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14-September-2008 18:02:35 - Neuroimaging Redirected from Brain imaging Para-sagittal MRI of the head in a patient with benign familial macrocephaly. Para-sagittal MRI of the head in a patient with benign familial macrocephaly. Neuroimaging includes the use of various techniques to either directly or indirectly image the structure, function/pharmacology of the brain. It is a relatively new discipline within medicine and neuroscience/psychology. Contents 1 Overview 2 History 3 Brain imaging techniques 3.1 Computed Axial Tomography 3.2 Diffuse Optical Imaging 3.3 Event Related Optical Signal 3.4 Magnetic Resonance Imaging 3.5 Functional Magnetic Resonance Imaging 3.6 MagnetoEncephaloGraphy 3.7 Positron Emission Tomography 3.8 Single Photon Emission Computed Tomography 4 See also 5 References 6 Further reading 7 External links Overview Neuroimaging falls into two broad categories: Structural imaging, which deals with the structure of the brain and the diagnosis of gross large scale intracranial disease such as tumor, and injury, and functional imaging, which is used to diagnose metabolic diseases and lesions on a finer scale such as Alzheimer's disease and also for neurological and cognitive psychology research and building brain-computer interfaces. Functional imaging enables, for example, the processing of information by centers in the brain to be visualized directly. Such processing causes the involved area of the brain to increase metabolism and light up on the scan. History Main article: History of neuroimaging In 1918 the American neurosurgeon Walter Dandy introduced the technique of ventriculography. X-ray images of the ventricular system within the brain were obtained by injection of filtered air directly into one or both lateral ventricles of the brain. Dandy also observed that air introduced into the subarachnoid space via lumbar spinal puncture could enter the cerebral ventricles and also demonstrate the cerebrospinal fluid compartments around the base of the brain and over its surface. This technique was called pneumoencephalography. In 1927 Egas Moniz, professor of neurology in Lisbon, introduced cerebral angiography, whereby both normal and abnormal blood vessels in and around the brain could be visualized with great accuracy. In the early 1970s, Allan McLeod Cormack and Godfrey Newbold Hounsfield introduced computerized axial tomography CAT or CT scanning, and ever more detailed anatomic images of the brain became available for diagnostic and research purposes. Cormack and Hounsfield won the 1979 Nobel Prize for Physiology or Medicine for their work. Soon after the introduction of CAT in the early 1980s, the development of radioligands allowed single photon emission computed tomography SPECT and positron emission tomography PET of the brain. More or less concurrently, magnetic resonance imaging MRI or MR scanning was developed by researchers including Peter Mansfield and Paul Lauterbur, who were awarded the Nobel Prize for Physiology or Medicine in 2003. In the early 1980s MRI was introduced clinically, and during the 1980s a veritable explosion of technical refinements and diagnostic MR applications took place. Scientists soon learned that the large blood flow changes measured by PET could also be imaged by the correct type of MRI. Functional magnetic resonance imaging fMRI was born, and since the 1990s, fMRI has come to dominate the brain mapping field due to its low invasiveness, lack of radiation exposure, and relatively wide availability. As noted above fMRI is also beginning to dominate the field of stroke treatment. In early 2000s the field of neuroimaging reached the stage where limited practical applications of functional brain imaging have become feasible. The main application area is crude forms of brain-computer interface. Brain imaging techniques Computed Axial Tomography Computed Tomography CT or Computed Axial Tomography CAT scanning uses a series of x-rays of the head taken from many different directions. Typically used for quickly viewing brain injuries, CT scanning uses a computer program that performs a numerical integral calculation the inverse Radon transform on the measured x-ray series to estimate how much of an x-ray beam is absorbed in a small volume of the brain. Typically the information is presented as cross sections of the brain.1 In approximation, the more dense a material is, the whiter a volume of it will appear on the scan just as in the more familiar flat X-rays. CT scans are primarily used for evaluating swelling from tissue damage in the brain and in assessment of ventricle size. Modern CT scanning can provide reasonably good images in a matter of minutes. Diffuse Optical Imaging Diffuse Optical Imaging DOI or Diffuse Optical Tomography DOT is a medical imaging modality which uses near infrared light to