Sierra Acai Company
Sierra Acai Company
Open 7 Days a Week
MonaVie Independent Distributor
Distributor Training
Shop Online
Enroll Now
Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
Friends
Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
14-September-2008 18:02:41 - ADCYAP1R1 Adenylate cyclase activating polypeptide 1 pituitary receptor type I Identifiers Symbols ADCYAP1R1; PACAPR; PACAPRI External IDs OMIM: 102981 MGI: 108449 HomoloGene: 870 Gene ontology Molecular function: receptor activity G-protein coupled receptor activity vasoactive intestinal polypeptide receptor activity Cellular component: plasma membrane integral to plasma membrane membrane Biological process: G-protein coupled receptor protein signaling pathway multicellular organismal development spermatogenesis cell differentiation RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 117 11517 Ensembl ENSG00000078549 ENSMUSG00000029778 Uniprot P41586 Q8BLT3 Refseq NM_001118 mRNA NP_001109 protein NM_001025372 mRNA NP_001020543 protein Location Chr 7: 31.06 - 31.11 Mb Chr 6: 55.38 - 55.43 Mb Pubmed search 1 2 Adenylate cyclase activating polypeptide 1 pituitary receptor type I, also known as ADCYAP1R1 or pituitary adenylate cyclase-activating polypeptide receptor 1 PACAPR1, is a human gene. This receptor binds pituitary adenylate cyclase activating peptide.12 This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the G-protein coupled class B glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Alternative splicing of two exons of this gene generates four major splice variants, but their full-length nature has not been determined.3 References ^ Ogi K, Miyamoto Y, Masuda Y, Habata Y, Hosoya M, Ohtaki T, Masuo Y, Onda H, Fujino M 1993. Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor. Biochem. Biophys. Res. Commun. 196 3: 1511-21. doi:10.1006/bbrc.1993.2423. PMID 7902709. ^ Vaudry D, Gonzalez BJ, Basille M, Yon L, Fournier A, Vaudry H 2000. Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions. Pharmacol. Rev. 52 2: 269-324. PMID 10835102. ^ Entrez Gene: ADCYAP1R1 adenylate cyclase activating polypeptide 1 pituitary receptor type I. Further reading Stoffel M, Espinosa R, Trabb JB, et al. 1995. Human type I pituitary adenylate cyclase activating polypeptide receptor ADCYAP1R: localization to chromosome band 7p14 and integration into the cytogenetic, physical, and genetic map of chromosome 7.. Genomics 23 3: 697-9. doi:10.1006/geno.1994.1560. PMID 7851900. Ogi K, Miyamoto Y, Masuda Y, et al. 1994. Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor.. Biochem. Biophys. Res. Commun. 196 3: 1511-21. doi:10.1006/bbrc.1993.2423. PMID 7902709. Ohtaki T, Masuda Y, Ishibashi Y, et al. 1994. Purification and characterization of the receptor for pituitary adenylate cyclase-activating polypeptide.. J. Biol. Chem. 268 35: 26650-7. PMID 8253796. Pisegna JR, Wank SA 1996. Cloning and characterization of the signal transduction of four splice variants of the human pituitary adenylate cyclase activating polypeptide receptor. Evidence for dual coupling to adenylate cyclase and phospholipase C.. J. Biol. Chem. 271 29: 17267-74. PMID 8663363. Pantaloni C, Brabet P, Bilanges B, et al. 1996. Alternative splicing in the N-terminal extracellular domain of the pituitary adenylate cyclase-activating polypeptide PACAP receptor modulates receptor selectivity and relative potencies of PACAP-27 and PACAP-38 in phospholipase C activation.. J. Biol. Chem. 271 36: 22146-51. PMID 8703026. Solano RM, Carmena MJ, Carrero I, et al. 1996. Characterization of vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptors in human benign hyperplastic prostate.. Endocrinology 137 7: 2815-22. PMID 8770902. Wei Y, Mojsov S 1997. Tissue specific expression of different human receptor types for pituitary adenylate cyclase activating polypeptide and vasoactive intestinal polypeptide: implications for their role in human physiology.. J. Neuroendocrinol. 