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14-September-2008 18:02:35 - Blood For other uses, see Blood disambiguation. Human blood smear: a - erythrocytes; b - neutrophil;c - eosinophil; d - lymphocyte. Human blood smear: a - erythrocytes; b - neutrophil; c - eosinophil; d - lymphocyte. A scanning electron microscope SEM image of a normal red blood cell, a platelet, and a white blood cell. A scanning electron microscope SEM image of a normal red blood cell, a platelet, and a white blood cell. Blood is a specialized bodily fluid technically a tissue. In vertebrates it is composed of blood cells suspended in a liquid called blood plasma. Plasma, which comprises 55% of blood fluid, is mostly water 90% by volume, and contains dissolved proteins, glucose, mineral ions, hormones, carbon dioxide plasma being the main medium for excretory product transportation, platelets and blood cells themselves. The blood cells present in blood are mainly red blood cells also called RBCs or erythrocytes and white blood cells, including leukocytes and platelets also called thrombocytes. The most abundant cells in vertebrate blood are red blood cells. These contain hemoglobin, an iron-containing protein, which facilitates transportation of oxygen by reversibly binding to this respiratory gas and greatly increasing its solubility in blood. In contrast, carbon dioxide is almost entirely transported extracellularly dissolved in plasma as bicarbonate ion. Vertebrate blood is bright red when its hemoglobin is oxygenated. Some animals, such as crustaceans and mollusks, use hemocyanin to carry oxygen, instead of hemoglobin. Insects and some molluscs use a fluid called hemolymph instead of blood, the difference being that hemolymph is not contained in a closed circulatory system. In most insects, this blood does not contain oxygen-carrying molecules such as hemoglobin because their bodies are small enough that their tracheal system suffices for supplying oxygen. Jawed vertebrates have an adaptive immune system, based largely on white blood cells. White blood cells help to resist infections and parasites. Platelets are important in the clotting of blood.1 Arthropods, using hemolymph, have hemocytes as part of their immune system. Blood is circulated around the body through blood vessels by the pumping action of the heart. In animals having lungs, arterial blood carries oxygen from inhaled air to the tissues of the body, and venous blood carries carbon dioxide, a waste product of metabolism produced by cells, from the tissues to the lungs to be exhaled. Medical terms related to blood often begin with hemo- or hemato- BrE: haemo- and haemato- from the Greek word αἷμα for blood. Anatomically and histologically, blood is considered a specialized form of connective tissue, given its origin in the bones and the presence of potential molecular fibers in the form of fibrinogen. Blood circulation:Red = oxygenatedBlue = deoxygenated Blood circulation: Red = oxygenated Blue = deoxygenated Contents 1 Functions 2 Constituents of human blood 2.1 Cells 2.2 Plasma 3 Physiology 3.1 Cardiovascular system 3.2 Production and degradation of blood cells 3.3 Oxygen transport 3.4 Carbon dioxide transport 3.5 Transport of hydrogen ions 3.6 Lymphatic system 3.7 Thermoregulation 3.8 Hydraulic functions 3.9 Invertebrates 4 Color 4.1 Hemoglobin 4.2 Hemocyanin 4.3 Vacuum 5 Pathology 5.1 General medical disorders 5.2 Hematological disorders 5.3 Carbon monoxide poisoning 6 Medical treatments 6.1 Blood products 6.2 Intravenous administration 6.3 Bloodletting 7 History 7.1 Classical Greek medicine 7.2 Hippocratic medicine 8 Myths, beliefs and religion 8.1 Indigenous Australians 8.2 Indo-European paganism 8.3 Judaism 8.4 Christianity 8.5 Islam 8.6 Jehovah's Witnesses 8.7 Chinese and Japanese culture 8.8 Blood libel 8.9 Vampire legends 9 Entertainment 9.1 Art 9.2 Films 10 See also 11 References 12 External links Functions Hemoglobingreen = heme groupsred blue = protein subunits Hemoglobin green = heme groups red blue = protein subunits Heme Heme Blood performs many important functions within the body including: Supply of oxygen to tissues bound to hemoglobin which is carried in red cells Supply of nutrients such as glucose, amino acids and fatty acids dissolved in the blood or bound to plasma proteins eg blood lipids Removal of waste such as carbon dioxide, urea and lactic acid Immunological functions, including circulation of white cells, and detection of foreign material by antibodies Coagulation, which is one part of the body's self-repair mechanism Messenger functions, including the transport of hormones and the signaling of tissue damage Regulation of body pH the normal pH of blood is in the range of 7.35 - 