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14-September-2008 18:02:48 - 9 ADAM metallopeptidase domain 19 meltrin beta Identifiers Symbols ADAM19; FKSG34; MADDAM; MLTNB External IDs OMIM: 603640 MGI: 105377 HomoloGene: 74925 Gene ontology Molecular function: metalloendopeptidase activity zinc ion binding metal ion binding Cellular component: membrane integral to membrane Biological process: membrane protein ectodomain proteolysis heart development RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 8728 11492 Ensembl ENSG00000135074 ENSMUSG00000011256 Uniprot Q9H013 Q3UH67 Refseq NM_023038 mRNA NP_075525 protein XM_981888 mRNA XP_986982 protein Location Chr 5: 156.84 - 156.94 Mb Chr 11: 45.9 - 45.99 Mb Pubmed search 1 2 ADAM metallopeptidase domain 19 meltrin beta, also known as ADAM19, is a human gene.1 This gene encodes a member of the ADAM a disintegrin and metalloprotease domain family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has also been demonstrated to be an active metalloproteinase, which may be involved in normal physiological and pathological processes such as cells migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. Alternative splicing results in two transcript variants.1 References ^ a b Entrez Gene: ADAM19 ADAM metallopeptidase domain 19 meltrin beta. Further reading Adams MD, Kerlavage AR, Fields C, Venter JC 1993. 3,400 new expressed sequence tags identify diversity of transcripts in human brain.. Nat. Genet. 4 3: 256-67. doi:10.1038/ng0793-256. PMID 8358434. Inoue D, Reid M, Lum L, et al. 1998. Cloning and initial characterization of mouse meltrin beta and analysis of the expression of four metalloprotease-disintegrins in bone cells.. J. Biol. Chem. 273 7: 4180-7. PMID 9461614. Hirohata S, Seldin MF, Apte SS 1999. Chromosomal assignment of two ADAM genes, TACE ADAM17 and MLTNB ADAM19, to human chromosomes 2 and 5, respectively, and of Mltnb to mouse chromosome 11.. Genomics 54 1: 178-9. doi:10.1006/geno.1998.5544. PMID 9806848. Fritsche J, Moser M, Faust S, et al. 2000. Molecular cloning and characterization of a human metalloprotease disintegrin--a novel marker for dendritic cell differentiation.. Blood 96 2: 732-9. PMID 10887142. Shirakabe K, Wakatsuki S, Kurisaki T, Fujisawa-Sehara A 2001. Roles of Meltrin beta /ADAM19 in the processing of neuregulin.. J. Biol. Chem. 276 12: 9352-8. doi:10.1074/jbc.M007913200. PMID 11116142. Wei P, Zhao YG, Zhuang L, et al. 2001. Expression and enzymatic activity of human disintegrin and metalloproteinase ADAM19/meltrin beta.. Biochem. Biophys. Res. Commun. 280 3: 744-55. doi:10.1006/bbrc.2000.4200. PMID 11162584. Zhao YG, Wei P, Sang QX 2001. Inhibitory antibodies against endopeptidase activity of human adamalysin 19.. Biochem. Biophys. Res. Commun. 289 1: 288-94. doi:10.1006/bbrc.2001.5958. PMID 11708814. Kang T, Zhao YG, Pei D, et al. 2002. Intracellular activation of human adamalysin 19/disintegrin and metalloproteinase 19 by furin occurs via one of the two consecutive recognition sites.. J. Biol. Chem. 277 28: 25583-91. doi:10.1074/jbc.M203532200. PMID 12006600. Díaz-Rodríguez E, Montero JC, Esparís-Ogando A, et al. 2002. Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding.. Mol. Biol. Cell 13 6: 2031-44. doi:10.1091/mbc.01-11-0561. PMID 12058067. Kang T, Park HI, Suh Y, et al. 2003. Autolytic processing at Glu586-Ser587 within the cysteine-rich domain of human adamalysin 19/disintegrin-metalloproteinase 19 is necessary for its proteolytic activity.. J. Biol. Chem. 277 50: 48514-22. doi:10.1074/jbc.M208961200. PMID 12393862. Huang L, Feng L, Yang L, et al. 2003. Screen and identification of proteins interacting with ADAM19 cytoplasmic tail.. Mol. Biol. Rep. 29 3: 317-23. PMID 12463424. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Abram CL, Seals DF, Pass I, et al. 2003. The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells.. J. Biol. Chem. 278 19: 16844-51. doi:10.1074/jbc.M300267200. PMID 12615925. Chesneau V, Becherer JD, Zheng Y, et al. 2003. Catalytic properties of ADAM19.. J. Biol. Chem. 278 25: 22331-40. doi:10.1074/jbc.M302781200. PMID 12682046. Ota T, Suzuki Y, Nishikawa T, et al. 2004. Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat. Genet. 36 1: 40-5. doi:10.1038/ng1285. PMID 14702039. Kang T, Tschesche H, Amy Sang QX 2004. Evidence for disulfide involvement in the regulation of intramolecular autolytic processing by human adamalysin19/ADAM19.. Exp. Cell Res. 298 1: 285-95. doi:10.1016/j.yexcr.2004.04.022. PMID 15242783. Ehrnsperger A, Rehli M, Thu-Hang P, Kreutz M 2005. Epigenetic regulation of the dendritic cell-marker gene ADAM19.. Biochem. Biophys. Res. Commun. 332 2: 456-64. doi:10.1016/j.bbrc.2005.04.149. PMID 15896713. Melenhorst WB, van den Heuvel MC, Stegeman CA, et al. 2006. Upregulation of ADAM19 in chronic allograft nephropathy.. Am. J. Transplant. 6 7: 1673-81. doi:10.1111/j.1600-6143.2006.01384.x. PMID 16827870. Tanabe C, Hotoda N, Sasagawa N, et al. 2007. ADAM19 is tightly associated with constitutive Alzheimer's disease APP alpha-secretase in A172 cells.. Biochem. Biophys. Res. Commun. 352 1: 111-7. doi:10.1016/j.bbrc.2006.10.181. PMID 17112471. This article on a gene on chromosome 5 is a stub. v d e Proteases: metalloendopeptidases EC 3.4.24 ADAM proteins Alpha secretases ADAM9 · ADAM10 · ADAM17 · ADAM19 · ADAM2 · ADAM7 · ADAM8 · ADAM11 · ADAM12 · ADAM15 · ADAM18 · ADAM22 · ADAM23 · ADAM28 · ADAM33 · ADAMTS1 · ADAMTS2 · ADAMTS3 · ADAMTS4 · ADAMTS5 · ADAMTS8 · ADAMTS9 · ADAMTS10 · ADAMTS12 · ADAMTS13 Matrix metalloproteinase Collagenase · Gelatinase Other Neprilysin · Procollagen peptidase · Thermolysin · Pregnancy-associated plasma protein A · Bone morphogenetic protein 1 · Insulysin · Lysostaphin · Insulin degrading enzyme Retrieved from http://en..org/wiki/ADAM19 Categories: Genes on chromosome 5 | Human proteins | Chromosome 5 gene stubsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 9 July 2008, at 18:18
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