Sierra Acai Company
Sierra Acai Company
Open 7 Days a Week
MonaVie Independent Distributor
Distributor Training
Shop Online
Enroll Now
Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
Friends
Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
14-September-2008 18:02:41 - Adrenomedullin receptor Adrenomedullin receptor Identifiers Symbols ADMR; 7TMR; AMR; MGC34399; gamrh; hrhAMR External IDs OMIM: 605307 MGI: 109545 HomoloGene: 5255 Gene ontology Molecular function: rhodopsin-like receptor activity Cellular component: membrane integral to membrane Biological process: G-protein coupled receptor protein signaling pathway RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 11318 11536 Ensembl ENSG00000166856 n/a Uniprot O15218 n/a Refseq NM_007264 mRNA NP_009195 protein NM_007412 mRNA NP_031438 protein Location Chr 12: 55.67 - 55.68 Mb n/a Pubmed search 1 2 Adrenomedullin receptor is a receptor. Studies of the rat counterpart suggest that the encoded protein may function as a receptor for adrenomedullin.1 adrenomedullin. It is encoded by the human gene ADMR.1 Contents 1 Structure 2 Mechanism 3 References 4 Further reading Structure The structure of the adrenomedullin receptor is a calcitonin receptor-like receptor CL linked to the second or third of three single transmembrane domain receptor activity-modifying proteins RAMPs, i.e. RAMP2 or RAMP3, which are essential for functional activity. It is worth noting that unlike the classical one ligand-one receptor notion of receptor signalling, the interaction of both CL and RAMP at the membrane, is required for AM to mediate its action. Mechanism The outcome of AM stimulatation of its receptor is activation of the G protein Gs2, resulting in cellular production of both cyclic AMP cAMP. The activated adrenomedullin receptor also produces nitric oxide production. Some may find the production of these inside the cell to be at odds, since often they have opposing effects, but as yet, the timing of these effects remains to be studied. References ^ a b Entrez Gene: ADMR adrenomedullin receptor. ^ senselab Further reading Lah JJ, Frishman WH 2002. Adrenomedullin: a vasoactive and natriuretic peptide with therapeutic potential.. Heart disease Hagerstown, Md. 2 3: 259-65. PMID 11728267. Mukoyama M, Sugawara A, Nagae T, et al. 2002. Role of adrenomedullin and its receptor system in renal pathophysiology.. Peptides 22 11: 1925-31. PMID 11754983. Fowler DE, Wang P 2002. The cardiovascular response in sepsis: proposed mechanisms of the beneficial effect of adrenomedullin and its binding protein review.. Int. J. Mol. Med. 9 5: 443-9. PMID 11956648. Kato J, Kitamura K, Kangawa K, Eto T 1995. Receptors for adrenomedullin in human vascular endothelial cells.. Eur. J. Pharmacol. 289 2: 383-5. PMID 7621913. Martínez A, Miller MJ, Catt KJ, Cuttitta F 1997. Adrenomedullin receptor expression in human lung and in pulmonary tumors.. J. Histochem. Cytochem. 45 2: 159-64. PMID 9016306. Hänze J, Dittrich K, Dötsch J, Rascher W 1997. Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system.. Biochem. Biophys. Res. Commun. 240 1: 183-8. doi:10.1006/bbrc.1997.7631. PMID 9367907. Martínez A, Elsasser TH, Muro-Cacho C, et al. 1997. Expression of adrenomedullin and its receptor in normal and malignant human skin: a potential pluripotent role in the integument.. Endocrinology 138 12: 5597-604. PMID 9389548. Kennedy SP, Sun D, Oleynek JJ, et al. 1998. Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response.. Biochem. Biophys. Res. Commun. 244 3: 832-7. doi:10.1006/bbrc.1998.8349. PMID 9535752. Jiménez N, Calvo A, Martínez A, et al. 1999. Expression of adrenomedullin and proadrenomedullin N-terminal 20 peptide in human and rat prostate.. J. Histochem. Cytochem. 47 9: 1167-78. PMID 10449538. Kuwasako K, Kitamura K, Ito K, et al. 2002. The seven amino acids of human RAMP2 86 and RAMP3 59 are critical for agonist binding to human adrenomedullin receptors.. J. Biol. Chem. 276 52: 49459-65. doi:10.1074/jbc.M108369200. PMID 11591721. Forneris M, Gottardo L, Albertin G, et al. 2002. Expression and function of adrenomedullin and its receptors in Conn's adenoma cells.. Int. J. Mol. Med. 8 6: 675-9. PMID 11712085. Hänze J, Groneberg DA, Rose F, et al. 2002. Genomic organization and regulation of a human 7-helix transmembrane receptor which is expressed in pulmonary epithelial cells and induced in hypoxia.. Biochem. Biophys. Res. Commun. 291 5: 1160-5. doi:10.1006/bbrc.2002.6595. PMID 11883938. Dumont CE, Muff R, Flühmann B, et al. 2003. Paracrine/autocrine function of adrenomedullin in peripheral nerves of rats.. Brain Res. 955 1-2: 64-71. PMID 12419522. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Chosa E, Hamada H, Kitamura K, et al. 2003. Expression of adrenomedullin and its receptor by chondrocyte phenotype cells.. Biochem. Biophys. Res. Commun. 303 1: 379-86. PMID 12646214. Xu P, Dai AG, Zhou HD, et al. 2004. Study of the expression and role of adrenomedullin and adrenomedullin receptor in patients with chronic obstructive pulmonary disease. Zhonghua Jie He He Hu Xi Za Zhi 26 12: 765-8. PMID 14720432. Gerhard DS, Wagner L, Feingold EA, et al. 2004. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection MGC.. Genome Res. 14 10B: 2121-7. doi:10.1101/gr.2596504. PMID 15489334. This transmembrane receptor-related article is a stub. This article incorporates text from the United States National Library of Medicine, which is in the public domain. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Adrenomedullin_receptor Categories: Genes on chromosome 12 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 13
39 Reasons to Drink Acai Juice Every Day
What is MonaVie - Watch the 8-minute video
Discovering MonaVie Video
The Power of You Video
Effects of MonaVie Active on Antioxidant Capacity in Humans
Log into your Wholesale MonaVie Account
So many of us do not eat a balanced diet, get enough sleep, have too much stress, or are impacted with toxins and pollutants. Drinking 2 ounces of MonaVie twice a day will help your body detoxify as well as build your immune system. Its the smartest thing you can do for yourself, so start today. Buying MonaVie through our company guarantees you support 7 days a week and, if you would like to share MonaVie with your family and friends we will guide you from start to finish.
1. Click on Enroll Now (30 - 55% off retail price)
2. Pay $39 for your Wholesale ID number.
3. NO minimum order required.
4. MonaVie is delivered to your door in 3 to 5 days.