7.45 Regulation of core body temperature Hydraulic functions Constituents of human blood See also: Reference ranges for common blood tests Two tubes of EDTA anticoagulated blood.Left tube: after standing, the RBCs have settled at the bottom of the tube.Right tube: contains freshly drawn blood. Two tubes of EDTA anticoagulated blood. Left tube: after standing, the RBCs have settled at the bottom of the tube. Right tube: contains freshly drawn blood. Blood accounts for 7% of the human body weight,2 with an average density of approximately 1060 kg/m³, very close to pure water's density of 1000 kg/m3.3 The average adult has a blood volume of roughly 5 litres, composed of plasma and several kinds of cells occasionally called corpuscles; these formed elements of the blood are erythrocytes red blood cells, leukocytes white blood cells and thrombocytes platelets. By volume the red blood cells constitute about 45% of whole blood, the plasma constitutes about 55%, and white cells constitute a minute volume. Whole blood plasma and cells exhibits non-Newtonian fluid dynamics; its flow properties are adapted to flow effectively through tiny capillary blood vessels with less resistance than plasma by itself. In addition, if all human hemoglobin was free in the plasma rather than being contained in RBCs, the circulatory fluid would be too viscous for the cardiovascular system to function effectively. Cells Further information: Complete blood count One microliter of blood contains: 4.7 to 6.1 million male, 4.2 to 5.4 million female erythrocytes:4 In mammals, mature red blood cells lack a nucleus and organelles. They contain the blood's hemoglobin and distribute oxygen. The red blood cells together with endothelial vessel cells and other cells are also marked by glycoproteins that define the different blood types. The proportion of blood occupied by red blood cells is referred to as the hematocrit, and is normally about 45%. The combined surface area of all the red cells in the human body would be roughly 2,000 times as great as the body's exterior surface.5 4,000-11,000 leukocytes:6 White blood cells are part of the immune system; they destroy and remove old or aberrant cells and cellular debris, as well as attack infectious agents pathogens and foreign substances. The cancer of leukocytes is called leukemia. 200,000-500,000 thrombocytes:6 thrombocytes, also called platelets, are responsible for blood clotting coagulation. They change fibrinogen into fibrin. This fibrin creates a mesh onto which red blood cells collect and clot, which then stops more blood from leaving the body and also helps to prevent bacteria from entering the body. Constitution of normal blood Parameter Value Hematocrit 45 ± 7 38-52% for males 42 ± 5 37-47% for females pH 7.35-7.45 base excess -3 to +3 PO2 10-13kPa 80-100 mmHg PCO2 4.8kPa - 5.8kPa 35-45 mmHg HCO3- 21mM - 27mM Oxygen saturation Oxygenated: 98-99% Deoxygenated: 75% Plasma About 55% of whole blood is blood plasma, a fluid that is the blood's liquid medium, which by itself is straw-yellow in color. The blood plasma volume totals of 2.7-3.0 litres in an average human. It is essentially an aqueous solution containing 92% water, 8% blood plasma proteins, and trace amounts of other materials. Plasma circulates dissolved nutrients, such as, glucose, amino acids and fatty acids dissolved in the blood or bound to plasma proteins, and removes waste products, such as, carbon dioxide, urea and lactic acid. Other important components include: Serum albumin Blood clotting factors to facilitate coagulation Immunoglobulins antibodies lipoprotein particles Various other proteins Various electrolytes mainly sodium and chloride The term serum refers to plasma from which the clotting proteins have been removed. Most of the proteins remaining are albumin and immunoglobulins. The normal pH of human arterial blood is approximately 7.40 normal range is 7.36-7.44, a weak alkaline solution. Blood that has a pH below 7.35 is too acidic, while blood pH above 7.45 is too alkaline. Blood pH, partial pressure of oxygen PaO2, partial pressure of carbon dioxidePaCO2 and HCO3 are carefully regulated by a number of homeostatic mechanisms, which principally exert their influence through influence the respiratory system and the urinary system in the control the acid-base balance and respiration. Plasma also circulates hormones transmitting their messages to various tissues. The list of normal reference ranges for various blood electrolytes is extensive. Physiology Cardiovascular system The circulation of blood through the human heart The circulation of blood through the human heart Main article: Circulatory system Blood is circulated around the body through blood vessels