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14-September-2008 18:02:49 - ADAM protein ADAM protein A Disintegrin And Metalloproteinase protein is a family of peptidase proteins1. ADAMs are also known as the Adamalysin family. ADAMs are classified as Sheddases because they cut off or shed extracellular portions of transmembrane proteins. For example, ADAM 10 can cut off part of the HER2 receptor, activating it2. Therapeutic ADAM inhibitors can potentiate anti-cancer therapycitation needed. It is categorized under EC 3.4.24.46. Types include: ADAMTS2 ADAMTS13 ADAMTS5 ADAM17 References ^ Wolfsberg TG, Straight PD, Gerena RL, et al 1995. ADAM, a widely distributed and developmentally regulated gene family encoding membrane proteins with a disintegrin and metalloprotease domain. Dev. Biol. 169 1: 378-383. doi:10.1006/dbio.1995.1152. PMID 7750654. ^ Liu, P.C.; et. al 2006. Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells.. Cancer Biology and Therapy 6: 657-664. External links MeSH ADAM+Proteins http://www.healthvalue.net/sheddase.html This hydrolase article is a stub. v d e Proteases: metalloendopeptidases EC 3.4.24 ADAM proteins Alpha secretases ADAM9 · ADAM10 · ADAM17 · ADAM19 · ADAM2 · ADAM7 · ADAM8 · ADAM11 · ADAM12 · ADAM15 · ADAM18 · ADAM22 · ADAM23 · ADAM28 · ADAM33 · ADAMTS1 · ADAMTS2 · ADAMTS3 · ADAMTS4 · ADAMTS5 · ADAMTS8 · ADAMTS9 · ADAMTS10 · ADAMTS12 · ADAMTS13 Matrix metalloproteinase Collagenase · Gelatinase Other Neprilysin · Procollagen peptidase · Thermolysin · Pregnancy-associated plasma protein A · Bone morphogenetic protein 1 · Insulysin · Lysostaphin · Insulin degrading enzyme v d e Protein: glycoproteins Activin - ADAM protein - Alpha 1-antichymotrypsin - Apolipoprotein H - CD70 - Asialoglycoprotein - Avidin - B-cell activating factor - 4-1BB ligand - Cholesterylester transfer protein - Clusterin - Colony-stimulating factor - Haemopexin - Inhibin - Lactoferrin - Membrane glycoproteins - Mucoprotein - Myelin protein zero - Osteonectin - Protein C - Protein S - Proteoglycan - Serum amyloid P component - Sialoglycoprotein CD43, Glycophorin, Glycophorin C - Thrombopoietin - Thyroglobulin - Thyroxine-binding proteins - Transcortin - Tumor necrosis factor-alpha - Uteroglobin - Vitronectin Retrieved from http://en..org/wiki/ADAM_protein Categories: Hydrolase stubsHidden categories: All articles with statements | Articles with statements since March 2007 Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Português This page was last modified on 17 June 2008, at 18:44
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