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14-September-2008 18:02:41 - CELSR3 Cadherin, EGF LAG seven-pass G-type receptor 3 flamingo homolog, Drosophila Identifiers Symbols CELSR3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2; RESDA1 External IDs OMIM: 604264 MGI: 1858236 HomoloGene: 1077 Gene ontology Molecular function: receptor activity G-protein coupled receptor activity calcium ion binding Cellular component: membrane integral to membrane Biological process: homophilic cell adhesion signal transduction neuropeptide signaling pathway multicellular organismal development Orthologs Human Mouse Entrez 1951 107934 Ensembl n/a ENSMUSG00000023473 Uniprot n/a Q6ZQ40 Refseq NM_001407 mRNA NP_001398 protein NM_080437 mRNA NP_536685 protein Location n/a Chr 9: 108.68 - 108.71 Mb Pubmed search 1 2 Cadherin, EGF LAG seven-pass G-type receptor 3 flamingo homolog, Drosophila, also known as CELSR3, is a human gene.1 The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.1 See also Flamingo protein References ^ a b Entrez Gene: CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 flamingo homolog, Drosophila. Further reading Bonaldo MF, Lennon G, Soares MB 1997. Normalization and subtraction: two approaches to facilitate gene discovery.. Genome Res. 6 9: 791-806. PMID 8889548. Nakayama M, Nakajima D, Nagase T, et al. 1998. Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.. Genomics 51 1: 27-34. doi:10.1006/geno.1998.5341. PMID 9693030. Wu Q, Maniatis T 1999. A striking organization of a large family of human neural cadherin-like cell adhesion genes.. Cell 97 6: 779-90. PMID 10380929. Wu Q, Maniatis T 2000. Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.. Proc. Natl. Acad. Sci. U.S.A. 97 7: 3124-9. doi:10.1073/pnas.060027397. PMID 10716726. Formstone CJ, Barclay J, Rees M, Little PF 2000. Chromosomal localization of Celsr2 and Celsr3 in the mouse; Celsr3 is a candidate for the tippy tip lethal mutant on chromosome 9.. Mamm. Genome 11 5: 392-4. PMID 10790539. Nakayama M, Kikuno R, Ohara O 2003. Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.. Genome Res. 12 11: 1773-84. doi:10.1101/gr.406902. PMID 12421765. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. 2005. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.. Genomics 84 1: 23-33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201. This transmembrane receptor-related article is a stub. This article incorporates text from the United States National Library of Medicine, which is in the public domain. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/CELSR3 Categories: Human proteins | Transmembrane receptor stubs | Adhesion GPCRs | G protein coupled receptorsHidden category: Protein pages needing a picture
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