generate images of the body. The technique measures the optical absorption of haemoglobin, and relies on the absorption spectrum of haemoglobin varying with its oxygenation status. Event Related Optical Signal Event Related Optical Signal EROS is a brain-scanning technique which uses infrared light through optical fibers to measure changes in optical properties of active areas of the cerebral cortex. Whereas techniques such as diffuse optical imaging DOT and near infrared spectroscopy NIRS measure optical absorption of haemoglobin, and thus are based on blood flow, EROS takes advantage of the scattering properties of the neurons themselves, and thus provide a much more direct measure of cellular activity. EROS can pinpoint activity in the brain within millimeters spatially and within milliseconds temporally. Its biggest downside is the inability to detect activity more than a few centimeters deep. EROS is a new, relatively inexpensive technique that is non-invasive to the test subject. It was developed at the University of Illinois at Urbana-Champaign where it is now used in the Cognitive Neuroimaging Laboratory of Dr. Gabriele Gratton and Dr. Monica Fabiani. Magnetic Resonance Imaging Sagittal MRI slice at the midline. Sagittal MRI slice at the midline. Magnetic Resonance Imaging MRI uses magnetic fields and radio waves to produce high quality two- or three-dimensional images of brain structures without use of ionizing radiation X-rays or radioactive tracers. During an MRI, a large cylindrical magnet creates a magnetic field around the head of the patient through which radio waves are sent. When the magnetic field is imposed, each point in space has a unique radio frequency at which the signal is received and transmitted Preuss. Sensors read the frequencies and a computer uses the information to construct an image. The detection mechanisms are so precise that changes in structures over time can be detected. Using MRI, scientists can create images of both surface and subsurface structures with a high degree of anatomical detail. MRI scans can produce cross sectional images in any direction from top to bottom, side to side, or front to back. The problem with original MRI technology was that while it provides a detailed assessment of the physical appearance, water content, and many kinds of subtle derangements of structure of the brain such as inflammation or bleeding, it fails to provide information about the metabolism of the brain i.e. how actively it is functioning at the time of imaging. A distinction is therefore made between MRI imaging and functional MRI imaging fMRI, where MRI provides only structural information on the brain while fMRI yields both structural and functional data. Functional Magnetic Resonance Imaging Axial MRI slice at the level of the basal ganglia, showing fMRI BOLD signal changes overlayed in red increase and blue decrease tones. Axial MRI slice at the level of the basal ganglia, showing fMRI BOLD signal changes overlayed in red increase and blue decrease tones. Functional Magnetic Resonance Imaging fMRI relies on the paramagnetic properties of oxygenated and deoxygenated hemoglobin to see images of changing blood flow in the brain associated with neural activity. This allows images to be generated that reflect which brain structures are activated and how during performance of different tasks. Most fMRI scanners allow subjects to be presented with different visual images, sounds and touch stimuli, and to make different actions such as pressing a button or moving a joystick. Consequently, fMRI can be used to reveal brain structures and processes associated with perception, thought and action. The resolution of fMRI is about 2-3 millimeters at present, limited by the spatial spread of the hemodynamic response to neural activity. It has largely superseded PET for the study of brain activation patterns. PET, however, retains the significant advantage of being able to identify specific brain receptors or transporters associated with particular neurotransmitters through its ability to image radiolabelled receptor ligands receptor ligands are any chemicals that stick to receptors. As well as research on healthy subjects, fMRI is increasingly used for the medical diagnosis of disease. Because fMRI is exquisitely sensitive to blood flow, it is extremely sensitive to early changes in the brain resulting from ischemia abnormally low blood flow, such as the changes which follow stroke. Early diagnosis of certain types of stroke is increasingly important in neurology, since substances which dissolve blood clots may be used in the first few hours after certain types of stroke occur, but are dangerous to use afterwards. Brain changes seen on fMRI may help to make the decision to treat with these agents. With between 72% and 90% accuracy where chance would achieve 0.8%,2 fMRI techniques can