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14-September-2008 18:02:49 - ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 Identifiers Symbols ADAMTS9; FLJ42955; KIAA1312 External IDs OMIM: 605421 HomoloGene: 18821 Gene ontology Molecular function: metalloendopeptidase activity zinc ion binding metal ion binding Cellular component: proteinaceous extracellular matrix Biological process: proteolysis glycoprotein catabolic process multicellular organismal development RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 56999 n/a Ensembl ENSG00000163638 n/a Uniprot Q9P2N4 n/a Refseq NM_182920 mRNA NP_891550 protein n/a mRNA n/a protein Location Chr 3: 64.48 - 64.65 Mb n/a Pubmed search 1 n/a ADAM metallopeptidase with thrombospondin type 1 motif, 9, also known as ADAMTS9, is a human gene.1 This gene encodes a member of the ADAMTS a disintegrin and metalloproteinase with thrombospondin motifs protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 TS motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. Members of the ADAMTS family have been implicated in the cleavage of proteoglycans, the control of organ shape during development, and the inhibition of angiogenesis. This gene is localized to chromosome 3p14.3-p14.2, an area known to be lost in herary renal tumors.1 References ^ a b Entrez Gene: ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9. Further reading Tang BL 2001. ADAMTS: a novel family of extracellular matrix proteases.. Int. J. Biochem. Cell Biol. 33 1: 33-44. PMID 11167130. Nagase T, Kikuno R, Ishikawa KI, et al. 2000. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.. DNA Res. 7 1: 65-73. PMID 10718198. Clark ME, Kelner GS, Turbeville LA, et al. 2000. ADAMTS9, a novel member of the ADAM-TS/ metallospondin gene family.. Genomics 67 3: 343-50. doi:10.1006/geno.2000.6246. PMID 10936055. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Somerville RP, Longpre JM, Jungers KA, et al. 2003. Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1.. J. Biol. Chem. 278 11: 9503-13. doi:10.1074/jbc.M211009200. PMID 12514189. Ota T, Suzuki Y, Nishikawa T, et al. 2004. Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat. Genet. 36 1: 40-5. doi:10.1038/ng1285. PMID 14702039. Cross NA, Chandrasekharan S, Jokonya N, et al. 2005. The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation of versican.. Prostate 63 3: 269-75. doi:10.1002/pros.20182. PMID 15599946. Zeng W, Corcoran C, Collins-Racie LA, et al. 2006. Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and -18.. Biochim. Biophys. Acta 1760 3: 517-24. doi:10.1016/j.bbagen.2006.01.013. PMID 16507336. Koo BH, Longpré JM, Somerville RP, et al. 2006. Cell-surface processing of pro-ADAMTS9 by furin.. J. Biol. Chem. 281 18: 12485-94. doi:10.1074/jbc.M511083200. PMID 16537537. Lo PH, Leung AC, Kwok CY, et al. 2007. Identification of a tumor suppressive critical region mapping to 3p14.2 in esophageal squamous cell carcinoma and studies of a candidate tumor suppressor gene, ADAMTS9.. Oncogene 26 1: 148-57. doi:10.1038/sj.onc.1209767. PMID 16799631. This article on a gene on chromosome 3 is a stub. v d e Proteases: metalloendopeptidases EC 3.4.24 ADAM proteins Alpha secretases ADAM9 · ADAM10 · ADAM17 · ADAM19 · ADAM2 · ADAM7 · ADAM8 · ADAM11 · ADAM12 · ADAM15 · ADAM18 · ADAM22 · ADAM23 · ADAM28 · ADAM33 · ADAMTS1 · ADAMTS2 · ADAMTS3 · ADAMTS4 · ADAMTS5 · ADAMTS8 · ADAMTS9 · ADAMTS10 · ADAMTS12 · ADAMTS13 Matrix metalloproteinase Collagenase · Gelatinase Other Neprilysin · Procollagen peptidase · Thermolysin · Pregnancy-associated plasma protein A · Bone morphogenetic protein 1 · Insulysin · Lysostaphin · Insulin degrading enzyme Retrieved from http://en..org/wiki/ADAMTS9 Categories: Genes on chromosome 3 | Human proteins | Chromosome 3 gene stubsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 9 July 2008, at 03:19
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