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14-September-2008 18:02:45 - Adipose tissue Adipose tissue is one of the main types of connective tissue. Adipose tissue is one of the main types of connective tissue. Adipose redirects here. For the Doctor Who monster, see Partners in Crime. In histology, adipose tissue or fat is loose connective tissue composed of adipocytes. Adipose tissue is derived from lipoblasts. Its main role is to store energy in the form of fat, although it also cushions and insulates the body. Obesity or being overweight in humans and most animals does not depend on body weight but on the amount of body fat-specifically, adipose tissue. Two types of adipose tissue exist: white adipose tissue WAT and brown adipose tissue BAT. Adipose tissue also serves as an important endocrine organ1 by producing hormones such as leptin, resistin and the cytokine TNFα. The formation of adipose tissue appears to be controlled by the adipose gene. Contents 1 Anatomical features 1.1 Mice 1.2 Obesity 2 Physiology 2.1 Brown fat 2.2 Genetics 2.3 Physical properties 3 Cultural and social role 4 Additional images 5 References 6 See also Anatomical features In humans, adipose tissue is located beneath the skin subcutaneous fat, around internal organs visceral fat, and in the bone marrow yellow bone marrow. Adipose tissue is found in specific locations which are referred to as 'adipose depots.' Adipose tissue contains several cell types, with the highest percentage of cells being adipocytes, which contain fat droplets. Other cell types include fibroblasts, macrophages and endothelial cells. Adipose tissue contains many small blood vessels. In the integumentary system, which includes the skin, it accumulates in the deepest level, the subcutaneous layer, providing insulation from heat and cold. Around organs, it provides protective padding. However, its main function is to be a reserve of lipids, which can be burned to meet the energy needs of the body. Adipose depots in different parts of the body have different biochemical profiles. Mice In mice, there are eight major adipose depots, four of which are within the abdominal cavity: the paired gonadal depots are attached to the uterus and ovaries in females and the epididymis and testes in males, the paired retroperitoneal depots are found along the dorsal wall of the abdomen, surrounding the kidney, and when massive extend into the pelvis. The mesenteric depot forms a glue-like web that supports the intestines, and the omental depot, which originates near the stomach and spleen and when massive extends into the ventral abdomen. Both the mesenteric and omental depots incorporate much lymphoid tissue as lymph nodes and milky spots respectively. The two superficial depots are the paired inguinal depots, which are found anterior to the upper segment of the hind limbs underneath the skin and the subscapular depots, paired medial mixtures of brown adipose tissue adjacent to regions of white adipose tissue, which are found under the skin between the dorsal crests of the scapulae. The layer of brown adipose tissue in this depot is often covered by a frosting of white adipose tissue, sometimes these two types of fat brown and white are hard to distinguish. The inguinal depots enclose the inguinal group of lymph nodes. Minor depots include the pericardial which surrounds the heart, and the paired popliteal depots, between the major muscles behind the knees, each containing one large lymph node2. Of all the depots in the mouse, the gonadal depots are the largest and the most easily dissected3, comprising about 30% of dissectible fat4. Obesity An obese human male. An obese human male. In a severely obese person, excess adipose tissue hanging downward from the abdomen is referred to as a panniculus or pannus. A panniculus complicates surgery of the morbidly obese. The panniculus may remain as a literal apron of skin if a severely obese person quickly loses large amounts of fat a common result of gastric bypass surgery. This condition cannot be effectively corrected through diet and exercise alone, as the panniculus consists of adipocytes and other supporting cell types shrunken to their minimum volume and diameter. Reconstructive surgery is one method of treatment. Physiology July 2007 Free fatty acid is liberated from lipoproteins by lipoprotein lipase LPL and enters the adipocyte, where it is reassembled into triglycerides by esterifying it onto glycerol. Human fat tissue contains about 87% lipids. In humans, lipolysis is controlled though the balanced control of lipolytic B-adrenergic receptors and a2A-andronergic receptor mediated antilipolysis. Fat is not laid down when there is a surplus available and stored passively until it is needed; rather it is constantly being stored in and released from each cell. Fat cells have an important physiological role in maintaining triglyceride and free fatty acid levels, as well as determining insulin resistance. Abdominal fat has a different metabolic profile-being more prone to induce insulin resistance. This explains to a large degree why central obesity is a marker of impaired glucose tolerance and is an independent risk factor for cardiovascular disease even in the absence of diabetes mellitus and hypertension.citation needed Recent advances in biotechnology have allowed for the harvesting of adult stem cells from adipose tissue, allowing stimulation of tissue regrowth using a patient's