by the pumping action of the heart. In humans, blood is pumped from the strong left ventricle of the heart through arteries to peripheral tissues and returns to the right atrium of the heart through veins. It then enters the right ventricle and is pumped through the pulmonary artery to the lungs and returns to the left atrium through the pulmonary veins. Blood then enters the left ventricle to be circulated again. Arterial blood carries oxygen from inhaled air to all of the cells of the body, and venous blood carries carbon dioxide, a waste product of metabolism by cells, to the lungs to be exhaled. However, one exception includes pulmonary arteries which contains the most deoxygenated blood in the body, while the pulmonary veins contain oxygenated blood. Additional return flow may be generated by the movement of skeletal muscles which can compress veins and push blood through the valves in veins towards the right atrium. The blood circulation was famously described by William Harvey in 1628.7 Production and degradation of blood cells In vertebrates, the various cells of blood are made in the bone marrow in a process called hematopoiesis, which includes erythropoiesis, the production of red blood cells; and myelopoiesis, the production of white blood cells and platelets. During childhood, almost every human bone produces red blood cells; as adults, red blood cell production is limited to the larger bones: the bodies of the vertebrae, the breastbone sternum, the ribcage, the pelvic bones, and the bones of the upper arms and legs. In addition, during childhood, the thymus gland, found in the mediastinum, is an important source of lymphocytes.8 The proteinaceous component of blood including clotting proteins is produced predominantly by the liver, while hormones are produced by the endocrine glands and the watery fraction is regulated by the hypothalamus and maintained by the kidney. Healthy erythrocytes have a plasma life of about 120 days before they are degraded by the spleen, and the Kupffer cells in the liver. The liver also clears some proteins, lipids and amino acids. The kidney actively secretes waste products into the urine. Oxygen transport Basic hemoglobin saturation curve. It is moved to the right in higher acidity more dissolved carbon dioxide and to the left in lower acidity less dissolved carbon dioxide Basic hemoglobin saturation curve. It is moved to the right in higher acidity more dissolved carbon dioxide and to the left in lower acidity less dissolved carbon dioxide Further information: Oxygen transportation About 98.5% of the oxygen in a sample of arterial blood in a healthy human breathing air at sea-level pressure is chemically combined with the Hgb. About 1.5% is physically dissolved in the other blood liquids and not connected to Hgb. The hemoglobin molecule is the primary transporter of oxygen in mammals and many other species for exceptions, see below. With the exception of pulmonary and umbilical arteries and their corresponding veins, arteries carry oxygenated blood away from the heart and deliver it to the body via arterioles and capillaries, where the oxygen is consumed; afterwards, venules and veins carry deoxygenated blood back to the heart. Under normal conditions in humans at rest, hemoglobin in blood leaving the lungs is about 98-99% saturated with oxygen. In a healthy adult at rest, deoxygenated blood returning to the lungs is still approximately 75% saturated.910 Increased oxygen consumption during sustained exercise reduces the oxygen saturation of venous blood, which can reach less than 15% in a trained athlete; although breathing rate and blood flow increase to compensate, oxygen saturation in arterial blood can drop to 95% or less under these conditions.11 Oxygen saturation this low is considered dangerous in an individual at rest for instance, during surgery under anesthesia. Sustained hypoxia,oxygenation of less than 90% is dangerous to health, and severe hypoxia saturations of less than 30% may be rapidly fatal.12 A fetus, receiving oxygen via the placenta, is exposed to much lower oxygen pressures about 21% of the level found in an adult's lungs and so fetuses produce another form of hemoglobin with a much higher affinity for oxygen hemoglobin F in order to function under these conditions.13 Carbon dioxide transport When blood flows through capillaries, carbon dioxide diffuses from the tissues into the blood. Some carbon dioxide is dissolved in the blood. Some carbon dioxide reacts with hemoglobin and other proteins to form carbamino compounds. The remaining carbon dioxide is converted to bicarbonate and hydrogen ions through the action of RBC carbonic anhydrase. Most carbon dioxide is transported through the blood in the form of bicarbonate ions. Carbon dioxide CO2, the main cellular waste product is carried in blood mainly dissolved in plasma, in equilibrium with bicarbonate HCO3- and carbonic acid H2CO3. 