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14-September-2008 18:02:41 - B2 Bradykinin receptor B2 Identifiers Symbols BDKRB2; B2R; BK-2; BK2; BKR2; BRB2; DKFZp686O088 External IDs OMIM: 113503 MGI: 102845 HomoloGene: 519 Gene ontology Molecular function: rhodopsin-like receptor activity phosphoinositide phospholipase C activity receptor activity bradykinin receptor activity Cellular component: plasma membrane integral to plasma membrane Biological process: smooth muscle contraction inflammatory response transmembrane receptor protein tyrosine kinase signaling pathway G-protein coupled receptor protein signaling pathway elevation of cytosolic calcium ion concentration sensory perception circulation RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 624 12062 Ensembl ENSG00000168398 ENSMUSG00000021070 Uniprot P30411 P32299 Refseq NM_000623 mRNA NP_000614 protein NM_009747 mRNA NP_033877 protein Location Chr 14: 95.74 - 95.78 Mb Chr 12: 105.96 - 105.99 Mb Pubmed search 1 2 Bradykinin receptor B2, also known as BDKRB2, is a bradykinin receptor, but also denotes the human gene encoding it. Contents 1 Mechanism 2 Function 3 Gene 4 See also 5 References 6 Further reading Mechanism The B2 receptor is a G protein-coupled receptor, probably coupled to Gq and Gi. Gq stimulates phospholipase C to increase intracellular free calcium and Gi inhibits adenylate cyclase. Furthermore, the receptor stimulates the mitogen-activated protein kinase pathways. It is ubiquitously and constitutively expressed in healthy tissues. The B2 receptor forms a complex with angiotensin converting enzyme ACE, and this is thought to play a role in cross-talk between the renin-angiotensin system RAS and the kinin-kallikrein system KKS. The heptapeptide angiotensin 1-7 A1-7 also potentiates bradykinin action on B2 receptors.1 Kallidin also signals through the B2 receptor. Function The 9 amino acid bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. Gene Alternate start codons result in two isoforms of the protein.2 See also Bradykinin receptor References ^ Fernandes L, Fortes ZB, Nigro D, Tostes RC, Santos RA, Catelli De Carvalho MH 2001. Potentiation of bradykinin by angiotensin-1-7 on arterioles of spontaneously hypertensive rats studied in vivo. Hypertension 37 2 Part 2: 703-9. PMID 11230360. ^ Entrez Gene: BDKRB2 bradykinin receptor B2. Further reading Duchêne J, Schanstra J, Cellier E, et al. 2002. 30 years: Happy birthday, GPCR. The bradykinin B2 receptor: an alternative and antiproliferative pathway. Néphrologie 23 1: 39-41. PMID 11908480. Ariza AC, Bobadilla NA, Halhali A 2007. Endothelin 1 and angiotensin II in preeeclampsia. Rev. Invest. Clin. 59 1: 48-56. PMID 17569300. Hess JF, Borkowski JA, Young GS, et al. 1992. Cloning and pharmacological characterization of a human bradykinin BK-2 receptor.. Biochem. Biophys. Res. Commun. 184 1: 260-8. PMID 1314587. Eggerickx D, Raspe E, Bertrand D, et al. 1992. Molecular cloning, functional expression and pharmacological characterization of a human bradykinin B2 receptor gene.. Biochem. Biophys. Res. Commun. 187 3: 1306-13. PMID 1329734. Kammerer S, Braun A, Arnold N, Roscher AA 1995. The human bradykinin B2 receptor gene: full length cDNA, genomic organization and identification of the regulatory region.. Biochem. Biophys. Res. Commun. 211 1: 226-33. doi:10.1006/bbrc.1995.1800. PMID 7779089. Braun A, Kammerer S, Böhme E, et al. 1995. Identification of polymorphic sites of the human bradykinin B2 receptor gene.. Biochem. Biophys. Res. Commun. 