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14-September-2008 18:02:41 - A3 receptor The correct title of this article is Adenosine A3 receptor. It appears incorrectly here because of technical restrictions. Adenosine A3 receptor Identifiers Symbols ADORA3; A3AR; AD026; RP11-552M11.7; bA552M11.5 External IDs OMIM: 600445 MGI: 104847 HomoloGene: 550 Gene ontology Molecular function: rhodopsin-like receptor activity A3 adenosine receptor activity, G-protein coupled receptor activity Cellular component: integral to plasma membrane membrane Biological process: inflammatory response signal transduction G-protein coupled receptor protein signaling pathway adenylate cyclase activation regulation of heart contraction RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 140 11542 Ensembl ENSG00000121933 ENSMUSG00000000562 Uniprot P33765 Q3U4C5 Refseq NM_000677 mRNA NP_000668 protein NM_009631 mRNA NP_033761 protein Location Chr 1: 111.83 - 111.91 Mb Chr 3: 106.03 - 106.04 Mb Pubmed search 1 2 The adenosine A3 receptor, also known as ADORA3, is an adenosine receptor, but also denotes the human gene encoding it. Contents 1 Function 2 Gene 3 Therapeutic implications 4 References 5 Further reading Function Adenosine A3 receptors are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. It mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Gene Multiple transcript variants encoding different isoforms have been found for this gene.1 Therapeutic implications An adenosine A3 receptor agonist CF-101 is in clinical trials for the treatment of rheumatoid arthritis.2 In a mouse model of infarction the A3 selective agonist CP-532,903 protected against myocardial ischemia and reperfusion injury. 3 References ^ Entrez Gene: ADORA3 adenosine A3 receptor. ^ Silverman MH, Strand V, Markovits D, et al 2007. Clinical Evidence for Utilization of the A3 Adenosine Receptor as a Target to Treat Rheumatoid Arthritis: Data from a Phase II Clinical Trial. J Rheumatol. PMID 18050382. ^ Wan TC, Ge ZD, Tampo A, et al 2007. The A3 adenosine receptor agonist CP-532,903 protects against myocardial ischemia/reperfusion injury via the sarcolemmal ATP sensitive potassium channel. J Pharmacol Exp Ther. doi:10.1124/jpet.107.127480. PMID 17906066. Further reading Klotz KN 2001. Adenosine receptors and their ligands.. Naunyn Schmiedebergs Arch. Pharmacol. 362 4-5: 382-91. PMID 11111832. Monitto CL, Levitt RC, DiSilvestre D, Holroyd KJ 1995. Localization of the A3 adenosine receptor gene ADORA3 to human chromosome 1p.. Genomics 26 3: 637-8. PMID 7607699. Salvatore CA, Jacobson MA, Taylor HE, et al. 1993. Molecular cloning and characterization of the human A3 adenosine receptor.. Proc. Natl. Acad. Sci. U.S.A. 90 21: 10365-9. PMID 8234299. Sajjadi FG, Firestein GS 1993. cDNA cloning and sequence analysis of the human A3 adenosine receptor.. Biochim. Biophys. Acta 1179 1: 105-7. PMID 8399349. Murrison EM, Goodson SJ, Edbrooke MR, Harris CA 1996. Cloning and characterisation of the human adenosine A3 receptor gene.. FEBS Lett. 384 3: 243-6. PMID 8617363. Bonaldo MF, Lennon G, Soares MB 1997. Normalization and subtraction: two approaches to facilitate gene discovery.. Genome Res. 6 9: 791-806. PMID 8889548. Bouma MG, Jeunhomme TM, Boyle DL, et al. 1997. Adenosine inhibits neutrophil degranulation in activated human whole blood: involvement of adenosine A2 and A3 receptors.. J. Immunol. 158 11: 5400-8. PMID 9164961. Atkinson MR, Townsend-Nicholson A, Nicholl JK, et al. 1998. Cloning, characterisation and chromosomal assignment of the human adenosine A3 receptor ADORA3 gene.. Neurosci. Res. 29 1: 73-9. PMID 9293494. Palmer TM, Harris CA, Coote J, Stiles GL 1997. Induction of multiple effects on adenylyl cyclase regulation by chronic activation of the human A3 adenosine receptor.. Mol. Pharmacol. 52 4: 632-40. PMID 9380026. Liang BT, Jacobson KA 1998. A physiological role of the adenosine A3 receptor: sustained cardioprotection.. Proc. Natl. Acad. Sci. U.S.A. 95 12: 6995-9. PMID 9618527. Dougherty C, Barucha J, Schofield PR, et al. 1999. Cardiac myocytes rendered ischemia resistant by expressing the human adenosine A1 or A3 receptor.. FASEB J. 12 15: 1785-92. PMID 9837869. Murphy WJ, Eizirik E, Johnson WE, et al. 2001. Molecular phylogenetics and the origins of placental mammals.. Nature 409 6820: 614-8. doi:10.1038/35054550. PMID 11214319. Gao ZG, Chen A, Barak D, et al. 2002. Identification by site-directed mutagenesis of residues involved in ligand recognition and activation of the human A3 adenosine receptor.. J. Biol. Chem. 277 21: 19056-63. doi:10.1074/jbc.M110960200. PMID 11891221. Broussas M, Cornillet-Lefèbvre P, Potron G, Nguyên P 2003. Adenosine inhibits tissue factor expression by LPS-stimulated human monocytes: involvement of the A3 adenosine receptor.. Thromb. Haemost. 88 1: 123-30. PMID 12152652. Merighi S, Mirandola P, Milani D, et al. 2002. Adenosine receptors as mediators of both cell proliferation and cell death of cultured human melanoma cells.. J. Invest. Dermatol. 119 4: 923-33. doi:10.1046/j.1523-1747.2002.00111.x. PMID 12406340. Trincavelli ML, Tuscano D, Marroni M, et al. 2002. A3 adenosine receptors in human astrocytoma cells: agonist-mediated desensitization, internalization, and down-regulation.. Mol. Pharmacol. 62 6: 1373-84. PMID 12435805. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Feoktistov I, Ryzhov S, Goldstein AE, Biaggioni I 2003. Mast cell-mediated stimulation of angiogenesis: cooperative interaction between A2B and A3 adenosine receptors.. Circ. Res. 92 5: 485-92. doi:10.1161/01.RES.0000061572.10929.2D. PMID 12600879. Gao ZG, Kim SK, Gross AS, et al. 2003. Identification of essential residues involved in the allosteric modulation of the human A3 adenosine receptor.. Mol. Pharmacol. 63 5: 1021-31. PMID 12695530. This transmembrane receptor-related article is a stub. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Adenosine_A3_receptor Categories: Genes on chromosome 1 | Human proteins | Transmembrane receptor stubs | Adrenergic receptors | Signal transductionHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 10:06
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