86%-90% of CO2 in the body is converted into carbonic acid, which can quickly turn into bicarbonate, the chemical equilibrium being important in the pH buffering of plasma.14 Blood pH is kept in a narrow range pH between 7.35-7.45.15 Transport of hydrogen ions Some oxyhemoglobin loses oxygen and becomes deoxyhemoglobin. Deoxyhemoglobin binds most of the hydrogen ions as it has a much greater affinity for more hydrogen than does oxyhemoglobin. Lymphatic system Main article: Lymphatic system In mammals, blood is in equilibrium with lymph, which is continuously formed in tissues from blood by capillary ultrafiltration. Lymph is collected by a system of small lymphatic vessels and directed to the thoracic duct, which drains into the left subclavian vein where lymph rejoins the systemic blood circulation. Thermoregulation Blood circulation transports heat throughout the body, and adjustments to this flow are an important part of thermoregulation. Increasing blood flow to the surface e.g. during warm weather or strenuous exercise causes warmer skin, resulting in faster heat loss, while decreasing surface blood flow conserves heat. Hydraulic functions The restriction of blood flow can also be used in specialized tissues to cause engorgement resulting in an erection of that tissue; examples are the erectile tissue in the penis, nipples or clitoris. Another example of a hydraulic function is the jumping spider, in which blood forced into the legs under pressure causes them to straighten for a powerful jump, without the need for bulky muscular legs.16 Invertebrates In insects, the blood more properly called hemolymph is not involved in the transport of oxygen. Openings called tracheae allow oxygen from the air to diffuse directly to the tissues. Insect blood moves nutrients to the tissues and removes waste products in an open system. Other invertebrates use respiratory proteins to increase the oxygen carrying capacity. Hemoglobin is the most common respiratory protein found in nature. Hemocyanin blue contains copper and is found in crustaceans and mollusks. It is thought that tunicates sea squirts might use vanabins proteins containing vanadium for respiratory pigment bright green, blue, or orange. In many invertebrates, these oxygen-carrying proteins are freely soluble in the blood; in vertebrates they are contained in specialized red blood cells, allowing for a higher concentration of respiratory pigments without increasing viscosity or damaging blood filtering organs like the kidneys. Giant tube worms have unusual hemoglobins that allow them to live in extraordinary environments. These hemoglobins also carry sulfides normally fatal in other animals. Color Hemoglobin A bleeding finger A bleeding finger Hemoglobin is the principal determinant of the color of blood in vertebrates. Each molecule has four heme groups, and their interaction with various molecules alters the exact color. In vertebrates and other hemoglobin-using creatures, arterial blood and capillary blood are bright red as oxygen imparts a strong red color to the heme group. Deoxygenated blood is a darker shade of red; this is present in veins, and can be seen during blood donation and when venous blood samples are taken. Blood in carbon monoxide poisoning is bright red, because carbon monoxide causes the formation of carboxyhemoglobin. In cyanide poisoning, the body cannot utilize oxygen, so the venous blood remains oxygenated, increasing the redness. While hemoglobin containing blood is never blue, there are several conditions and diseases where the color of the heme groups make the skin appear blue. If the heme is oxidized, methemoglobin, which is more brownish and cannot transport oxygen, is formed. In the rare condition sulfhemoglobinemia, arterial hemoglobin is partially oxygenated, and appears dark-red with a bluish hue cyanosis. Veins in the skin appear blue for a variety of reasons only weakly dependent on the color of the blood. Light scattering in the skin, and the visual processing of color play roles as well.17 Skinks in the genus Prasinohaema have green blood due to a buildup of the waste product biliverdin.18 Hemocyanin The blood of most molluscs - including cephalopods and gastropods - as well as some arthropods, such as horseshoe crabs, is blue, as it contains the copper-containing protein hemocyanin at concentrations of about 50 grams per litre.19 Hemocyanin is colourless when deoxygenated and dark blue when oxygenated. The blood in the circulation of these creatures, which generally live in