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14-September-2008 18:02:41 - D adrenergic receptor Adrenergic, alpha-1D-, receptor Identifiers Symbols ADRA1D; ADRA1; ADRA1A; ADRA1R; ALPHA1; DAR; dJ779E11.2 External IDs OMIM: 104219 MGI: 106673 HomoloGene: 551 Gene ontology Molecular function: rhodopsin-like receptor activity receptor activity adrenoceptor activity alpha1-adrenergic receptor activity Cellular component: integral to plasma membrane membrane Biological process: DNA metabolic process signal transduction G-protein coupled receptor protein signaling pathway G-protein signaling, coupled to cAMP nucleotide second messenger cell-cell signaling multicellular organismal development cell proliferation positive regulation of cell proliferation RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 146 11550 Ensembl ENSG00000171873 ENSMUSG00000027335 Uniprot P25100 P97714 Refseq NM_000678 mRNA NP_000669 protein NM_013460 mRNA NP_038488 protein Location Chr 20: 4.15 - 4.18 Mb Chr 2: 131.24 - 131.25 Mb Pubmed search 1 2 The alpha-1D adrenergic receptor α1D adrenoreceptor, also known as ADRA1D, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.1 Contents 1 Receptor 2 Gene 3 See also 4 References 5 Further reading Receptor There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells. Gene This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region.1 See also Adrenergic receptor References ^ a b Entrez Gene: ADRA1D adrenergic, alpha-1D-, receptor. Further reading Schwinn DA, Lomasney JW 1992. Pharmacologic characterization of cloned alpha 1-adrenoceptor subtypes: selective antagonists suggest the existence of a fourth subtype.. Eur. J. Pharmacol. 227 4: 433-6. PMID 1359975. Bruno JF, Whittaker J, Song JF, Berelowitz M 1991. Molecular cloning and sequencing of a cDNA encoding a human alpha 1A adrenergic receptor.. Biochem. Biophys. Res. Commun. 179 3: 1485-90. PMID 1656955. Esbenshade TA, Hirasawa A, Tsujimoto G, et al. 1995. Cloning of the human alpha 1d-adrenergic receptor and inducible expression of three human subtypes in SK-N-MC cells.. Mol. Pharmacol. 47 5: 977-85. PMID 7746284. Schwinn DA, Johnston GI, Page SO, et al. 1995. Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues.. J. Pharmacol. Exp. Ther. 272 1: 134-42. PMID 7815325. Weinberg DH, Trivedi P, Tan CP, et al. 1994. Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c.. Biochem. Biophys. Res. Commun. 201 3: 1296-304. PMID 8024574. Loftus SK, Shiang R, Warrington JA, et al. 1994. Genes encoding adrenergic receptors are not clustered on the long arm of human chromosome 5.. Cytogenet. Cell Genet. 67 2: 69-74. PMID 8039425. Yang-Feng TL, Han H, Lomasney JW, Caron MG 1994. Localization of the cDNA for an alpha 1-adrenergic receptor subtype ADRA1D to chromosome band 20p13.. Cytogenet. Cell Genet. 66 3: 170-1. PMID 8125015. Forray C, Bard JA, Wetzel JM, et al. 1994. The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype.. Mol. Pharmacol. 45 4: 703-8. PMID 8183249. Minneman KP, Lee D, Zhong H, et al. 2000. Transcriptional responses to growth factor and G protein-coupled receptors in PC12 cells: comparison of alpha1-adrenergic receptor subtypes.. J. Neurochem. 74 6: 2392-400. PMID 10820200. Keffel S, Alexandrov A, Goepel M, Michel MC 2000. alpha1-adrenoceptor subtypes differentially couple to growth promotion and inhibition in Chinese hamster ovary cells.. Biochem. Biophys. Res. Commun. 272 3: 906-11. doi:10.1006/bbrc.2000.2850. PMID 10860850. Kyprianou N, Benning CM 2000. Suppression of human prostate cancer cell growth by alpha1-adrenoceptor antagonists doxazosin and terazosin via induction of apoptosis.. Cancer Res. 60 16: 4550-5. PMID 10969806. Deloukas P, Matthews LH, Ashurst J, et al. 2002. The DNA sequence and comparative analysis of human chromosome 20.. Nature 414 6866: 865-71. doi:10.1038/414865a. PMID 11780052. Shibata K, Katsuma S, Koshimizu T, et al. 2003. alpha 1-Adrenergic receptor subtypes differentially control the cell cycle of transfected CHO cells through a cAMP-dependent mechanism involving p27Kip1.. J. Biol. Chem. 278 1: 672-8. doi:10.1074/jbc.M201375200. PMID 12409310. Pupo AS, Minneman KP 2004. Specific interactions between gC1qR and alpha1-adrenoceptor subtypes.. J. Recept. Signal Transduct. Res. 23 2-3: 185-95. PMID 14626446. Hague C, Uberti MA, Chen Z, et al. 2004. Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors.. J. Biol. Chem. 279 15: 15541-9. doi:10.1074/jbc.M314014200. PMID 14736874. Gonzalez-Cabrera PJ, Shi T, Yun J, et al. 2004. Differential regulation of the cell cycle by alpha1-adrenergic receptor subtypes.. Endocrinology 145 11: 5157-67. doi:10.1210/en.2004-0728. PMID 15297446. Zhang T, Xu Q, Chen FR, et al. 2005. Yeast two-hybrid screening for proteins that interact with alpha1-adrenergic receptors.. Acta Pharmacol. Sin. 25 11: 1471-8. PMID 15525470. Sigala S, Dellabella M, Milanese G, et al. 2005. Evidence for the presence of alpha1 adrenoceptor subtypes in the human ureter.. Neurourol. Urodyn. 24 2: 142-8. doi:10.1002/nau.20097. PMID 15690361. Chen Z, Hague C, Hall RA, Minneman KP 2006. Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction.. J. Biol. Chem. 281 18: 12414-20. doi:10.1074/jbc.M508651200. PMID 16533813. Michelotti GA, Brinkley DM, Morris DP, et al. 2007. Epigenetic regulation of human alpha1d-adrenergic receptor gene expression: a role for DNA methylation in Sp1-dependent regulation.. FASEB J. 21 9: 1979-93. doi:10.1096/fj.06-7118com. PMID 17384146. This transmembrane receptor-related article is a stub. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Alpha-1D_adrenergic_receptor Categories: Genes on chromosome 20 | Human proteins | Transmembrane receptor stubs | Adrenergic receptors | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 10:55
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