Sierra Acai Company
Sierra Acai Company
Open 7 Days a Week
MonaVie Independent Distributor
Distributor Training
Shop Online
Enroll Now
Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
Friends
Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
14-September-2008 18:02:41 - 2 Angiotensin II receptor, type 2 Identifiers Symbols AGTR2; AT2; ATGR2; MRX88 External IDs OMIM: 300034 MGI: 87966 HomoloGene: 20172 Gene ontology Molecular function: rhodopsin-like receptor activity protein kinase inhibitor activity receptor activity angiotensin type II receptor activity bradykinin receptor activity Cellular component: integral to plasma membrane membrane Biological process: angiotensin mediated vasodilation during regulation of blood pressure brain renin-angiotensin system apoptosis G-protein coupled receptor protein signaling pathway behavior blood pressure regulation RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 186 11609 Ensembl ENSG00000180772 ENSMUSG00000068122 Uniprot P50052 Q3US12 Refseq NM_000686 mRNA NP_000677 protein NM_007429 mRNA NP_031455 protein Location Chr X: 115.22 - 115.22 Mb Chr X: 20.64 - 20.65 Mb Pubmed search 1 2 Angiotensin II receptor type 2, also known as AGTR2, is a human gene.1 Angiotensin II is a potent pressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors termed AT1 and AT2. AGTR2 belongs to a family 1 of G protein-coupled receptors. It is an integral membrane protein. It plays a role in the central nervous system and cardiovascular functions that are mediated by the renin-angiotensin system. This receptor mediates programmed cell death apoptosis. In adults, it is highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. It is highly expressed in fetal kidney and intestine. The human AGTR2 gene is composed of three exons and spans at least 5 kb. Exons 1 and 2 encode for 5' untranslated mRNA sequence and exon 3 harbors the entire uninterrupted open reading frame.1 See also Angiotensin II receptor References ^ a b Entrez Gene: AGTR2 angiotensin II receptor, type 2. Further reading Regitz-Zagrosek V, Neuss M, Warnecke C, et al. 1997. Subtype 2 and atypical angiotensin receptors in the human heart.. Basic Res. Cardiol. 91 Suppl 2: 73-7. PMID 8957548. Berry C, Touyz R, Dominiczak AF, et al. 2002. Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide.. Am. J. Physiol. Heart Circ. Physiol. 281 6: H2337-65. PMID 11709400. Takayanagi R, Ohnaka K, Sakai Y, et al. 1992. Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor.. Biochem. Biophys. Res. Commun. 183 2: 910-6. PMID 1550596. Hein L, Barsh GS, Pratt RE, et al. 1995. Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice.. Nature 377 6551: 744-7. doi:10.1038/377744a0. PMID 7477266. Ichiki T, Labosky PA, Shiota C, et al. 1995. Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor.. Nature 377 6551: 748-50. doi:10.1038/377748a0. PMID 7477267. Lazard D, Briend-Sutren MM, Villageois P, et al. 1995. Molecular characterization and chromosome localization of a human angiotensin II AT2 receptor gene highly expressed in fetal tissues.. Recept. Channels 2 4: 271-80. PMID 7719706. Martin MM, Elton TS 1995. The sequence and genomic organization of the human type 2 angiotensin II receptor.. Biochem. Biophys. Res. Commun. 209 2: 554-62. doi:10.1006/bbrc.1995.1537. PMID 7733925. Chassagne C, Beatty BG, Meloche S 1995. Assignment of the human angiotensin II type 2 receptor gene AGTR2 to chromosome Xq22-q23 by fluorescence in situ hybridization.. Genomics 25 2: 601-3. PMID 7790004. Koike G, Horiuchi M, Yamada T, et al. 1994. Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung.. Biochem. Biophys. Res. Commun. 203 3: 1842-50. doi:10.1006/bbrc.1994.2402. PMID 7945336. Martin MM, Su B, Elton TS 1995. Molecular cloning of the human angiotensin II type 2 receptor cDNA.. Biochem. Biophys. Res. Commun. 205 1: 645-51. PMID 7999093. Tsuzuki S, Ichiki T, Nakakubo H, et al. 1994. Molecular cloning and expression of the gene encoding human angiotensin II type 2 receptor.. Biochem. Biophys. Res. Commun. 200 3: 1449-54. doi:10.1006/bbrc.1994.1613. PMID 8185599. Servant G, Boulay G, Bossé R, et al. 1993. Photoaffinity labeling of subtype 2 angiotensin receptor of human myometrium.. Mol. Pharmacol. 43 5: 677-83. PMID 8502225. Yamada T, Horiuchi M, Dzau VJ 1996. Angiotensin II type 2 receptor mediates programmed cell death.. Proc. Natl. Acad. Sci. U.S.A. 93 1: 156-60. PMID 8552595. Zhang J, Pratt RE 1996. The AT2 receptor selectively associates with Gialpha2 and Gialpha3 in the rat fetus.. J. Biol. Chem. 271 25: 15026-33. PMID 8663053. Katsuya T, Horiuchi M, Minami S, et al. 1997. Genomic organization and polymorphism of human angiotensin II type 2 receptor: no evidence for its gene mutation in two families of human premature ovarian failure syndrome.. Mol. Cell. Endocrinol. 127 2: 221-8. PMID 9099917. Akishita M, Ito M, Lehtonen JY, et al. 1999. Expression of the AT2 receptor developmentally programs extracellular signal-regulated kinase activity and influences fetal vascular growth.. J. Clin. Invest. 103 1: 63-71. PMID 9884335. Lehtonen JY, Daviet L, Nahmias C, et al. 1999. Analysis of functional domains of angiotensin II type 2 receptor involved in apoptosis.. Mol. Endocrinol. 13 7: 1051-60. PMID 10406457. Knowle D, Ahmed S, Pulakat L 2000. Identification of an interaction between the angiotensin II receptor sub-type AT2 and the ErbB3 receptor, a member of the epidermal growth factor receptor family.. Regul. Pept. 87 1-3: 73-82. PMID 10710290. Hansen JL, Servant G, Baranski TJ, et al. 2000. Functional reconstitution of the angiotensin II type 2 receptor and Gi activation.. Circ. Res. 87 9: 753-9. PMID 11055978. This article incorporates text from the United States National Library of Medicine, which is in the public domain. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened G protein-coupled receptors This membrane protein-related article is a stub. Retrieved from http://en..org/wiki/Angiotensin_II_receptor_type_2 Categories: Genes on chromosome X | Human proteins | Membrane protein stubsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 11:47
39 Reasons to Drink Acai Juice Every Day
What is MonaVie - Watch the 8-minute video
Discovering MonaVie Video
The Power of You Video
Effects of MonaVie Active on Antioxidant Capacity in Humans
Log into your Wholesale MonaVie Account
So many of us do not eat a balanced diet, get enough sleep, have too much stress, or are impacted with toxins and pollutants. Drinking 2 ounces of MonaVie twice a day will help your body detoxify as well as build your immune system. Its the smartest thing you can do for yourself, so start today. Buying MonaVie through our company guarantees you support 7 days a week and, if you would like to share MonaVie with your family and friends we will guide you from start to finish.
1. Click on Enroll Now (30 - 55% off retail price)
2. Pay $39 for your Wholesale ID number.
3. NO minimum order required.
4. MonaVie is delivered to your door in 3 to 5 days.