cold environments with low oxygen tensions, is grey-white to pale yellow,19 and it turns dark blue when exposed to the oxygen in the air, as seen when they bleed.19 This is due to change in color of hemocyanin when is it oxidized.19 Hemocyanin carries oxygen in extracellular fluid, which is in contrast to the intracellular oxygen transport in mammals by hemoglobin in RBCs.19 Vacuum If human blood was exposed to vacuum, it would lose all oxygen bound to the hemoglobin molecules in its red cells as it does in part when it supplies oxygen to various organs as it passes through the body. This state of deoxyhemoglobin has a purplish colour. Pathology General medical disorders Disorders of volume Injury can cause blood loss through bleeding20. A healthy adult can lose almost 20% of blood volume 1L before the first symptom, restlessness, begins, and 40% of volume 2L before shock sets in. Thrombocytes are important for blood coagulation and the formation of blood clots which can stop bleeding. Trauma to the internal organs or bones can cause internal bleeding, which can sometimes be severe. Dehydration can reduce the blood volume by reducing the water content of the blood. This would rarely result in shock apart from the very severe cases but may result in orthostatic hypotension and fainting. Disorders of circulation Shock is the ineffective perfusion of tissues, and can be caused by a variety of conditions including blood loss, infection, poor cardiac output. Atherosclerosis reduces the flow of blood through arteries, because atheroma lines arteries and narrows them. Atheroma tends to increase with age, and its progression can be compounded by many causes including smoking, high blood pressure, excess circulating lipids hyperlipidemia, and diabetes mellitus. Coagulation can form a thrombosis which can obstruct vessels. Problems with blood composition, the pumping action of the heart, or narrowing of blood vessels can have many consequences including hypoxia lack of oxygen of the tissues supplied. The term ischemia refers to tissue which is inadequately perfused with blood, and infarction refers to tissue death necrosis which can occur when the blood supply has been blocked or is very inadequate. Hematological disorders See also: Hematology Anemia Insufficient red cell mass anemia can be the result of bleeding, blood diseases like thalassemia, or nutritional deficiencies; and may require blood transfusion. Several countries have blood banks to fill the demand for transfusable blood. A person receiving a blood transfusion must have a blood type compatible with that of the donor. Sickle-cell anemia Disorders of cell proliferation Leukemia is a group of cancers of the blood-forming tissues. Non-cancerous overproduction of red cells polycythemia vera or platelets essential thrombocytosis may be premalignant. Myelodysplastic syndromes involve ineffective production of one or more cell lines. Disorders of coagulation Hemophilia is a genetic illness that causes dysfunction in one of the blood's clotting mechanisms. This can allow otherwise inconsequential wounds to be life-threatening, but more commonly results in hemarthrosis, or bleeding into joint spaces, which can be crippling. Ineffective or insufficient platelets can also result in coagulopathy bleeding disorders. Hypercoagulable state thrombophilia results from defects in regulation of platelet or clotting factor function, and can cause thrombosis. Infectious disorders of blood Blood is an important vector of infection. HIV, the virus which causes AIDS, is transmitted through contact with blood, semen or other body secretions of an infected person. Hepatitis B and C are transmitted primarily through blood contact. Owing to blood-borne infections, bloodstained objects are treated as a biohazard. Bacterial infection of the blood is bacteremia or sepsis. Viral Infection is viremia. Malaria and trypanosomiasis are blood-borne parasitic infections. Carbon monoxide poisoning Main article: Carbon monoxide poisoning Substances other than oxygen can bind to hemoglobin; in some cases this can cause irreversible damage to the body. Carbon monoxide, for example, is extremely dangerous when carried to the blood via the lungs by inhalation, because carbon monoxide irreversibly binds to hemoglobin to form carboxyhemoglobin, so that less hemoglobin is free to bind oxygen, and less oxygen can be transported in the blood. This can cause suffocation insidiously. A fire burning in an enclosed room with poor ventilation presents a very dangerous hazard since it can create a build-up of carbon monoxide in the air. Some carbon monoxide binds to hemoglobin when smoking tobacco. Medical treatments Blood products Further information: Blood