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14-September-2008 18:02:41 - 3 adrenergic receptor Adrenergic, beta-3-, receptor Identifiers Symbols ADRB3; BETA3AR External IDs OMIM: 109691 MGI: 87939 HomoloGene: 37250 Gene ontology Molecular function: rhodopsin-like receptor activity receptor activity beta3-adrenergic receptor activity beta-3 adrenergic receptor binding protein homodimerization activity norepinephrine binding Cellular component: membrane fraction plasma membrane integral to plasma membrane receptor complex Biological process: diet induced thermogenesis norepinephrine-epinephrine vasodilation during regulation of blood pressure arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway carbohydrate metabolic process generation of precursor metabolites and energy energy reserve metabolic process receptor-mediated endocytosis signal transduction adenylate cyclase activation response to cold heat generation negative regulation of body size positive regulation of MAPKKK cascade brown fat cell differentiation RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 155 11556 Ensembl ENSG00000188778 ENSMUSG00000031489 Uniprot P13945 Q3UP63 Refseq NM_000025 mRNA NP_000016 protein NM_013462 mRNA NP_038490 protein Location Chr 8: 37.94 - 37.94 Mb Chr 8: 28.69 - 28.7 Mb Pubmed search 1 2 The beta-3 adrenergic receptor β3 adrenoreceptor, also known as ADRB3, is an beta-adrenergic receptor, and also denotes the human gene encoding it.1 Contents 1 Receptor 1.1 Functions 1.2 Mechanism 2 Agonists 3 Antagonists 4 See also 5 References 6 Further reading Receptor Functions Actions of the β3 receptor include: Enhancement of lipolysis in adipose tissue. Thermogenesis in skeletal muscle2 It is located mainly in adipose tissue and is involved in the regulation of lipolysis and thermogenesis. Some β3 agonists have demonstrated antidepressant effects in animal studies, suggesting it also has a role in the CNS. Mechanism Beta adrenergic receptors are involved in the epinephrine and norepinephrine-induced activation of adenylate cyclase through the action of the G proteins of the type Gs.1 Agonists Amibegron SR-58611A34 Solabegron GW-427,3535 L-796,5686 CL-316,2437 LY-368,842 Ro40-2148 Antagonists SR 59230A 8 See also Other adrenergic receptors Alpha-1 adrenergic receptor Alpha-2 adrenergic receptor Beta-1 adrenergic receptor Beta-2 adrenergic receptor References ^ a b Entrez Gene: ADRB1 adrenergic, beta-1-, receptor. ^ Rang, H. P. 2003. Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4. Page 163 ^ Consoli D, Leggio GM, Mazzola C, Micale V, Drago F. Behavioral effects of the beta3 adrenoceptor agonist SR58611A: is it the putative prototype of a new class of antidepressant/anxiolytic drugs? European Journal of Pharmacology. 2007 Nov 14;5731-3:139-47. PMID 17669397 ^ Overstreet DH, Stemmelin J, Griebel G. Confirmation of antidepressant potential of the selective beta3 adrenoceptor agonist amibegron in an animal model of depression. Pharmacology, Biochemistry and Behaviour. 2008 Jun;894:623-6. PMID 18358519 ^ Hicks A, McCafferty GP, Riedel E, Aiyar N, Pullen M, Evans C, Luce TD, Coatney RW, Rivera GC, Westfall TD, Hieble JP. GW427353 solabegron, a novel, selective beta3-adrenergic receptor agonist, evokes bladder relaxation and increases micturition reflex threshold in the dog. Journal of Pharmacology and Experimental Therapeutics. 2007 Oct;3231:202-9. PMID 17626794 ^ Larsen TM, Toubro S, van Baak MA, Gottesdiener KM, Larson P, Saris WH, Astrup A 2002. Effect of a 28-d treatment with L-796568, a novel β3-adrenergic receptor agonist, on energy expenditure and body composition in obese men. Am. J. Clin. Nutr. 76 4: 780-8. PMID 12324291. ^ Fu L, Isobe K, Zeng Q, Suzukawa K, Takekoshi K, Kawakami Y. The effects of beta3-adrenoceptor agonist CL-316,243 on adiponectin, adiponectin receptors and tumor necrosis factor-alpha expressions in adipose tissues of obese diabetic KKAy mice. European Journal of Pharmacology. 2008 Apr 14;5841:202-6. PMID 18304529 ^ Nisoli E, Tonello C, Landi M, Carruba MO 1996. Functional studies of the first selective β3-adrenergic receptor antagonist SR 59230A in rat brown adipocytes. Mol. Pharmacol. 