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14-September-2008 18:02:49 - Bronchial hyperresponsiveness Bronchial hyperresponsiveness or other combinations with airway or hyperreactivity is a state characterised by easily triggered bronchospasm contraction of the bronchioles or small airways. Bronchial hyperresponsiveness can be assessed with a bronchial challenge test. This most often uses products like metacholine or histamine. These chemicals trigger bronchospasm in normal individuals as well, but people with bronchial hyperresponsiveness have a lower threshold. Bronchial hyperresponsiveness is a hallmark of asthma but also occurs frequently in people suffering from chronic obstructive pulmonary disease COPD.1 In the Lung Heart Study, bronchial hyperresponsiveness was present in approximately two-thirds of patients with non-severe COPD, and this predicted lung function decline independently of other factors.2 In asthma it tends to be reversible with bronchodilator therapy, while this is not the case in COPD. Footnotes ^ Postma DS, Kerstjens HA November 1998. Characteristics of airway hyperresponsiveness in asthma and chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 158 5 Pt 3: S187-92. PMID 9817744. ^ Tashkin DP, Altose MD, Connett JE, Kanner RE, Lee WW, Wise RA June 1996. Methacholine reactivity predicts changes in lung function over time in smokers with early chronic obstructive pulmonary disease. The Lung Health Study Research Group. Am. J. Respir. Crit. Care Med. 153 6 Pt 1: 1802-11. PMID 8665038. v d e Respiratory system, physiology: respiratory physiology Volumes lung volumes - vital capacity - functional residual capacity - respiratory minute volume - closing capacity - dead space - spirometry - body plethysmography - peak flow meter - thoracic independent volume Airways ventilation V positive pressure - breath inhalation, exhalation -respiratory rate - respirometer - pulmonary surfactant - compliance - hysteresivity - airway resistance - bronchial hyperresponsiveness - bronchial challenge test Blood pulmonary circulation - perfusion Q - hypoxic pulmonary vasoconstriction - pulmonary shunt Interactions ventilation/perfusion ratio V/Q and scan - zones of the lung - gas exchange - pulmonary gas pressures - alveolar gas equation - alveolar-arterial gradient - hemoglobin - oxygen-haemoglobin dissociation curve 2,3-DPG, Bohr effect, Haldane effect - carbonic anhydrase chloride shift - oxyhemoglobin - respiratory quotient - arterial blood gas - diffusion capacity - Dlco Control of respiration pons pneumotaxic center, apneustic center - medulla dorsal respiratory group, ventral respiratory group - chemoreceptors central, peripheral - pulmonary stretch receptors Hering-Breuer reflex Insufficiency high altitude - oxygen toxicity - hypoxia Retrieved from http://en..org/wiki/Bronchial_hyperresponsiveness Categories: Respiratory therapy | Pulmonology Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 21 July 2008, at 18:3

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