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14-September-2008 18:02:41 - C5a receptor Complement component 5a receptor 1 Identifiers Symbols C5AR1; C5A; C5AR; C5R1; CD88 External IDs OMIM: 113995 MGI: 88232 HomoloGene: 20413 Gene ontology Molecular function: rhodopsin-like receptor activity receptor activity C5a anaphylatoxin receptor activity Cellular component: plasma membrane integral to plasma membrane Biological process: activation of MAPK activity chemotaxis immune response cellular defense response signal transduction G-protein coupled receptor protein signaling pathway phospholipase C activation elevation of cytosolic calcium ion concentration sensory perception of chemical stimulus RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 728 12273 Ensembl ENSG00000197405 ENSMUSG00000049130 Uniprot P21730 Q3TZ86 Refseq NM_001736 mRNA NP_001727 protein NM_007577 mRNA NP_031603 protein Location Chr 19: 52.5 - 52.52 Mb Chr 7: 15.41 - 15.42 Mb Pubmed search 1 2 The C5a receptor also known as complement component 5a receptor 1 C5AR1 or CD88 Cluster of Differentiation 88 is a G protein-coupled receptor for C5a. It functions as a complement receptor.1 C5a receptor structure and its residues possessing role in ligand binding or signaling. C5a receptor structure and its residues possessing role in ligand binding or signaling. Contents 1 Cells 2 See also 3 References 4 Further reading 5 External links Cells The C5a receptor is expressed on:2 Granulocytes Monocytes Dendritic cells Hepatoma-derived cell line HepG2 Astrocytes Microglia See also Complement component 5a for binding mechanism References ^ Gerard C, Gerard NP 1994. C5A anaphylatoxin and its seven transmembrane-segment receptor. Annu. Rev. Immunol. 12: 775-808. doi:10.1146/annurev.iy.12.040194.004015. PMID 8011297. ^ Unless else specified in list, then ref is:PROW and IWHLDA: CD88 Further reading Sengeløv H 1996. Complement receptors in neutrophils.. Crit. Rev. Immunol. 15 2: 107-31. PMID 8573284. Beil WJ, Schulz M, Wefelmeyer U 2001. Mast cell granule composition and tissue location--a close correlation.. Histol. Histopathol. 15 3: 937-46. PMID 10963136. Yamamoto T 2007. Roles of the ribosomal protein S19 dimer and the C5a receptor in pathophysiological functions of phagocytic leukocytes.. Pathol. Int. 57 1: 1-11. doi:10.1111/j.1440-1827.2007.02049.x. PMID 17199736. Bao L, Gerard NP, Eddy RL, et al. 1992. Mapping of genes for the human C5a receptor C5AR, human FMLP receptor FPR, and two FMLP receptor homologue orphan receptors FPRH1, FPRH2 to chromosome 19.. Genomics 13 2: 437-40. PMID 1612600. Gerard NP, Gerard C 1991. The chemotactic receptor for human C5a anaphylatoxin.. Nature 349 6310: 614-7. doi:10.1038/349614a0. PMID 1847994. Boulay F, Mery L, Tardif M, et al. 1991. Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells.. Biochemistry 30 12: 2993-9. PMID 2007135. Wahl SM, Allen JB, Gartner S, et al. 1989. HIV-1 and its envelope glycoprotein down-regulate chemotactic ligand receptors and chemotactic function of peripheral blood monocytes.. J. Immunol. 142 10: 3553-9. PMID 2541200. Foreman KE, Vaporciyan AA, Bonish BK, et al. 1994. C5a-induced expression of P-selectin in endothelial cells.. J. Clin. Invest. 94 3: 1147-55. PMID 7521884. Giannini E, Brouchon L, Boulay F 1995. Identification of the major phosphorylation sites in human C5a anaphylatoxin receptor in vivo.. J. Biol. Chem. 270 32: 19166-72. PMID 7642584. Buhl AM, Osawa S, Johnson GL 1995. Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor.. J. Biol. Chem. 270 34: 19828-32. PMID 7649993. Wennogle LP, Conder L, Winter C, et al. 1994. Stabilization of C5a receptor--G-protein interactions through ligand binding.. J. Cell. Biochem. 55 3: 380-8. doi:10.1002/jcb.240550316. PMID 7962171. Gerard NP, Bao L, Xiao-Ping H, et al. 1993. Human chemotaxis receptor genes cluster at 19q13.3-13.4. Characterization of the human C5a receptor gene.. Biochemistry 32 5: 1243-50. PMID 8383526. Ames RS, Li Y, Sarau HM, et al. 1996. Molecular cloning and characterization of the human anaphylatoxin C3a receptor.. J. Biol. Chem. 271 34: 20231-4. PMID 8702752. Werfel T, Zwirner J, Oppermann M, et al. 1996. CD88 antibodies specifically bind to C5aR on dermal CD117+ and CD14+ cells and react with a desmosomal antigen in human skin.. J. Immunol. 