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14-September-2008 18:02:41 - 1B Arginine vasopressin receptor 1B Identifiers Symbols AVPR1B; AVPR3 External IDs OMIM: 600264 MGI: 1347010 HomoloGene: 22678 Gene ontology Molecular function: rhodopsin-like receptor activity receptor activity vasopressin receptor activity protein kinase C binding Cellular component: endosome plasma membrane integral to plasma membrane Biological process: signal transduction G-protein coupled receptor protein signaling pathway phospholipase C activation elevation of cytosolic calcium ion concentration Orthologs Human Mouse Entrez 553 26361 Ensembl ENSG00000198049 ENSMUSG00000026432 Uniprot P47901 Q9JLP2 Refseq NM_000707 mRNA NP_000698 protein NM_011924 mRNA NP_036054 protein Location Chr 1: 204.39 - 204.4 Mb Chr 1: 133.43 - 133.44 Mb Pubmed search 1 2 Arginine vasopressin receptor 1B AVPR1B, vasopressin 3 receptor is a protein that acts as receptor for arginine vasopressin. AVPR1B belongs to the subfamily of G-protein coupled receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. Contents 1 Tissue distribution 2 Clinical significance 2.1 Behavioral 2.2 Metabolic 2.3 Oncology 3 Ligands 4 References 5 External links Tissue distribution AVPR1B was initially described as a novel vasopressin receptor located in the anterior pituitary, where it stimulates ACTH release.1 Subsequent studies have shown its presence in the brain as well.23 Clinical significance Behavioral Inactivation of the Avpr1b in mice knockout produces mice with greatly reduced aggression and a reduced ability to recognize recently investigated mice.4 Interestingly, defensive behavior and predatory behaviors appear to normal in these knockout mice.5 There is evidence that social motivation or awareness is reduced in these mice.6 The AVPR1B antagonist, SSR149415, has been shown to have anti-aggressive actions in hamsters7 and anti-depressant- and anxiety anxiolytic-like behaviors in rats.8 A single nucleotide polymorphism SNP has been associated with susceptiblility to depression in man.9 Metabolic Various stress-induced elevations of ACTH are blunted in the Avpr1b knockout mouse.10 Oncology AVPR1B is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids11 responsible for the ectopic ACTH syndrome.12 Ligands SSR14941513 and D-Leu4-Lys8-vasopressin14 are a specific antagonist and agonist for the vasopressin 1b receptor, respectively. References ^ Antoni FA, Holmes MC, Makara GB, Kárteszi M, László FA 1984. Evidence that the effects of arginine-8-vasopressin AVP on pituitary corticotropin ACTH release are mediated by a novel type of receptor. Peptides 5 3: 519-22. doi:10.1016/0196-97818490080-9. PMID 6089144. ^ Hernando F, Schoots O, Lolait SJ, Burbach JP 2001. Immunohistochemical localization of the vasopressin V1b receptor in the rat brain and pituitary gland: anatomical support for its involvement in the central effects of vasopressin. Endocrinology 142 4: 1659-68. doi:10.1210/en.142.4.1659. PMID 11250948. ^ Young WS, Li J, Wersinger SR, Palkovits M 2006. The vasopressin 1b receptor is prominent in the hippocampal area CA2 where it is unaffected by restraint stress or adrenalectomy. Neuroscience 143 4: 1031-9. doi:10.1016/j.neuroscience.2006.08.040. PMID 17027167. ^ Wersinger SR, Ginns EI, O'Carroll AM, Lolait SJ, Young WS 2002. Vasopressin V1b receptor knockout reduces aggressive behavior in male mice. Mol. Psychiatry 7 9: 975-84. doi:10.1038/sj.mp.4001195. PMID 12399951. ^ Wersinger SR, Caldwell HK, Christiansen M, Young WS 2007. Disruption of the vasopressin 1b receptor gene impairs the attack component of aggressive behavior in mice. Genes Brain Behav. 