211 1: 234-40. doi:10.1006/bbrc.1995.1801. PMID 7779090. Ma JX, Wang DZ, Ward DC, et al. 1995. Structure and chromosomal localization of the gene BDKRB2 encoding human bradykinin B2 receptor.. Genomics 23 2: 362-9. doi:10.1006/geno.1994.1512. PMID 7835885. Powell SJ, Slynn G, Thomas C, et al. 1993. Human bradykinin B2 receptor: nucleotide sequence analysis and assignment to chromosome 14.. Genomics 15 2: 435-8. doi:10.1006/geno.1993.1084. PMID 7916737. Menke JG, Borkowski JA, Bierilo KK, et al. 1994. Expression cloning of a human B1 bradykinin receptor.. J. Biol. Chem. 269 34: 21583-6. PMID 8063797. Hess JF, Borkowski JA, Macneil T, et al. 1994. Differential pharmacology of cloned human and mouse B2 bradykinin receptors.. Mol. Pharmacol. 45 1: 1-8. PMID 8302267. McIntyre P, Phillips E, Skidmore E, et al. 1993. Cloned murine bradykinin receptor exhibits a mixed B1 and B2 pharmacological selectivity.. Mol. Pharmacol. 44 2: 346-55. PMID 8394991. AbdAlla S, Godovac-Zimmermann J, Braun A, et al. 1996. Structure of the bradykinin B2 receptors' amino terminus.. Biochemistry 35 23: 7514-9. doi:10.1021/bi9601060. PMID 8652530. Isami S, Kishikawa H, Araki E, et al. 1996. Bradykinin enhances GLUT4 translocation through the increase of insulin receptor tyrosine kinase in primary adipocytes: evidence that bradykinin stimulates the insulin signalling pathway.. Diabetologia 39 4: 412-20. PMID 8777990. Dalemar LR, Ivy Jong YJ, Wilhelm B, Baenziger NL 1996. Protein kinases A and C rapidly modulate expression of human lung fibroblast B2 bradykinin receptor affinity forms.. Eur. J. Cell Biol. 69 3: 236-44. PMID 8900488. Soskic V, Nyakatura E, Roos M, et al. 1999. Correlations in palmitoylation and multiple phosphorylation of rat bradykinin B2 receptor in Chinese hamster ovary cells.. J. Biol. Chem. 274 13: 8539-45. PMID 10085087. Cassano G, Susca F, Lippe C, Guanti G 1999. Two B1 and B2 bradykinin receptor antagonists fail to inhibit the Ca2+ response elicited by bradykinin in human skin fibroblasts.. Gen. Pharmacol. 32 2: 239-44. PMID 10188626. Efremov R, Truong MJ, Darcissac EC, et al. 1999. Human chemokine receptors CCR5, CCR3 and CCR2B share common polarity motif in the first extracellular loop with other human G-protein coupled receptors implications for HIV-1 coreceptor function.. Eur. J. Biochem. 263 3: 746-56. PMID 10469138. Marrero MB, Venema VJ, Ju H, et al. 1999. Endothelial nitric oxide synthase interactions with G-protein-coupled receptors.. Biochem. J. 343 Pt 2: 335-40. PMID 10510297. Reyes-Cruz G, Vázquez-Prado J, Müller-Esterl W, Vaca L 2000. Regulation of the human bradykinin B2 receptor expressed in sf21 insect cells: a possible role for tyrosine kinases.. J. Cell. Biochem. 76 4: 658-73. PMID 10653985. Golser R, Gorren AC, Leber A, et al. 2000. Interaction of endothelial and neuronal nitric-oxide synthases with the bradykinin B2 receptor. Binding of an inhibitory peptide to the oxygenase domain blocks uncoupled NADPH oxidation.. J. Biol. Chem. 275 8: 5291-6. PMID 10681501. This article incorporates text from the United States National Library of Medicine, which is in the public domain. This transmembrane receptor-related article is a stub. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened v d e Neuropeptide receptors Hypothalamic hormone receptors CRH - FSH - LHRH - TRH - Somatostatin Pituitary hormone receptors Vasopressin 1A, 1B, 2 - Oxytocin - LHCG - Type I cytokine receptor GH, Prolactin - TSH Other hormone receptors Atrial natriuretic factor - Calcitonin - Cholecystokinin A, B - VIP Opioid receptors Delta - Kappa - Mu - Sigma 1, 2 - Nociceptin Other neuropeptide receptors Angiotensin - Bradykinin B1, B2 / Tachykinin TACR1 - Calcitonin gene-related peptide - Galanin - GPCR neuropeptide B/W, FF, S, Y - Neurotensin Retrieved from http://en..org/wiki/Bradykinin_receptor_B2 Categories: Genes on chromosome 14 | Human proteins | Transmembrane receptor stubs | Cell signaling | Signal transduction | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 07:32
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