transfusion Blood for transfusion is obtained from human donors by blood donation and stored in a blood bank. There are many different blood types in humans, the ABO blood group system, and the Rhesus blood group system being the most important. Transfusion of blood of an incompatible blood group may cause severe, often fatal, complications, so crossmatching is done to ensure that a compatible blood product is transfused. Other blood products administered intravenously are platelets, blood plasma, cryoprecipitate and specific coagulation factor concentrates. Intravenous administration Many forms of medication from antibiotics to chemotherapy are administered intravenously, as they are not readily or adequately absorbed by the digestive tract. After severe acute blood loss, liquid preparations, generically known as plasma expanders, can be given intravenously, either solutions of salts NaCl, KCl, CaCl2 etc... at physiological concentrations, or colloidal solutions, such as dextrans, human serum albumin, or fresh frozen plasma. In these emergency situations, a plasma expander is a more effective life saving procedure than a blood transfusion, because the metabolism of transfused red blood cells does not restart immediately after a transfusion. Bloodletting Main article: bloodletting In modern evidence-based medicine bloodletting is used in management of a few rare diseases, including hemochromatosis and polycythemia. However, bloodletting and leeching were common unvalidated interventions used until the 19th century, as many diseases were incorrectly thought to be due to an excess of blood, according to Hippocratic medicine. History Classical Greek medicine In classical Greek medicine, blood was associated with air, springtime, and with a merry and gluttonous sanguine personality. It was also believed to be produced exclusively by the liver. Hippocratic medicine In Hippocratic medicine, blood was considered to be one of the four humors, together with phlegm, yellow bile and black bile. Myths, beliefs and religion Due to its importance to life, blood is associated with a large number of beliefs. One of the most basic is the use of blood as a symbol for family relationships; to be related by blood is to be related by ancestry or descendance, rather than marriage. This bears closely to bloodlines, and sayings such as blood is thicker than water and bad blood, as well as Blood brother. Blood is given particular emphasis in the Jewish and Christian religions because Leviticus 17:11 says the life of a creature is in the blood. This phrase is part of the Levitical law forbidding the drinking of blood, due to its practice in idol worship by surrounding societies. Mythic references to blood can sometimes be connected to the living-giving nature of blood, seen in such events as childbirth, as contrasted with the blood of injury or death. Indigenous Australians In many indigenous Australian Aboriginal peoples' traditions, ochre particularly red and blood, both high in iron content and considered Maban, are applied to the bodies of dancers for ritual. As Lawlor states: In many Aboriginal rituals and ceremonies, red ochre is rubbed all over the naked bodies of the dancers. In secret, sacred male ceremonies, blood extracted from the veins of the participant's arms is exchanged and rubbed on their bodies. Red ochre is used in similar ways in less secret ceremonies. Blood is also used to fasten the feathers of birds onto people's bodies. Bird feathers contain a protein that is highly magnetically sensitive.21 Lawlor comments that blood employed in this fashion is held by these peoples to attune the dancers to the invisible energetic realm of the Dreamtime. Lawlor then connects these invisible energetic realms and magnetic fields, because iron is magnetic. Indo-European paganism Among the Germanic tribes such as the Anglo-Saxons and the Norsemen, blood was used during their sacrifices; the Blóts. The blood was considered to have the power of its originator and after the butchering the blood was sprinkled on the walls, on the statues of the gods and on the participants themselves. This act of sprinkling blood was called bleodsian in Old English and the terminology was borrowed by the Roman Catholic Church becoming to bless and blessing. The Hittite word for blood, ishar was a cognate to words for oath and bond, see Ishara. The Ancient Greeks believed that the blood of the Gods, ichor, was a mineral that was poisonous to mortals. Judaism In Judaism, blood cannot be consumed even in the smallest quantity Leviticus 3:17 and elsewhere; this is reflected in Jewish dietary laws Kashrut. Blood is purged from meat by salting and soaking in water. Other rituals involving blood are the