6 7: 653-60. doi:10.1111/j.1601-183X.2006.00294.x. PMID 17284170. ^ Wersinger SR, Kelliher KR, Zufall F, Lolait SJ, O'Carroll AM, Young WS 2004. Social motivation is reduced in vasopressin 1b receptor null mice despite normal performance in an olfactory discrimination task. Hormones and Behavior 46 5: 638-45. doi:10.1016/j.yhbeh.2004.07.004. PMID 15555506. ^ Blanchard RJ, Griebel G, Farrokhi C, Markham C, Yang M, Blanchard DC 2005. AVP V1b selective antagonist SSR149415 blocks aggressive behaviors in hamsters. Pharmacol. Biochem. Behav. 80 1: 189-94. doi:10.1016/j.pbb.2004.10.024. PMID 15652395. ^ Serradeil-Le Gal C, Wagnon J, Tonnerre B, Roux R, Garcia G, Griebel G, Aulombard A 2005. An overview of SSR149415, a selective nonpeptide vasopressin V1b receptor antagonist for the treatment of stress-related disorders. CNS Drug Reviews 11 1: 53-68. doi:10.1111/j.1527-3458.2005.tb00035.x. PMID 15867952. ^ van West D, Del-Favero J, Aulchenko Y, Oswald P, Souery D, Forsgren T, Sluijs S, Bel-Kacem S, Adolfsson R, Mendlewicz J, Van Duijn C, Deboutte D, Van Broeckhoven C, Claes S 2004. A major SNP haplotype of the arginine vasopressin 1B receptor protects against recurrent major depression. Mol. Psychiatry 9 3: 287-92. doi:10.1038/sj.mp.4001420. PMID 15094789. ^ Lolait SJ, Stewart LQ, Jessop DS, Young WS, O'Carroll AM 2007. The hypothalamic-pituitary-adrenal axis response to stress in mice lacking functional vasopressin V1b receptors. Endocrinology 148 2: 849-56. doi:10.1210/en.2006-1309. PMID 17122081. ^ Arlt W, Dahia PL, Callies F, Nordmeyer JP, Allolio B, Grossman AB, Reincke M 1997. Ectopic ACTH production by a bronchial carcinoid tumour responsive to desmopressin in vivo and in vitro. Clin. Endocrinol. Oxf 47 5: 623-7. doi:10.1046/j.1365-2265.1997.3091129.x. PMID 9425403. ^ de Keyzer Y, Lenne F, Auzan C, Jégou S, René P, Vaudry H, Kuhn JM, Luton JP, Clauser E, Bertagna X 1996. The pituitary V3 vasopressin receptor and the corticotroph phenotype in ectopic ACTH syndrome. J. Clin. Invest. 97 5: 1311-8. PMID 8636444. ^ Serradeil-Le Gal C, Wagnon J, Simiand J, Griebel G, Lacour C, Guillon G, Barberis C, Brossard G, Soubrié P, Nisato D, Pascal M, Pruss R, Scatton B, Maffrand JP, Le Fur G 2002. Characterization of 2S,4R-1-5-chloro-1-2,4-dimethoxyphenylsulfonyl-3-2-methoxy-phenyl-2-oxo-2,3-dihydro-1H-indol-3-yl-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide SSR149415, a selective and orally active vasopressin V1b receptor antagonist. J. Pharmacol. Exp. Ther. 300 3: 1122-30. doi:10.1124/jpet.300.3.1122. PMID 11861823. ^ Pena A, Murat B, Trueba M, Ventura MA, Bertrand G, Cheng LL, Stoev S, Szeto HH, Wo N, Brossard G, Serradeil-Le Gal C, Manning M, Guillon G 2007. Pharmacological and physiological characterization of dLeu4, Lys8vasopressin, the first V1b-selective agonist for rat vasopressin/oxytocin receptors. Endocrinology 148 9: 4136-46. doi:10.1210/en.2006-1633. PMID 17495006. External links IUPHAR GPCR database - Arginine vasopressin receptor V1B MeSH Receptors,+Vasopressin v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened v d e Neuropeptide receptors Hypothalamic hormone receptors CRH - FSH - LHRH - TRH - Somatostatin Pituitary hormone receptors Vasopressin 1A, 1B, 2 - Oxytocin - LHCG - Type I cytokine receptor GH, Prolactin - TSH Other hormone receptors Atrial natriuretic factor - Calcitonin - Cholecystokinin A, B - VIP Opioid receptors Delta - Kappa - Mu - Sigma 1, 2 - Nociceptin Other neuropeptide receptors Angiotensin - Bradykinin B1, B2 / Tachykinin TACR1 - Calcitonin gene-related peptide - Galanin - GPCR neuropeptide B/W, FF, S, Y - Neurotensin Retrieved from http://en..org/wiki/Arginine_vasopressin_receptor_1B Categories: Genes on chromosome 1 | Human proteins | G protein coupled receptors | Cell signaling | Signal transductionHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 13 July 2008, at 13
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