157 4: 1729-35. PMID 8759762. Höpken UE, Lu B, Gerard NP, Gerard C 1996. The C5a chemoattractant receptor mediates mucosal defence to infection.. Nature 383 6595: 86-9. doi:10.1038/383086a0. PMID 8779720. Chen Z, Zhang X, Gonnella NC, et al. 1998. Residues 21-30 within the extracellular N-terminal region of the C5a receptor represent a binding domain for the C5a anaphylatoxin.. J. Biol. Chem. 273 17: 10411-9. PMID 9553099. Floreani AA, Heires AJ, Welniak LA, et al. 1998. Expression of receptors for C5a anaphylatoxin CD88 on human bronchial epithelial cells: enhancement of C5a-mediated release of IL-8 upon exposure to cigarette smoke.. J. Immunol. 160 10: 5073-81. PMID 9590258. Ottonello L, Corcione A, Tortolina G, et al. 1999. rC5a directs the in vitro migration of human memory and naive tonsillar B lymphocytes: implications for B cell trafficking in secondary lymphoid tissues.. J. Immunol. 162 11: 6510-7. PMID 10352266. Kohleisen B, Shumay E, Sutter G, et al. 2000. Stable expression of HIV-1 Nef induces changes in growth properties and activation state of human astrocytes.. AIDS 13 17: 2331-41. PMID 10597774. Monk PN, Scola A-M, Madala P, Fairlie DP 2007. Function, structure and therapeutic potential of complement C5a receptors. British Journal of Pharmacology 152: 429-48. PMID 17603557. External links IUPHAR GPCR Database - C5a receptor MeSH C5a+receptors This membrane protein-related article is a stub. v d e Proteins: clusters of differentiation see also list of human clusters of differentiation 1-50 CD1 a-c, 1A, 1D, 1E - CD2 - CD3 γ, δ, ε - CD4 - CD5 - CD6 - CD7 - CD8 a - CD9 - CD10 - CD11 a, b, c - CD13 - CD14 - CD15 - CD16 A, B - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 A, B - CD33 - CD34 - CD35 - CD36 - CD37 - CD38 - CD39 - CD40 - CD41- CD42 a, b, c, d - CD43 - CD44 - CD45 - CD46 - CD47 - CD48 - CD49 a, b, c, d, e, f - CD50 51-100 CD51 - CD52 - CD53 - CD54 - CD55 - CD56 - CD57- CD58 - CD59 - CD61 - CD62 E, L, P - CD63 - CD64 - CD66 a, b, c, d, e, f - CD68 - CD69 - CD70 - CD71 - CD72 - CD73 - CD74 - CD79 a, b - CD80 - CD81 - CD82 - CD83 - CD84 - CD85 a, d, e, h, j, k - CD86 - CD87 - CD88 - CD89 - CD90 - CD91- CD92 - CD93 - CD94 - CD95 - CD97 - CD98 - CD99 - CD100 101-150 CD101 - CD102 - CD103 - CD104 - CD105 - CD106 - CD107 a, b - CD108 - CD109 - CD110 - CD111 - CD112 - CD113 - CD114 - CD115 - CD116 - CD117 - CD118 - CD119 - CD120 a, b - CD121 a, b - CD122 - CD123 - CD124 - CD125 - CD126 - CD127 - CD129 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD136 - CD137 - CD138 - CD140b - CD141 - CD142 - CD143 - CD144 - CD146 - CD147 - CD148 - CD150 151-200 CD151 - CD152 - CD153 - CD154 - CD155 - CD156 a, b, c - CD157 - CD158 a, d, e, i, k - CD159 a, c - CD160 - CD161 - CD162 - CD163 - CD164 - CD166 - CD167 a, b - CD168 - CD169 - CD170 - CD171 - CD172 a, b, g - CD174 - CD177 - CD178 - CD179 a, b - CD181 - CD182 - CD183 - CD184 - CD185 - CD186 - CD191 - CD192 - CD193 - CD194 - CD195 - CD196 - CD197 - CDw198 - CDw199 - CD200 201-250 CD201 - CD202b - CD204 - CD205 - CD206 - CD207 - CD208 - CD209 - CDw210 a, b - CD212 - CD213a 1, 2 - CD217 - CD218 a, b - CD220 - CD221 - CD222 - CD223 - CD224 - CD225 - CD226 - CD227 - CD228 - CD229 - CD230 - CD233 - CD234 - CD235 a, b - CD236 - CD238 - CD239 - CD240CE - CD241 - CD243 - CD244 - CD246 - CD247- CD248 - CD249 251-300 CD252 - CD253 - CD254 - CD256 - CD257 - CD258 - CD261 - CD262 - CD264 - CD265 - CD266 - CD267 - CD268 - CD269 - CD271 - CD272 - CD273 - CD274 - CD275 - CD276 - CD278 - CD279 - CD280 - CD281 - CD282 - CD283 - CD284 - CD286 - CD288 - CD289 - CD290 - CD292 - CDw293 - CD294 - CD295 - CD297 - CD298 - CD299 301-350 CD300A - CD304 - CD305 - CD307 - CD309 - CD312 - CD314 - CD315 - CD316 - CD317 - CD318 - CD320 - CD321 - CD322 - CD324 - CD325 - CD326 - CD328 - CD329 - CD331 - CD332 - CD333 - CD334 - CD335 - CD336 - CD337 - CD338 - CD339 - CD340 - CD344 - CD349 - CD350 v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened v d e Proteins: complement system C, L, A Activators CLA: C3-convertase - C5-convertase - MAC C6, C7, C8, C9 - L: Mannan-binding lectin - A: Factor P/Properdin Enzymes C: C1Q/C1R/C1S - C4 C4a - C2 - CLA: C3 C3a, C3b/iC3b - C5 C5a - L: MASP1 - MASP2 - A: Complement factor B - Factor D Inhibitors CLA: C1-inhibitor - Decay accelerating factor - Factor I - CL: C4BP - A: Factor H Complement receptors CR1 - CR2 - CR3 - CR4 - CD11b/CD11c/CD18 - Anaphylatoxin C3a, C5a Retrieved from http://en..org/wiki/C5a_receptor Categories: Genes on chromosome 19 | Human proteins | Membrane protein stubsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 04:31
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