Sierra Acai Company
Sierra Acai Company
Open 7 Days a Week
MonaVie Independent Distributor
Distributor Training
Shop Online
Enroll Now
Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
Friends
Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
14-September-2008 18:02:41 - receptor Melanocortin 2 receptor adrenocorticotropic hormone Identifiers Symbols MC2R; ACTHR; MGC125798 External IDs OMIM: 607397 MGI: 96928 HomoloGene: 444 Gene ontology Molecular function: rhodopsin-like receptor activity receptor activity adrenocorticotropin receptor activity Cellular component: integral to plasma membrane membrane Biological process: signal transduction G-protein signaling, coupled to cyclic nucleotide second messenger RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 4158 17200 Ensembl ENSG00000185231 ENSMUSG00000045569 Uniprot Q01718 Q544P9 Refseq NM_000529 mRNA NP_000520 protein NM_008560 mRNA NP_032586 protein Location Chr 18: 13.87 - 13.91 Mb Chr 18: 68.53 - 68.55 Mb Pubmed search 1 2 The ACTH receptor is a type of melanocortin receptor type 2 which is specific for ACTH.1 It is found in the zona fasciculata of the adrenal cortex and stimulates production of cortisol. By contrast, aldosterone production from the zona glomerulosa is stimulated primarily by angiotensin II. Contents 1 See also 2 References 3 Further reading 4 See also 5 External links See also Melanocortin receptor References ^ Beuschlein F, Fassnacht M, Klink A, Allolio B, Reincke M 2001. ACTH-receptor expression, regulation and role in adrenocortial tumor formation. Eur. J. Endocrinol. 144 3: 199-206. doi:10.1530/eje.0.1440199. PMID 11248736. Further reading Cone RD, Mountjoy KG, Robbins LS, et al. 1993. Cloning and functional characterization of a family of receptors for the melanotropic peptides.. Ann. N. Y. Acad. Sci. 680: 342-63. PMID 8390157. Allolio B, Reincke M 1997. Adrenocorticotropin receptor and adrenal disorders.. Horm. Res. 47 4-6: 273-8. PMID 9167964. Tatro JB 1997. Receptor biology of the melanocortins, a family of neuroimmunomodulatory peptides.. Neuroimmunomodulation 3 5: 259-84. PMID 9218248. Mountjoy KG, Robbins LS, Mortrud MT, Cone RD 1992. The cloning of a family of genes that encode the melanocortin receptors.. Science 257 5074: 1248-51. PMID 1325670. Clark AJ, McLoughlin L, Grossman A 1993. Familial glucocorticoid deficiency associated with point mutation in the adrenocorticotropin receptor.. Lancet 341 8843: 461-2. PMID 8094489. Tsigos C, Arai K, Hung W, Chrousos GP 1993. Herary isolated glucocorticoid deficiency is associated with abnormalities of the adrenocorticotropin receptor gene.. J. Clin. Invest. 92 5: 2458-61. PMID 8227361. Gantz I, Tashiro T, Barcroft C, et al. 1994. Localization of the genes encoding the melanocortin-2 adrenocorticotropic hormone and melanocortin-3 receptors to chromosomes 18p11.2 and 20q13.2-q13.3 by fluorescence in situ hybridization.. Genomics 18 1: 166-7. doi:10.1006/geno.1993.1448. PMID 8276410. Gantz I, Konda Y, Tashiro T, et al. 1993. Molecular cloning of a novel melanocortin receptor.. J. Biol. Chem. 268 11: 8246-50. PMID 8463333. Naville D, Barjhoux L, Jaillard C, et al. 1996. Demonstration by transfection studies that mutations in the adrenocorticotropin receptor gene are one cause of the herary syndrome of glucocorticoid deficiency.. J. Clin. Endocrinol. Metab. 81 4: 1442-8. PMID 8636348. Naville D, Jaillard C, Barjhoux L, et al. 1997. Genomic structure and promoter characterization of the human ACTH receptor gene.. Biochem. Biophys. Res. Commun. 230 1: 7-12. doi:10.1006/bbrc.1996.5911. PMID 9020063. Yang YK, Ollmann MM, Wilson BD, et al. 1997. Effects of recombinant agouti-signaling protein on melanocortin action.. Mol. Endocrinol. 11 3: 274-80. PMID 9058374. Naville D, Barjhoux L, Jaillard C, et al. 1997. Stable expression of normal and mutant human ACTH receptor: study of ACTH binding and coupling to adenylate cyclase.. Mol. Cell. Endocrinol. 129 1: 83-90. PMID 9175632. Penhoat A, Naville D, Jaillard C, et al. 1997. Presence of multiple functional polyadenylation signals in the 3'-untranslated region of human corticotropin receptor cDNA.. Biochim. Biophys. Acta 1356 3: 249-52. PMID 9194567. Ishii T, Ogata T, Sasaki G, et al. 2000. Novel mutations of the ACTH receptor gene in a female adult patient with adrenal unresponsiveness to ACTH.. Clin. Endocrinol. Oxf 53 3: 389-92. PMID 10971458. Flück CE, Martens JW, Conte FA, Miller WL 2002. Clinical, genetic, and functional characterization of adrenocorticotropin receptor mutations using a novel receptor assay.. J. Clin. Endocrinol. Metab. 87 9: 4318-23. PMID 12213892. Swords FM, Baig A, Malchoff DM, et al. 2003. Impaired desensitization of a mutant adrenocorticotropin receptor associated with apparent constitutive activity.. Mol. Endocrinol. 16 12: 2746-53. PMID 12456795. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. See also melanocortin Roy et al. 2007 Differential regulation of the human ACTH receptor MC2R by human MRAP isoforms alpha and beta in isogenic HEK 293 cells. Mol Endocrinol 21:1656-1669 External links IUPHAR GPCR Database - Melanocortin MC2 receptor MeSH MC2+Receptor This transmembrane receptor-related article is a stub. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/ACTH_receptor Categories: Genes on chromosome 18 | Human proteins | Receptors | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 04:07
39 Reasons to Drink Acai Juice Every Day
What is MonaVie - Watch the 8-minute video
Discovering MonaVie Video
The Power of You Video
Effects of MonaVie Active on Antioxidant Capacity in Humans
Log into your Wholesale MonaVie Account
So many of us do not eat a balanced diet, get enough sleep, have too much stress, or are impacted with toxins and pollutants. Drinking 2 ounces of MonaVie twice a day will help your body detoxify as well as build your immune system. Its the smartest thing you can do for yourself, so start today. Buying MonaVie through our company guarantees you support 7 days a week and, if you would like to share MonaVie with your family and friends we will guide you from start to finish.
1. Click on Enroll Now (30 - 55% off retail price)
2. Pay $39 for your Wholesale ID number.
3. NO minimum order required.
4. MonaVie is delivered to your door in 3 to 5 days.