decide which of a set of known images the subject is viewing.3 MagnetoEncephaloGraphy Magnetoencephalography MEG is an imaging technique used to measure the magnetic fields produced by electrical activity in the brain via extremely sensitive devices such as superconducting quantum interference devices SQUIDs. MEG offers a very direct measurement neural electrical activity compared to fMRI for example with very high temporal resolution but relatively low spatial resolution. The advantage of measuring the magnetic fields produced by neural activity is that they are not distorted by surrounding tissue, unlike the electric fields measured by EEG particularly the skull and scalp. There are many uses for the MEG, including assisting surgeons in localizing a pathology, assisting researchers in determining the function of various parts of the brain, neurofeedback, and others. Positron Emission Tomography PET scan of a normal 20-year-old brain. PET scan of a normal 20-year-old brain. Positron Emission Tomography PET measures emissions from radioactively labeled metabolically active chemicals that have been injected into the bloodstream. The emission data are computer-processed to produce 2- or 3-dimensional images of the distribution of the chemicals throughout the brain Nilsson 57. The positron emitting radioisotopes used are produced by a cyclotron, and chemicals are labelled with these radioactive atoms. The labeled compound, called a radiotracer, is injected into the bloodstream and eventually makes its way to the brain. Sensors in the PET scanner detect the radioactivity as the compound accumulates in various regions of the brain. A computer uses the data gathered by the sensors to create multicolored 2- or 3-dimensional images that show where the compound acts in the brain. Especially useful are a wide array of ligands used to map different aspects of neurotransmitter activity, with by far the most commonly used PET tracer being a labeled form of glucose see FDG. The greatest benefit of PET scanning is that different compounds can show blood flow and oxygen and glucose metabolism in the tissues of the working brain. These measurements reflect the amount of brain activity in the various regions of the brain and allow us to learn more about how the brain works. PET scans were superior to all other metabolic imaging methods in terms of resolution and speed of completion as little as 30 seconds, when they first became available. The improved resolution permitted better study to be made as to the area of the brain activated by a particular task. The biggest drawback of PET scanning is that because the radioactivity decays rapidly, it is limited to monitoring short tasks Nilsson 60. Before fMRI technology came online, PET scanning was the preferred method of functional as opposed to structural brain imaging, and it still continues to make large contributions to neuroscience. PET scanning is also used for diagnosis of brain disease, most notably because brain tumors, strokes, and neuron-damaging diseases which cause dementia such as Alzheimer's disease all cause great changes in brain metabolism, which in turn causes easily detectable changes in PET scans. PET is probably most useful in early cases of certain dementias with classic examples being Azheimer's disease and Pick's disease where the early damage is too diffuse and makes too little difference in brain volume and gross structure to change CT and standard MRI images enough to be able to reliably differentiate it from the normal range of cortical atrophy which occurs with aging in many but not all persons, and which does not cause clinical dementia. Single Photon Emission Computed Tomography Single Photon Emission Computed Tomography SPECT is similar to PET and uses gamma ray emitting radioisotopes and a gamma camera to record data that a computer uses to construct two- or three-dimensional images of active brain regions Ball. SPECT relies on an injection of radioactive tracer, which is rapidly taken up by the brain but does not redistribute. Uptake of SPECT agent is nearly 100% complete within 30 - 60s, reflecting cerebral blood flow CBF at the time of injection. These properties of SPECT make it particularly well suited for epilepsy imaging, which is usually made difficult by problems with patient movement and variable seizure types. SPECT provides a snapshot of cerebral blood flow since scans can be acquired after seizure termination so long as the radioactive tracer was injected at the time of the seizure. A significant limitation of SPECT is its poor resolution about 1 cm compared to that of MRI. Like PET, SPECT also can be used to differentiate different kinds of disease process which produce dementia, and it is increasingly used for this purpose. Neuro-PET has a disadvantage of requiring use of a tracers with half-lives of at most 110 minutes, such