite-related cellular damage. Peroxynitrous acid The conjugate acid of ONOO- is peroxynitrous acid ONOOH or phonetically HOONO, pronounced hoo-noh, which has a pKa of ~6.8. HOONO can homolyze to form nitrogen dioxide and hydroxyl radical as a pair of caged radicals. Approximately 66% of the time, these two radicals undergo electron transfer to form nitronium ion and hydroxide. The other 33% of the time, the two species escape the solvent cage as free radicals. OH· + NO2 � HOONO → OH- + NO2+ HOONO is thought to be important in atmospheric chemistry. References ^ Holleman, A. F.; Wiberg, E. Inorganic Chemistry Academic Press: San Diego, 2001. ISBN 0-12-352651-5. ^ Pacher, P.; Beckman, J. S.; Liaudet, L.; Nitric Oxide and Peroxynitrite: in Health and disease Physiological Reviews 2007, volume 871, page 315-424. PMID 17237348 ^ Beckman, J. S.; Koppenol, W. H. Nitric Oxide, Superoxide, and Peroxynitrite: the Good, the Bad, and Ugly American Journal of Physiology- Cell Physiology 1996, volume 271, page C1424-C1437. This chemistry article is a stub. Retrieved from http://en..org/wiki/Peroxynitrite Categories: Atmospheric chemistry | Toxins | Chemistry stubs Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Français Italiano This page was last modified on 19 March 2008, at 04:0
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