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14-September-2008 18:02:38 - Angiotensin-converting enzyme Angiotensin I converting enzyme peptidyl-dipeptidase A 1 PDB rendering based on 1o86. Available structures: 1o86, 1o8a, 1uze, 1uzf, 2c6f, 2c6n, 2iul, 2iux, 2oc2 Identifiers Symbols ACE; ACE1; CD143; DCP; DCP1; MGC26566 External IDs OMIM: 106180 MGI: 87874 HomoloGene: 37351 Gene ontology Molecular function: carboxypeptidase activity peptidyl-dipeptidase A activity zinc ion binding hydrolase activity, acting on glycosyl bonds chloride ion binding metal ion binding Cellular component: membrane fraction soluble fraction plasma membrane membrane integral to membrane Biological process: proteolysis metabolic process blood pressure regulation RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 1636 11421 Ensembl ENSG00000159640 ENSMUSG00000020681 Uniprot P12821 Q3TU20 Refseq NM_000789 mRNA NP_000780 protein NM_009598 mRNA NP_033728 protein Location Chr 17: 58.91 - 58.94 Mb Chr 11: 105.78 - 105.81 Mb Pubmed search 1 2 Angiotensin I converting enzyme ACE, EC 3.4.15.1 is an exopeptidase. Contents 1 Functions 2 Synonyms 3 Genetics 4 See also 5 References 6 Further reading 7 External links Functions It has two primary functions: it catalyses the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. 1 it is involved in the inactivation of bradykinin, a potent vasodilator. These two actions of ACE make it an ideal target in the treatment of conditions such as high blood pressure, heart failure, diabetic nephropathy and type 2 diabetes mellitus. Inhibition of ACE by ACE inhibitors results in decreased formation of Angiotensin II a far more potent vasoconstrictor than Angiotensin I and decreased inactivation of bradykinin. Synonyms ACE is also known as: peptidyl dipeptidase A carboxycathepsin kininase II kinin-kallikrein system CD 143 ACE1 Genetics The ACE gene, ACE, encodes 2 isozymes. The somatic isozyme is expressed in many tissues, mainly in the lung, including vascular endothelial cells, epithelial kidney cells, and testicular Leydig cells, whereas the germinal is expressed only in sperm. See also Renin-angiotensin system ACE inhibitors References ^ Physiology at MCG 7/7ch09/7ch09p16 Further reading Niu T, Chen X, Xu X 2002. Angiotensin converting enzyme gene insertion/deletion polymorphism and cardiovascular disease: therapeutic implications. Drugs 62 7: 977-93. doi:10.2165/00003495-200262070-00001. PMID 11985486. RoÄtberg GE, Tikhonravov AV, Dorosh ZhV 2004. Role of angiotensin-converting enzyme gene polymorphism in the development of metabolic syndrome. Ter. Arkh. 75 12: 72-7. PMID 14959477. Vynohradova SV 2005. The role of angiotensin-converting enzyme gene I/D polymorphism in development of metabolic disorders in patients with cardiovascular pathology. Tsitol. Genet. 39 1: 63-70. PMID 16018179. König S, Luger TA, Scholzen TE 2006. Monitoring neuropeptide-specific proteases: processing of the proopiomelanocortin peptides adrenocorticotropin and alpha-melanocyte-stimulating hormone in the skin. Exp. Dermatol. 