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14-September-2008 18:02:48 - ADAM metallopeptidase domain 2 fertilin beta Identifiers Symbols ADAM2; CRYN1; CRYN2; FTNB; PH-30b; PH30 External IDs OMIM: 601533 MGI: 1340894 HomoloGene: 1127 Gene ontology Molecular function: metalloendopeptidase activity integrin binding protein binding Cellular component: integral to plasma membrane membrane Biological process: proteolysis cell adhesion fusion of sperm to egg plasma membrane RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 2515 11495 Ensembl ENSG00000104755 ENSMUSG00000022039 Uniprot Q99965 Q3TTP6 Refseq NM_001464 mRNA NP_001455 protein NM_009618 mRNA NP_033748 protein Location Chr 8: 39.72 - 39.81 Mb Chr 14: 64.98 - 65.03 Mb Pubmed search 1 2 ADAM metallopeptidase domain 2 fertilin beta, also known as ADAM2, is a human gene.1 This gene encodes a member of the ADAM a disintegrin and metalloprotease domain family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions.1 References ^ a b Entrez Gene: ADAM2 ADAM metallopeptidase domain 2 fertilin beta. Further reading Rual JF, Venkatesan K, Hao T, et al. 2005. Towards a proteome-scale map of the human protein-protein interaction network.. Nature 437 7062: 1173-8. doi:10.1038/nature04209. PMID 16189514. Gerhard DS, Wagner L, Feingold EA, et al. 2004. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection MGC.. Genome Res. 14 10B: 2121-7. doi:10.1101/gr.2596504. PMID 15489334. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Eto K, Huet C, Tarui T, et al. 2002. Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions.. J. Biol. Chem. 277 20: 17804-10. doi:10.1074/jbc.M200086200. PMID 11882657. Ikawa M, Nakanishi T, Yamada S, et al. 2002. Calmegin is required for fertilin alpha/beta heterodimerization and sperm fertility.. Dev. Biol. 240 1: 254-61. doi:10.1006/dbio.2001.0462. PMID 11784061. Cho C, Ge H, Branciforte D, et al. 2000. Analysis of mouse fertilin in wild-type and fertilin beta-/- sperm: evidence for C-terminal modification, alpha/beta dimerization, and lack of essential role of fertilin alpha in sperm-egg fusion.. Dev. Biol. 222 2: 289-95. doi:10.1006/dbio.2000.9703. PMID 10837118. Chen MS, Tung KS, Coonrod SA, et al. 1999. Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin alpha6beta1: implications for murine fertilization.. Proc. Natl. Acad. Sci. U.S.A. 96 21: 11830-5. PMID 10518536. Chen H, Sampson NS 1999. Mediation of sperm-egg fusion: evidence that mouse egg alpha6beta1 integrin is the receptor for sperm fertilinbeta.. Chem. Biol. 6 1: 1-10. doi:10.1016/S1074-55219980015-5. PMID 9889149. Burkin HR, Burkin DJ, Davey PM, et al. 1997. Mapping, sequence, and expression analysis of the human fertilin beta gene FTNB.. Genomics 40 1: 190-2. doi:10.1006/geno.1996.4531. PMID 9070941. Vidaeus CM, von Kapp-Herr C, Golden WL, et al. 1997. Human fertilin beta: identification, characterization, and chromosomal mapping of an ADAM gene family member.. Mol. Reprod. Dev. 46 3: 363-9. doi:10.1002/SICI1098-279519970346:3363::AID-MRD153.0.CO;2-#. PMID 9041139. Gupta SK, Alves K, Palladino LO, et al. 1996. Molecular cloning of the human fertilin beta subunit.. Biochem. Biophys. Res. Commun. 224 2: 318-26. doi:10.1006/bbrc.1996.1027. PMID 8702389. Dawson SJ, White LA 1992. Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin.. J. Infect. 24 3: 317-20. PMID 1602151. This article on a gene on chromosome 8 is a stub. v d e Proteases: metalloendopeptidases EC 3.4.24 ADAM proteins Alpha secretases ADAM9 · ADAM10 · ADAM17 · ADAM19 · ADAM2 · ADAM7 · ADAM8 · ADAM11 · ADAM12 · ADAM15 · ADAM18 · ADAM22 · ADAM23 · ADAM28 · ADAM33 · ADAMTS1 · ADAMTS2 · ADAMTS3 · ADAMTS4 · ADAMTS5 · ADAMTS8 · ADAMTS9 · ADAMTS10 · ADAMTS12 · ADAMTS13 Matrix metalloproteinase Collagenase · Gelatinase Other Neprilysin · Procollagen peptidase · Thermolysin · Pregnancy-associated plasma protein A · Bone morphogenetic protein 1 · Insulysin · Lysostaphin · Insulin degrading enzyme Retrieved from http://en..org/wiki/ADAM2 Categories: Genes on chromosome 8 | Human proteins | Chromosome 8 gene stubsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 10 July 2008, at 08:31
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