8 11: 811-7. PMID 8933357. Brabet P, Diriong S, Journot L, et al. 1997. Localization of the human pituitary adenylate cyclase-activating polypeptide receptor PACAP1-R gene to 7p15-p14 by fluorescence in situ hybridization.. Genomics 38 1: 100-2. doi:10.1006/geno.1996.0600. PMID 8954788. Yon L, Breault L, Contesse V, et al. 1998. Localization, characterization, and second messenger coupling of pituitary adenylate cyclase-activating polypeptide receptors in the fetal human adrenal gland during the second trimester of gestation.. J. Clin. Endocrinol. Metab. 83 4: 1299-305. PMID 9543159. Steinhoff M, McGregor GP, Radleff-Schlimme A, et al. 1999. Identification of pituitary adenylate cyclase activating polypeptide PACAP and PACAP type 1 receptor in human skin: expression of PACAP-38 is increased in patients with psoriasis.. Regul. Pept. 80 1-2: 49-55. PMID 10235634. Zeng N, Athmann C, Kang T, et al. 1999. PACAP type I receptor activation regulates ECL cells and gastric acid secretion.. J. Clin. Invest. 104 10: 1383-91. PMID 10562300. Dautzenberg FM, Mevenkamp G, Wille S, Hauger RL 2000. N-terminal splice variants of the type I PACAP receptor: isolation, characterization and ligand binding/selectivity determinants.. J. Neuroendocrinol. 11 12: 941-9. PMID 10583729. Scaldaferri ML, Modesti A, Palumbo C, et al. 2000. Pituitary adenylate cyclase-activating polypeptide PACAP and PACAP-receptor type 1 expression in rat and human placenta.. Endocrinology 141 3: 1158-67. PMID 10698193. Busto R, Prieto JC, Bodega G, et al. 2000. Immunohistochemical localization and distribution of VIP/PACAP receptors in human lung.. Peptides 21 2: 265-9. PMID 10764955. Knutsson M, Edvinsson L 2002. Distribution of mRNA for VIP and PACAP receptors in human cerebral arteries and cranial ganglia.. Neuroreport 13 4: 507-9. PMID 11930171. Miampamba M, Germano PM, Arli S, et al. 2002. Expression of pituitary adenylate cyclase-activating polypeptide and PACAP type 1 receptor in the rat gastric and colonic myenteric neurons.. Regul. Pept. 105 3: 145-54. PMID 11959368. Le SV, Yamaguchi DJ, McArdle CA, et al. 2003. PAC1 and PACAP expression, signaling, and effect on the growth of HCT8, human colonic tumor cells.. Regul. Pept. 109 1-3: 115-25. PMID 12409223. Ronaldson E, Robertson DN, Johnson MS, et al. 2003. Specific interaction between the hop1 intracellular loop 3 domain of the human PAC1 receptor and ARF.. Regul. Pept. 109 1-3: 193-8. PMID 12409233. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Isobe K, Tatsuno I, Yashiro T, et al. 2003. Expression of mRNA for PACAP and its receptors in intra- and extra-adrenal human pheochromocytomas and their relationship to catecholamine synthesis.. Regul. Pept. 110 3: 213-7. PMID 12573802. This article incorporates text from the United States National Library of Medicine, which is in the public domain. This membrane protein-related article is a stub. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/ADCYAP1R1 Categories: Genes on chromosome 7 | Human proteins | Membrane protein stubsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 10:15
39 Reasons to Drink Acai Juice Every Day
What is MonaVie - Watch the 8-minute video
Discovering MonaVie Video
The Power of You Video
Effects of MonaVie Active on Antioxidant Capacity in Humans
Log into your Wholesale MonaVie Account
So many of us do not eat a balanced diet, get enough sleep, have too much stress, or are impacted with toxins and pollutants. Drinking 2 ounces of MonaVie twice a day will help your body detoxify as well as build your immune system. Its the smartest thing you can do for yourself, so start today. Buying MonaVie through our company guarantees you support 7 days a week and, if you would like to share MonaVie with your family and friends we will guide you from start to finish.
1. Click on Enroll Now (30 - 55% off retail price)
2. Pay $39 for your Wholesale ID number.
3. NO minimum order required.
4. MonaVie is delivered to your door in 3 to 5 days.