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14-September-2008 18:02:41 - b receptor The correct title of this article is Adenosine A2b receptor. It appears incorrectly here because of technical restrictions. Adenosine A2b receptor Identifiers Symbols ADORA2B; ADORA2 External IDs OMIM: 600446 MGI: 99403 HomoloGene: 20167 Gene ontology Molecular function: rhodopsin-like receptor activity A2B adenosine receptor activity, G-protein coupled receptor activity Cellular component: integral to plasma membrane membrane Biological process: activation of MAPK activity cellular defense response signal transduction G-protein coupled receptor protein signaling pathway adenylate cyclase activation JNK cascade excretion RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 136 11541 Ensembl ENSG00000170425 n/a Uniprot P29275 n/a Refseq NM_000676 mRNA NP_000667 protein XM_906642 mRNA XP_911735 protein Location Chr 17: 15.79 - 15.82 Mb n/a Pubmed search 1 2 The adenosine A2b receptor, also known as ADORA2B, is an adenosine receptor, and also denotes the human gene incoding it.1 Contents 1 Mechanism 2 Gene 3 References 4 Further reading Mechanism This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. Gene The gene is located near the Smith-Magenis syndrome region on chromosome 17.1 References ^ a b Entrez Gene: ADORA2B adenosine A2b receptor. Further reading Stiles GL 1992. Adenosine receptors.. J. Biol. Chem. 267 10: 6451-4. PMID 1551861. Pierce KD, Furlong TJ, Selbie LA, Shine J 1992. Molecular cloning and expression of an adenosine A2b receptor from human brain.. Biochem. Biophys. Res. Commun. 187 1: 86-93. PMID 1325798. Jacobson MA, Johnson RG, Luneau CJ, Salvatore CA 1995. Cloning and chromosomal localization of the human A2b adenosine receptor gene ADORA2B and its pseudogene.. Genomics 27 2: 374-6. doi:10.1006/geno.1995.1061. PMID 7558011. Townsend-Nicholson A, Baker E, Sutherland GR, Schofield PR 1995. Localization of the adenosine A2b receptor subtype gene ADORA2B to chromosome 17p11.2-p12 by FISH and PCR screening of somatic cell hybrids.. Genomics 25 2: 605-7. PMID 7790006. Strohmeier GR, Reppert SM, Lencer WI, Madara JL 1995. The A2b adenosine receptor mediates cAMP responses to adenosine receptor agonists in human intestinal epithelia.. J. Biol. Chem. 270 5: 2387-94. PMID 7836474. Feoktistov I, Murray JJ, Biaggioni I 1994. Positive modulation of intracellular Ca2+ levels by adenosine A2b receptors, prostacyclin, and prostaglandin E1 via a cholera toxin-sensitive mechanism in human erythroleukemia cells.. Mol. Pharmacol. 45 6: 1160-7. PMID 8022409. Mirabet M, Herrera C, Cordero OJ, et al. 1999. Expression of A2B adenosine receptors in human lymphocytes: their role in T cell activation.. J. Cell. Sci. 112 Pt 4: 491-502. PMID 9914161. Feoktistov I, Goldstein AE, Biaggioni I 1999. Role of p38 mitogen-activated protein kinase and extracellular signal-regulated protein kinase kinase in adenosine A2B receptor-mediated interleukin-8 production in human mast cells.. Mol. Pharmacol. 55 4: 726-34. PMID 10101031. Corset V, Nguyen-Ba-Charvet KT, Forcet C, et al. 2000. Netrin-1-mediated axon outgrowth and cAMP production requires interaction with adenosine A2b receptor.. Nature 407 6805: 747-50. doi:10.1038/35037600. PMID 11048721. Herrera C, Casadó V, Ciruela F, et al. 2001. Adenosine A2B receptors behave as an alternative anchoring protein for cell surface adenosine deaminase in lymphocytes and cultured cells.. Mol. Pharmacol. 59 1: 127-34. PMID 11125033. Christofi FL, Zhang H, Yu JG, et al. 2001. Differential gene expression of adenosine A1, A2a, A2b, and A3 receptors in the human enteric nervous system.. J. Comp. Neurol. 439 1: 46-64. doi:10.1002/cne.1334. PMID 11579381. Hayallah AM, Sandoval-Ramírez J, Reith U, et al. 2002. 1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists.. J. Med. Chem. 45 7: 1500-10. PMID 11906291. Sitaraman SV, Wang L, Wong M, et al. 2002. The adenosine 2b receptor is recruited to the plasma membrane and associates with E3KARP and Ezrin upon agonist stimulation.. J. Biol. Chem. 277 36: 33188-95. doi:10.1074/jbc.M202522200. PMID 12080047. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Feoktistov I, Ryzhov S, Goldstein AE, Biaggioni I 2003. Mast cell-mediated stimulation of angiogenesis: cooperative interaction between A2B and A3 adenosine receptors.. Circ. Res. 92 5: 485-92. doi:10.1161/01.RES.0000061572.10929.2D. PMID 12600879. Eltzschig HK, Ibla JC, Furuta GT, et al. 2003. Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptors.. J. Exp. Med. 198 5: 783-96. doi:10.1084/jem.20030891. PMID 12939345. Ryzhov S, Goldstein AE, Matafonov A, et al. 2004. Adenosine-activated mast cells induce IgE synthesis by B lymphocytes: an A2B-mediated process involving Th2 cytokines IL-4 and IL-13 with implications for asthma.. J. Immunol. 172 12: 7726-33. PMID 15187156. Gerhard DS, Wagner L, Feingold EA, et al. 2004. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection MGC.. Genome Res. 14 10B: 2121-7. doi:10.1101/gr.2596504. PMID 15489334. Kolachala V, Asamoah V, Wang L, et al. 2005. Interferon-gamma down-regulates adenosine 2b receptor-mediated signaling and short circuit current in the intestinal epithelia by inhibiting the expression of adenylate cyclase.. J. Biol. Chem. 280 6: 4048-57. doi:10.1074/jbc.M409577200. PMID 15550390. This transmembrane receptor-related article is a stub. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Adenosine_A2b_receptor Categories: Genes on chromosome 17 | Human proteins | Transmembrane receptor stubs | Adrenergic receptors | Signal transductionHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 11:35
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