49 1: 7-14. PMID 8569714. Further reading Granneman JG, Lahners KN, Rao DD 1993. Rodent and human beta 3-adrenergic receptor genes contain an intron within the protein-coding block.. Mol. Pharmacol. 42 6: 964-70. PMID 1336117. Nahmias C, Blin N, Elalouf JM, et al. 1991. Molecular characterization of the mouse beta 3-adrenergic receptor: relationship with the atypical receptor of adipocytes.. EMBO J. 10 12: 3721-7. PMID 1718744. Emorine LJ, Marullo S, Briend-Sutren MM, et al. 1989. Molecular characterization of the human beta 3-adrenergic receptor.. Science 245 4922: 1118-21. PMID 2570461. Guan XM, Amend A, Strader CD 1995. Determination of structural domains for G protein coupling and ligand binding in beta 3-adrenergic receptor.. Mol. Pharmacol. 48 3: 492-8. PMID 7565630. Rodriguez M, Carillon C, Coquerel A, et al. 1995. Evidence for the presence of beta 3-adrenergic receptor mRNA in the human brain.. Brain Res. Mol. Brain Res. 29 2: 369-75. PMID 7609625. Clément K, Vaisse C, Manning BS, et al. 1995. Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity.. N. Engl. J. Med. 333 6: 352-4. PMID 7609752. Dib A, Adélaïde J, Chaffanet M, et al. 1995. Characterization of the region of the short arm of chromosome 8 amplified in breast carcinoma.. Oncogene 10 5: 995-1001. PMID 7898940. Mahmoudian M 1994. The complex of human Gs protein with the beta 3 adrenergic receptor: a computer-aided molecular modeling study.. Journal of molecular graphics 12 1: 22-8, 34. PMID 8011597. Wilkie TM, Chen Y, Gilbert DJ, et al. 1994. Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors.. Genomics 18 2: 175-84. doi:10.1006/geno.1993.1452. PMID 8288218. Krief S, Lönnqvist F, Raimbault S, et al. 1993. Tissue distribution of beta 3-adrenergic receptor mRNA in man.. J. Clin. Invest. 91 1: 344-9. PMID 8380813. van Spronsen A, Nahmias C, Krief S, et al. 1993. The promoter and intron/exon structure of the human and mouse beta 3-adrenergic-receptor genes.. Eur. J. Biochem. 213 3: 1117-24. PMID 8389293. Lelias JM, Kaghad M, Rodriguez M, et al. 1993. Molecular cloning of a human beta 3-adrenergic receptor cDNA.. FEBS Lett. 324 2: 127-30. PMID 8389717. Candelore MR, Deng L, Tota LM, et al. 1996. Pharmacological characterization of a recently described human beta 3-adrenergic receptor mutant.. Endocrinology 137 6: 2638-41. PMID 8641219. Fujisawa T, Ikegami H, Yamato E, et al. 1996. Association of Trp64Arg mutation of the beta3-adrenergic-receptor with NIDDM and body weight gain.. Diabetologia 39 3: 349-52. PMID 8721782. Higashi K, Ishikawa T, Ito T, et al. 1997. Association of a genetic variation in the beta 3-adrenergic receptor gene with coronary heart disease among Japanese.. Biochem. Biophys. Res. Commun. 232 3: 728-30. doi:10.1006/bbrc.1997.6339. PMID 9126344. Hoffstedt J, Poirier O, Thörne A, et al. 1999. Polymorphism of the human beta3-adrenoceptor gene forms a well-conserved haplotype that is associated with moderate obesity and altered receptor function.. Diabetes 48 1: 203-5. PMID 9892244. Halushka MK, Fan JB, Bentley K, et al. 1999. Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.. Nat. Genet. 22 3: 239-47. doi:10.1038/10297. PMID 10391210. Kimura K, Sasaki N, Asano A, et al. 2000. Mutated human beta3-adrenergic receptor Trp64Arg lowers the response to beta3-adrenergic agonists in transfected 3T3-L1 preadipocytes.. Horm. Metab. Res. 32 3: 91-6. PMID 10786926. Cao W, Luttrell LM, Medvedev AV, et al. 2001. Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation.. J. Biol. Chem. 275 49: 38131-4. doi:10.1074/jbc.C000592200. PMID 11013230. Russell ST, Hirai K, Tisdale MJ 2002. Role of beta3-adrenergic receptors in the action of a tumour lipid mobilizing factor.. Br. J. Cancer 86 3: 424-8. doi:10.1038/sj.bjc.6600086. PMID 11875710. This transmembrane receptor-related article is a stub. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Beta-3_adrenergic_receptor Categories: Genes on chromosome 8 | Human proteins | Transmembrane receptor stubs | Adrenergic receptors | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 19 August 2008, at 22:17
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