Sierra Acai Company
Sierra Acai Company
Open 7 Days a Week
MonaVie Independent Distributor
Distributor Training
Shop Online
Enroll Now
Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
Friends
Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
14-September-2008 18:02:49 - ADAM metallopeptidase with thrombospondin type 1 motif, 1 Identifiers Symbols ADAMTS1; C3-C5; KIAA1346; METH1 External IDs OMIM: 605174 MGI: 109249 HomoloGene: 21381 Gene ontology Molecular function: metalloendopeptidase activity integrin binding protein binding heparin binding zinc ion binding metal ion binding Cellular component: basement membrane cytoplasmic vesicle Biological process: ovulation sensu Mammalia kidney development proteolysis integrin-mediated signaling pathway negative regulation of cell proliferation RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 9510 11504 Ensembl ENSG00000154734 ENSMUSG00000022893 Uniprot Q9UHI8 Q05DU9 Refseq NM_006988 mRNA NP_008919 protein NM_009621 mRNA NP_033751 protein Location Chr 21: 27.13 - 27.14 Mb Chr 16: 85.68 - 85.69 Mb Pubmed search 1 2 ADAM metallopeptidase with thrombospondin type 1 motif, 1, also known as METH-11 or ADAMTS1, is a human gene.2 This gene encodes a member of the ADAMTS a disintegrin and metalloproteinase with thrombospondin motif protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 TS motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function.2 References ^ Expression of METH-1 and METH-2 in Pancreatic Cancer -- Masui et ... ^ a b Entrez Gene: ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1. Further reading Tang BL, Hong W 1999. ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats.. FEBS Lett. 445 2-3: 223-5. PMID 10094461. Hirohata S 2002. ADAMTS family--new extracellular matrix degrading enzyme. Seikagaku 73 11: 1333-7. PMID 11831030. Kuno K, Kanada N, Nakashima E, et al. 1997. Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene.. J. Biol. Chem. 272 1: 556-62. PMID 8995297. Kuno K, Matsushima K 1998. ADAMTS-1 protein anchors at the extracellular matrix through the thrombospondin type I motifs and its spacing region.. J. Biol. Chem. 273 22: 13912-7. PMID 9593739. Kuno K, Terashima Y, Matsushima K 1999. ADAMTS-1 is an active metalloproteinase associated with the extracellular matrix.. J. Biol. Chem. 274 26: 18821-6. PMID 10373500. Vázquez F, Hastings G, Ortega MA, et al. 1999. METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity.. J. Biol. Chem. 274 33: 23349-57. PMID 10438512. Nagase T, Kikuno R, Ishikawa KI, et al. 2000. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.. DNA Res. 7 1: 65-73. PMID 10718198. Glienke J, Schmitt AO, Pilarsky C, et al. 2000. Differential gene expression by endothelial cells in distinct angiogenic states.. Eur. J. Biochem. 267 9: 2820-30. PMID 10785405. Shindo T, Kurihara H, Kuno K, et al. 2000. ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function.. J. Clin. Invest. 105 10: 1345-52. PMID 10811842. Hattori M, Fujiyama A, Taylor TD, et al. 2000. The DNA sequence of human chromosome 21.. Nature 405 6784: 311-9. doi:10.1038/35012518. PMID 10830953. Kuno K, Okada Y, Kawashima H, et al. 2000. ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan.. FEBS Lett. 478 3: 241-5. PMID 10930576. Sandy JD, Westling J, Kenagy RD, et al. 2001. Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4.. J. Biol. Chem. 276 16: 13372-8. doi:10.1074/jbc.M009737200. PMID 11278559. Wei P, Zhao YG, Zhuang L, et al. 2002. Protein engineering and properties of human metalloproteinase and thrombospondin 1.. Biochem. Biophys. Res. Commun. 293 1: 478-88. doi:10.1016/S0006-291X0200255-3. PMID 12054626. Rodríguez-Manzaneque JC, Westling J, Thai SN, et al. 2002. ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors.. Biochem. Biophys. Res. Commun. 293 1: 501-8. doi:10.1016/S0006-291X0200254-1. PMID 12054629. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Luque A, Carpizo DR, Iruela-Arispe ML 2003. ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165.. J. Biol. Chem. 278 26: 23656-65. doi:10.1074/jbc.M212964200. PMID 12716911. Russell DL, Doyle KM, Ochsner SA, et al. 2004. Processing and localization of ADAMTS-1 and proteolytic cleavage of versican during cumulus matrix expansion and ovulation.. J. Biol. Chem. 278 43: 42330-9. doi:10.1074/jbc.M300519200. PMID 12907688. Ota T, Suzuki Y, Nishikawa T, et al. 2004. Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat. Genet. 36 1: 40-5. doi:10.1038/ng1285. PMID 14702039. This article on a gene on chromosome 21 is a stub. v d e Proteases: metalloendopeptidases EC 3.4.24 ADAM proteins Alpha secretases ADAM9 · ADAM10 · ADAM17 · ADAM19 · ADAM2 · ADAM7 · ADAM8 · ADAM11 · ADAM12 · ADAM15 · ADAM18 · ADAM22 · ADAM23 · ADAM28 · ADAM33 · ADAMTS1 · ADAMTS2 · ADAMTS3 · ADAMTS4 · ADAMTS5 · ADAMTS8 · ADAMTS9 · ADAMTS10 · ADAMTS12 · ADAMTS13 Matrix metalloproteinase Collagenase · Gelatinase Other Neprilysin · Procollagen peptidase · Thermolysin · Pregnancy-associated plasma protein A · Bone morphogenetic protein 1 · Insulysin · Lysostaphin · Insulin degrading enzyme Retrieved from http://en..org/wiki/ADAMTS1 Categories: Genes on chromosome 21 | Human proteins | Chromosome 21 gene stubsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 9 July 2008, at 09:34
39 Reasons to Drink Acai Juice Every Day
What is MonaVie - Watch the 8-minute video
Discovering MonaVie Video
The Power of You Video
Effects of MonaVie Active on Antioxidant Capacity in Humans
Log into your Wholesale MonaVie Account
So many of us do not eat a balanced diet, get enough sleep, have too much stress, or are impacted with toxins and pollutants. Drinking 2 ounces of MonaVie twice a day will help your body detoxify as well as build your immune system. Its the smartest thing you can do for yourself, so start today. Buying MonaVie through our company guarantees you support 7 days a week and, if you would like to share MonaVie with your family and friends we will guide you from start to finish.
1. Click on Enroll Now (30 - 55% off retail price)
2. Pay $39 for your Wholesale ID number.
3. NO minimum order required.
4. MonaVie is delivered to your door in 3 to 5 days.