covering of the blood of fowl and game after slaughtering Leviticus 17:13; the reason given by the Torah is: Because the life of every animal is in his blood ibid 17:14. Christianity Main article: Eucharist Some Christian churches, including Roman Catholicism, Eastern Orthodoxy, Anglicanism teach that, when consecrated, the Eucharistic wine actually becomes the material blood of Jesus. Thus in the consecrated wine, Jesus becomes spiritually and physically present. This teaching is rooted in the Last Supper as written in the four gospels of the Bible, in which Jesus stated to his disciples that the bread which they ate was his body, and the wine was his blood. This cup is the new testament in my blood, which is shed for you. Luke 22:20. Various forms of Protestantism, especially those of a Wesleyan or Presbyterian lineage, teach that the wine is no more than a symbol of the blood of Christ, who is spiritually but not physically present. Lutheran theology teaches that the body and blood is present together in, with, and under the bread and wine of the Eucharistic feast. Christ's blood is also seen as the means for atonement for sins for Christians. At the Council of Jerusalem, the apostles prohibited Christians from consuming blood, probably because this was a command given to Noah Genesis 9:4, see Noahide Law. This command continued to be observed by the Eastern Orthodox. Islam Consumption of food containing blood is forbidden by Islamic dietary laws. This is derived from the statement in the Qur'an, sura Al-Ma'ida 5:3: Forbidden to you for food are: dead meat, blood, the flesh of swine, and that on which hath been invoked the name of other than Allah. Jehovah's Witnesses Main article: Jehovah's Witnesses and blood Due to Bible-based beliefs, Jehovah's Witnesses do not eat blood or accept transfusions of whole blood or its four major components namely, red blood cells, white blood cells, platelets thrombocytes, and whole plasma. Members are instructed to personally decide whether or not to accept fractions, and medical procedures that involve their own blood. Chinese and Japanese culture In Chinese culture, it is often said that if a man's nose produces a small flow of blood, this signifies that he is experiencing sexual desire. This often appears in Chinese-language and Hong Kong films as well as in Japanese culture parodied in anime and manga. Characters, mostly males, will often be shown with a nosebleed if they have just seen someone nude or in little clothing, or if they have had an erotic thought or fantasy.22 Blood libel Main article: Blood libel Various religious and other groups have been falsely accused of using human blood in rituals; such accusations are known as blood libel. The most common form of this is blood libel against Jews. Although there is no ritual involving human blood in Jewish law or custom, fabrications of this nature often involving the murder of children were widely used during the Middle Ages to justify Antisemitic persecution and some have persisted into the 21st century. Vampire legends Main article: Vampire Vampires are mythological beings which live forever by drinking the blood of the living. Stories of creatures of this kind are known all over the world. Most of these myths in Western culture originate from Eastern European folklore. Entertainment Art Blood is one of the body fluids that has been used in art.23 In particular, the performances of Viennese Actionist Hermann Nitsch, Franko B, Lennie Lee, Ron Athey, Yang Zhichao and Kira O' Reilly along with the photography of Andres Serrano, have incorporated blood as a prominent visual element. Marc Quinn has made sculptures using frozen blood, including a cast of his own head made using his own blood. Blood is also the main leitmotiv in Maligno Art. Films Blood is commonly associated with gore in motion pictures. Films with bloody scenes tend to receive a high rating by film licensing bodies, ranging from PG-13 to NC-17, depending on its depiction and its prominence. Blood in video games has led to video game censorship.citation needed See also Blood donation Blood substitutes Artificial blood Blood test List of human blood components Blood as food: see black pudding and tiết canh Taboo food and drink: Blood Hemophobia Autotransfusion References ^ Maton, Anthea; Jean Hopkins, Charles William McLaughlin, Susan Johnson, Maryanna Quon Warner, David LaHart, Jill D. Wright 1993. Human Biology and Health. Englewood Cliffs, New Jersey, USA: Prentice Hall. ISBN 0-13-981176-1. ^ Alberts, Bruce 2005. Leukocyte functions and percentage breakdown. Molecular Biology of the Cell. NCBI Bookshelf. Retrieved on 2007-04-14. ^ Shmukler, Michael 2004. Density of Blood. The Physics Factbook. Retrieved on 2006-10-04. ^ Medical Encyclopedia: RBC count. Medline Plus. Retrieved on 18 November 2007. ^ Martini, Frederic, et al 2006. Human Anatomy. 