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14-September-2008 18:02:49 - ADAM9 ADAM metallopeptidase domain 9 meltrin gamma Identifiers Symbols ADAM9; MCMP; KIAA0021; MDC9; Mltng External IDs OMIM: 602713 MGI: 105376 HomoloGene: 20824 Gene ontology Molecular function: metalloendopeptidase activity integrin binding protein binding zinc ion binding SH3 domain binding protein kinase binding metal ion binding Cellular component: integral to plasma membrane membrane Biological process: proteolysis protein kinase cascade Orthologs Human Mouse Entrez 8754 11502 Ensembl ENSG00000168615 ENSMUSG00000031555 Uniprot Q13443 Q3UG15 Refseq NM_001005845 mRNA NP_001005845 protein NM_007404 mRNA NP_031430 protein Location Chr 8: 38.97 - 39.08 Mb Chr 8: 26.42 - 26.48 Mb Pubmed search 1 2 ADAM metallopeptidase domain 9 meltrin gamma, also known as ADAM9, is a human gene.1 This gene encodes a member of the ADAM a disintegrin and metalloprotease domain family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Two alternative splice variants have been identified, encoding distinct isoforms.1 References ^ a b Entrez Gene: ADAM9 ADAM metallopeptidase domain 9 meltrin gamma. Further reading Nomura N, Miyajima N, Sazuka T, et al. 1995. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes KIAA0001-KIAA0040 deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.. DNA Res. 1 1: 27-35. PMID 7584026. Nomura N, Miyajima N, Sazuka T, et al. 1995. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes KIAA0001-KIAA0040 deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 supplement.. DNA Res. 1 1: 47-56. PMID 7584028. Weskamp G, Krätzschmar J, Reid MS, Blobel CP 1996. MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains.. J. Cell Biol. 132 4: 717-26. PMID 8647900. McKie N, Dallas DJ, Edwards T, et al. 1996. Cloning of a novel membrane-linked metalloproteinase from human myeloma cells.. Biochem. J. 318 Pt 2: 459-62. PMID 8809033. McKie N, Edwards T, Dallas DJ, et al. 1997. Expression of members of a novel membrane linked metalloproteinase family ADAM in human articular chondrocytes.. Biochem. Biophys. Res. Commun. 230 2: 335-9. doi:10.1006/bbrc.1996.5957. PMID 9016778. Izumi Y, Hirata M, Hasuwa H, et al. 1999. A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.. EMBO J. 17 24: 7260-72. doi:10.1093/emboj/17.24.7260. PMID 9857183. Roghani M, Becherer JD, Moss ML, et al. 1999. Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity.. J. Biol. Chem. 274 6: 3531-40. PMID 9920899. Nelson KK, Schlöndorff J, Blobel CP 2000. Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase TACE with mitotic arrest deficient 2 MAD2, and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta.. Biochem. J. 343 Pt 3: 673-80. PMID 10527948. Howard L, Nelson KK, Maciewicz RA, Blobel CP 1999. Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1.. J. Biol. Chem. 274 44: 31693-9. PMID 10531379. Zhou M, Graham R, Russell G, Croucher PI 2001. MDC-9 ADAM-9/Meltrin gamma functions as an adhesion molecule by binding the alphavbeta5 integrin.. Biochem. Biophys. Res. Commun. 280 2: 574-80. doi:10.1006/bbrc.2000.4155. PMID 11162558. Namba K, Nishio M, Mori K, et al. 2002. Involvement of ADAM9 in multinucleated giant cell formation of blood monocytes.. Cell. Immunol. 213 2: 104-13. doi:10.1006/cimm.2001.1873. PMID 11831872. Eto K, Huet C, Tarui T, et al. 2002. Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions.. J. Biol. Chem. 277 20: 17804-10. doi:10.1074/jbc.M200086200. PMID 11882657. Lim JM, Lee JH, Wee WR, Joo CK 2002. Downregulated expression of ADAM9 in anterior polar cataracts.. Journal of cataract and refractive surgery 28 4: 697-702. PMID 11955914. Hotoda N, Koike H, Sasagawa N, Ishiura S 2002. A secreted form of human ADAM9 has an alpha-secretase activity for APP.. Biochem. Biophys. Res. Commun. 293 2: 800-5. doi:10.1016/S0006-291X0200302-9. PMID 12054541. Amour A, Knight CG, English WR, et al. 2002. The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs.. FEBS Lett. 524 1-3: 154-8. PMID 12135759. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Mohan S, Thompson GR, Amaar YG, et al. 2003. ADAM-9 is an insulin-like growth factor binding protein-5 protease produced and secreted by human osteoblasts.. Biochemistry 41 51: 15394-403. PMID 12484779. Asai M, Hattori C, Szabó B, et al. 2003. Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase.. Biochem. Biophys. Res. Commun. 301 1: 231-5. PMID 12535668. O'Shea C, McKie N, Buggy Y, et al. 2003. Expression of ADAM-9 mRNA and protein in human breast cancer.. Int. J. Cancer 105 6: 754-61. doi:10.1002/ijc.11161. PMID 12767059. Grützmann R, Lüttges J, Sipos B, et al. 2004. ADAM9 expression in pancreatic cancer is associated with tumour type and is a prognostic factor in ductal adenocarcinoma.. Br. J. Cancer 90 5: 1053-8. doi:10.1038/sj.bjc.6601645. PMID 14997207. This article on a gene on chromosome 8 is a stub. v d e Proteases: metalloendopeptidases EC 3.4.24 ADAM proteins Alpha secretases ADAM9 · ADAM10 · ADAM17 · ADAM19 · ADAM2 · ADAM7 · ADAM8 · ADAM11 · ADAM12 · ADAM15 · ADAM18 · ADAM22 · ADAM23 · ADAM28 · ADAM33 · ADAMTS1 · ADAMTS2 · ADAMTS3 · ADAMTS4 · ADAMTS5 · ADAMTS8 · ADAMTS9 · ADAMTS10 · ADAMTS12 · ADAMTS13 Matrix metalloproteinase Collagenase · Gelatinase Other Neprilysin · Procollagen peptidase · Thermolysin · Pregnancy-associated plasma protein A · Bone morphogenetic protein 1 · Insulysin · Lysostaphin · Insulin degrading enzyme Retrieved from http://en..org/wiki/ADAM9 Categories: Genes on chromosome 8 | Human proteins | Chromosome 8 gene stubsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 9 July 2008, at 10:59
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