own cells. The use of a patient's own cells reduces the chance of tissue rejection and avoids the ethical issues associated with the use of human embryonic stem cells. Adipose tissue is the greatest peripheral source of aromatase in both males and females contributing to the production of estradiol. Adipose derived hormones include: Adiponectin Resistin Angiotensin Plasminogen activator inhibitor-1 PAI-1 TNFα IL-6 Leptin Estradiol E2 Adipose tissues also secrete a type of cytokines cell-to-cell signalling proteins called adipokines adipocytokines which play a role in obesity-associated complications. Brown fat A specialised form of adipose tissue in human infants, most rodents and small mammals and some hibernating animals, is brown fat or brown adipose tissue. It is located mainly around the neck and large blood vessels of the thorax. This specialised tissue can generate heat by uncoupling the respiratory chain of oxidative phosphorylation within mitochondria. The process of uncoupling means that when protons transit down the electrochemical gradient across the inner mitochondrial membrane the energy from this process is released as heat rather than being used to generate ATP. This thermogenic process may be vital in neonates exposed to the cold, who then require this thermogenesis to keep warm as they are unable to shiver, or take other actions to keep themselves warm.5 Attempts to stimulate this process pharmacologically have so far been unsuccessful, but might in the future be a target of weight loss therapy. Genetics In 2007, researchers isolated the adipose gene, which ap-par-ently serves to keep animals lean dur-ing times of plen-ty. Increased adipose gene activity was associated with slimmer individuals.6 Physical properties Adipose tissue has a density of ~0.9g/ml 7. Thus, a person with much adipose tissue will float easier than a person with a lot of muscular tissue, since muscular tissue has a density of 1.06 g/ml7. Cultural and social role Excess adipose tissue on a human male. Excess adipose tissue on a human male. Excess adipose tissue on a human can lead to medical problems; however, a round or large figure does not of itself imply a medical problem, and is sometimes not primarily caused by adipose tissue. For a discussion of the aesthetic and medical significance of body shape, see dieting and obesity. Additional images diagrammatic sectional view of the skin magnified. Yellow adipose tissue in paraffin section References ^ Kershaw EE, Flier JS 2004. Adipose tissue as an endocrine organ. J. Clin. Endocrinol. Metab. 89 6: 2548-56. doi:10.1210/jc.2004-0395. PMID 15181022. ^ Pond, Caroline M. 1998. The Fats of Life. Cambridge University Press. ISBN 0521635772. ^ Cinti, S July 2005. The adipose organ. Prostaglandins, leukotrienes, and essential fatty acids 73 0952-3278: 9-15. Elsevier Science. doi:10.1016/j.plefa.2005.04.010. PMID 15936182. ^ Bachmanov, Alexander; D. R. Reed, M. G. Tordoff, R. A. Price March 2001. Nutrient preference and diet-induced adiposity in C57BL/6ByJ and 129P3/J mice. Physiology Behavior 72 0031-9384: 603-613. doi:10.1016/S0031-93840100412-7. PMID 11282146. ^ Himms-Hagen, J. August 1990 Brown adipose tissue thermogenesis: interdisciplinary studies The FASEB Journal Federation of American Societies for Experimental Biology 411: pp. 2890-2898 ^ Suh, Jae Myoung et al. September 2007 Adipose Is a Conserved Dosage-Sensitive Antiobesity Gene Cell Me-tab-o-lism 63: pp. 195-207 ^ a b Google Answers: Muscle Density vs. Fat Density Bachmanov AA, Reed DR, Tordoff MG, Price RA, Beauchamp GK 2001 Nutrient preference and diet-induced adiposity in C57BL/6ByJ and 129P3/J mice. Physiology and Behavior 72, 603-613 Cinti S 1999 The adipose organ. rice Kurtis, Milano Pond CM 1998 The fats of life. Cambridge University Press, Cambridge See also Apelin Bioelectrical impedance analysis: a method to measure body fat percentage. Body fat meter Body fat percentage Cellulite Obesity Steatosis Also called fatty change, fatty degeneration or adipose degeneration. Stem Cells Subcutaneous fat Visceral fat v d e Human anatomy, endocrine system: endocrine glands Hypothalamic/ pituitary axes Thyroid axis Thyroid gland Parafollicular cell, Thyroid epithelial cell, Thyroid isthmus, Lobes of thyroid gland, Pyramid of thyroid Parathyroid gland Oxyphil cell, Chief cell Adrenal axis Adrenal gland Gonadal axis Testes - Ovaries - Corpus luteum Pineal gland Pinealocyte Islets of pancreas Alpha cell - Beta cell - Delta cell - PP cell - Epsilon cell v d e Histology: connective tissue Classification proper Loose/areolar, Dense, Adipose Brown and White, Reticular embryonic Mucous, Mesenchymal specialized Cartilage, Bone, Blood Fibrous connective tissue Extracellular matrix ground substance Tissue fluid fibers Collagen, Reticular fiber, Elastic fibers Cells resident Fibroblast, Adipocyte, Chondroblast, Osteoblast Wandering cell see also soft tissue Retrieved from http://en..org/wiki/Adipose_tissue Categories: Tissues | ObesityHidden categories: Articles needing additional references from July 2007 | All articles with statements | Articles with statements since April 2008 Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Català Česky Dansk Deutsch Ελληνικά Español Français Galego Italiano Lietuvių Nederlands 日本語 ‪Norsk bokmÃ¥l‬ Polski Português РуÑ?Ñ?кий Suomi Svenska Türkçe This page was last modified on 12 September 2008, at 15:45
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