5th ed. Page 529. San Francisco, California: Pearson Education, Inc. ISBN 0-8053-7211-3 ^ a b Ganong, William F.: Review of medical physiology, twenty first ion, page 518 ^ Harvey, William 1628. Exercitatio Anatomica de Motu Cordis et Sanguinis in Animalibus in Latin. ^ P.Williams, R.Warwick, M.Dyson,L.Bannister eds,Gray's Anatomy 37th ed., Churchill Livingstone, Edinburgh 1989 ^ Ventilation and Endurance Performance ^ Transplant Support- Lung, Heart/Lung, Heart MSN groups ^ J Physiol. 2005 July 1 ^ The 'St George' Guide To Pulmonary Artery Catheterisation ^ Oxygen Carriage in Blood - High Altitude ^ Biology.arizona.edu. October 2006. Clinical correlates of pH levels: bicarbonate as a buffer. ^ R.Porter, J.Kaplan, M.Beers ed, Merck Manual Online ^ Spiders: circulatory system. Encyclopedia Britannica online. Retrieved on 2007-11-25. ^ Kienle, Alwin; Lothar Lilge, I. Alex Vitkin, Michael S. Patterson, Brian C. Wilson, Raimund Hibst, and Rudolf Steiner March 1, 1996. Why do veins appear blue? A new look at an old question. Applied Optics 35 7: 1151-60. ^ Austin CC, Perkins SL 2006. Parasites in a biodiversity hotspot: a survey of hematozoa and a molecular phylogenetic analysis of Plasmodium in New Guinea skinks. J. Parasitol. 92 4: 770-7. PMID 16995395. ^ a b c d e Shuster, Carl N 2004. Chapter 11: A blue blood: the circulatory system, in Shuster, Carl N, Jr; Barlow, Robert B; Brockmann, H. Jane: The American Horseshoe Crab. Harvard University Press, pp 276-277. ISBN 0674011597. ^ H. Franklin; Wendell Rosse 1900 2005. 93. Hemolytic Anemias and Acute Blood Loss, in Dennis L. Kasper: Harrison's Principles of Internal Medicine, Anthony S. Fauci, Dan L. Longo, Eugene Braunwald, Stephen L. Hauser, J. Larry Jameson, 16th ion, New York: McGraw-Hill, 607-617. ISBN 0-07-140235-7. ^ Lawlor, Robert 1991. Voices Of The First Day: Awakening in the Aboriginal dreamtime. Page 102-3. Rochester, Vermont: Inner Traditions International, Ltd. ISBN 0-89281-355-5 ^ Law of Anime #40 aka Law of Nasal Sanguination at The Anime Cafe ^ Nostalgia Artwork in blood External links Look up Blood in Wiktionary, the free dictionary. Wikimedia Commons has media related to: Blood v d e Blood General Plasma - Hematopoietic stem cells Lymphoid - WBC T cells: Cytotoxic CD8+, Helper CD4+/Regulatory, γδ, Natural Killer T cell B cells: Plasma, Memory Natural killer cells Lymphokine-activated killer cell Null cell Myeloid - WBC Monocytes/Macrophages Histiocytes, Kupffer cells, Dust cell, Microglia, Osteoclasts, Epithelioid cells, Langhans giant cells, Foreign-body giant cell Granulocytes Neutrophil, Eosinophil, Basophil - Mast cell precursors Dendritic cells Langerhans cells, Follicular dendritic cells Megakaryoblast - Megakaryocyte - Platelets Myeloid - RBC Reticulocyte - Normoblast v d e Cardiovascular system Systemic circulation Heart → Aorta → Arteries → Arterioles → Capillaries → Venules → Veins → Vena cava → Heart Pulmonary circulation Heart → Pulmonary arteries → Lungs → Pulmonary vein → Heart Blood vessels Endothelium - Tunica intima - Tunica media - Tunica externa v d e Transfusion medicine General concepts Apheresis Plasmapheresis, Plateletpheresis, Leukapheresis - Blood transfusion - Coombs test - Cross-matching - Exchange transfusion - International Society of Blood Transfusion - Intraoperative blood salvage - ISBT 128 - Transfusion reactions Human blood group systems - Blood type ABO - Chido-Rodgers - Colton - Cromer - Diego - Dombrock - Duffy - Gerbich - GIL - Hh - Ii - Indian - JMH - Kell Xk - Kidd - Knops - LW - Lewis - Lutheran - MNS - OK - P - Raph - Rh - Scianna - T-Tn - Xg - Yt - Other Blood products Blood donation - Blood substitutes - Cryoprecipitate - Platelets - Plasma - Red blood cells - Whole blood v d e Lymphatic system - The journey of lymph ... Blood → Interstitial fluid → Lymph → Blood... ...Blood → Interstitial fluid → Lymph → Lymph capillary → Afferent lymph vessel Lymph vessel → Lymph node → Efferent lymph vessel Lymph vessel → Lymph trunk Subclavian lymph trunk Jugular lymph trunk Bronchomediastinal lymph trunk Intestinal lymph trunk → Cisterna chyli Lumbar lymph trunk → Cisterna chyli → Lymph duct Right lymphatic duct and Thoracic duct left side → Subclavian vein right and left → Blood... Other concepts Lymphangion Retrieved from http://en..org/wiki/Blood Categories: Blood | Hematology | TissuesHidden categories: All articles with statements | Articles with statements since March 2008 Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Afrikaans العربية Ü?ܪܡÜ?Ü? 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