as FDG. These must be made in a cyclotron, and are expensive or even unavailable if necessary transport times are prolonged more than a few half-lives. SPECT, however, is able to make use of tracers with much longer half-lives, such as technetium-99m, and as a result, is far more widely available. See also Brain mapping Functional neuroimaging functional near-infrared imaging History of brain imaging Human Cognome Project Magnetic resonance imaging Magnetoencephalography Medical imaging Neuroimaging software Statistical parametric mapping Transcranial magnetic stimulation Voxel-based morphometry References ^ Jeeves, p. 21 ^ Smith, Kerri March 5, 2008. Mind-reading with a brain scan, Nature News, Nature Publishing Group. Retrieved on 2008-03-05. ^ Keim, Brandon March 5, 2008. Brain Scanner Can Tell What You're Looking At, Wired News, CondéNet. Retrieved on 2008-03-05. Further reading Philip Ball. Brain Imaging Explained. J. Graham Beaumont 1983. Introduction to Neuropsychology. New York: The Guilford Press. Jean-Pierre Changeux 1985. Neuronal Man: The Biology of Mind. New York: Oxford University Press. Malcom Jeeves 1994. Mind Fields: Reflections on the Science of Mind and Brain. Grand Rapids, MI: Baker Books. Richard G. Lister and Herbert J. Weingartner 1991. Perspectives on Cognitive Neuroscience. New York: Oxford University Press. James Mattson and Merrill Simon 1996. The Pioneers of NMR and Magnetic Resonance in Medicine. United States: Dean Books Company. Lars-Goran Nilsson and Hans J. Markowitsch 1999. Cognitive Neuroscience of Memory. Seattle: Hogrefe Huber Publishers. Donald A. Norman 1981. Perspectives on Cognitive Science. New Jersey: Ablex Publishing Corporation. Brenda Rapp 2001. The Handbook of Cognitive Neuropsychology. Ann Arbor, MI: Psychology Press. External links The Whole Brain Atlas @ Harvard The McConnell Brain Imaging Center, McGill University The American Society of Neuroimaging ASN. UCLA Neuroimaging Training Program. Laboratory of Neuro Imaging at UCLA A Neuroimaging portal BrainMapping.org, a free BrainMapping community information portal Lecture notes on mathematical aspects of neuroimaging by Will Penny, University College London Transcranial Magnetic Stimulation. by Michael Leventon in association with MIT AI Lab. Foundations of fMRI by Jamie Shorey. v d e Medicine Psychiatry Subspecialties Behavioral medicine Biological psychiatry Child and adolescent psychiatry Cross-cultural psychiatry Emergency psychiatry Forensic psychiatry Geriatric psychiatry Liaison psychiatry Military psychiatry Neuropsychiatry Social psychiatry Societies American Board of Psychiatry and Neurology American Psychiatric Association Royal College of Psychiatrists Related topics Neuroimaging Neurophysiology Psychiatrist Psychopharmacology Psychosurgery Psychotherapy Lists List of psychiatrists List of figures in psychiatry List of physicians List of psychiatric medications List of psychiatric medications by condition treated List of neurological disorders List of psychotherapies List of counseling topics v d e Neuroscience Behavioral neurology · Cognitive neuroscience · Computational neuroscience · Molecular cellular cognition · Neural engineering · Neuroanatomy · Neurobiology · Neurochemistry · Neuroendocrinology · Neuroimaging · Neurolinguistics · Neurology · Neuromonitoring · Neuropharmacology · Neurophysiology · Neuropsychiatry · Neuropsychology · Neurosurgery · Systems neuroscience v d e Visualization Fields Creative visualization · Chemical imaging · Crime mapping · Data visualization · Educational visualization · Flow visualization · Geovisualization · Information visualization · Medical imaging · Music visualization · Product visualization · Scientific visualization · Software visualization · Volume visualization Image types Chart · Computer graphics · Diagram · Graph of a function · Ideogram · Illustration · Information graphics · Map · Photograph · Pictogram · Statistical graphics · Table · Technical drawing Experts Jacques Bertin · Stuart Card · Thomas A. DeFanti · Michael Friendly · Nigel Holmes · Jock D. Mackinlay · Michael Maltz · Bruce H. McCormick · Charles Joseph Minard · Otto Neurath · William Playfair · Clifford A. Pickover · Arthur H. Robinson · Lawrence J. Rosenblum · Adolphe Quetelet · George G. Robertson · Ben Shneiderman · Edward Tufte Related topics Cartography · Computer graphics · Graph drawing · Graphic design · Imaging science · Information science · Mental visualisation · Neuroimaging · Spatial analysis · Visual analytics · Visual communication · Visual perception Retrieved from http://en..org/wiki/Neuroimaging Categories: Radiology | Neuroimaging Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages বাংলা Français Ã?slenska עברית 日本語 РуÑ?Ñ?кий Svenska ä¸æ–‡ This page was last modified on 9 September 2008, at 16:45
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