15 10: 751-61. doi:10.1111/j.1600-0625.2006.00472.x. PMID 16984256. Sabbagh AS, Otrock ZK, Mahfoud ZR, et al. 2007. Angiotensin-converting enzyme gene polymorphism and allele frequencies in the Lebanese population: prevalence and review of the literature. Mol. Biol. Rep. 34 1: 47-52. doi:10.1007/s11033-006-9013-y. PMID 17103020. Castellon R, Hamdi HK 2007. Demystifying the ACE polymorphism: from genetics to biology. Curr. Pharm. Des. 13 12: 1191-8. doi:10.2174/138161207780618902. PMID 17504229. Lazartigues E, Feng Y, Lavoie JL 2007. The two fACEs of the tissue renin-angiotensin systems: implication in cardiovascular diseases. Curr. Pharm. Des. 13 12: 1231-45. doi:10.2174/138161207780618911. PMID 17504232. External links MeSH Angiotensin+Converting+Enzyme v d e Proteins: clusters of differentiation see also list of human clusters of differentiation 1-50 CD1 a-c, 1A, 1D, 1E - CD2 - CD3 γ, δ, ε - CD4 - CD5 - CD6 - CD7 - CD8 a - CD9 - CD10 - CD11 a, b, c - CD13 - CD14 - CD15 - CD16 A, B - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 A, B - CD33 - CD34 - CD35 - CD36 - CD37 - CD38 - CD39 - CD40 - CD41- CD42 a, b, c, d - CD43 - CD44 - CD45 - CD46 - CD47 - CD48 - CD49 a, b, c, d, e, f - CD50 51-100 CD51 - CD52 - CD53 - CD54 - CD55 - CD56 - CD57- CD58 - CD59 - CD61 - CD62 E, L, P - CD63 - CD64 - CD66 a, b, c, d, e, f - CD68 - CD69 - CD70 - CD71 - CD72 - CD73 - CD74 - CD79 a, b - CD80 - CD81 - CD82 - CD83 - CD84 - CD85 a, d, e, h, j, k - CD86 - CD87 - CD88 - CD89 - CD90 - CD91- CD92 - CD93 - CD94 - CD95 - CD97 - CD98 - CD99 - CD100 101-150 CD101 - CD102 - CD103 - CD104 - CD105 - CD106 - CD107 a, b - CD108 - CD109 - CD110 - CD111 - CD112 - CD113 - CD114 - CD115 - CD116 - CD117 - CD118 - CD119 - CD120 a, b - CD121 a, b - CD122 - CD123 - CD124 - CD125 - CD126 - CD127 - CD129 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD136 - CD137 - CD138 - CD140b - CD141 - CD142 - CD143 - CD144 - CD146 - CD147 - CD148 - CD150 151-200 CD151 - CD152 - CD153 - CD154 - CD155 - CD156 a, b, c - CD157 - CD158 a, d, e, i, k - CD159 a, c - CD160 - CD161 - CD162 - CD163 - CD164 - CD166 - CD167 a, b - CD168 - CD169 - CD170 - CD171 - CD172 a, b, g - CD174 - CD177 - CD178 - CD179 a, b - CD181 - CD182 - CD183 - CD184 - CD185 - CD186 - CD191 - CD192 - CD193 - CD194 - CD195 - CD196 - CD197 - CDw198 - CDw199 - CD200 201-250 CD201 - CD202b - CD204 - CD205 - CD206 - CD207 - CD208 - CD209 - CDw210 a, b - CD212 - CD213a 1, 2 - CD217 - CD218 a, b - CD220 - CD221 - CD222 - CD223 - CD224 - CD225 - CD226 - CD227 - CD228 - CD229 - CD230 - CD233 - CD234 - CD235 a, b - CD236 - CD238 - CD239 - CD240CE - CD241 - CD243 - CD244 - CD246 - CD247- CD248 - CD249 251-300 CD252 - CD253 - CD254 - CD256 - CD257 - CD258 - CD261 - CD262 - CD264 - CD265 - CD266 - CD267 - CD268 - CD269 - CD271 - CD272 - CD273 - CD274 - CD275 - CD276 - CD278 - CD279 - CD280 - CD281 - CD282 - CD283 - CD284 - CD286 - CD288 - CD289 - CD290 - CD292 - CDw293 - CD294 - CD295 - CD297 - CD298 - CD299 301-350 CD300A - CD304 - CD305 - CD307 - CD309 - CD312 - CD314 - CD315 - CD316 - CD317 - CD318 - CD320 - CD321 - CD322 - CD324 - CD325 - CD326 - CD328 - CD329 - CD331 - CD332 - CD333 - CD334 - CD335 - CD336 - CD337 - CD338 - CD339 - CD340 - CD344 - CD349 - CD350 v d e Hydrolase: proteases EC 3.4 Exopeptidase 3.4.11-19 Angiotensin-converting enzyme - Dipeptidase - Dipeptidyl peptidase-4 - DD-transpeptidase Metalloexopeptidases: Aminopeptidase Alanine, Arginyl, Aspartyl, Cystinyl, Leucyl, Glutamyl, Methionyl 1, 2, O - Carboxypeptidase A, B, C, E, Glutamate II Endopeptidase 3.4.21-24 Serine proteases - Cysteine protease - Aspartic acid protease - Metalloendopeptidases Cathepsin 3.4.18,21,22,23 A - B - C - D - E - F - G - H - K - L1/L2 - S - W - Z Retrieved from http://en..org/wiki/Angiotensin-converting_enzyme Categories: Genes on chromosome 17 | Human proteins | EC 3.4.15 | Kinin system Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Deutsch Español Français Nederlands 日本語 Polski Português СрпÑ?ки / Srpski This page was last modified on 8 July 2008, at 00:4
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