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14-September-2008 18:02:41 - Calcitonin receptor Calcitonin receptor Identifiers Symbols CALCR; CRT; CTR; CTR1 External IDs OMIM: 114131 MGI: 101950 HomoloGene: 1320 Gene ontology Molecular function: phosphoinositide phospholipase C activity receptor activity G-protein coupled receptor activity calcitonin receptor activity Cellular component: plasma membrane integral to plasma membrane Biological process: ossification signal transduction G-protein coupled receptor protein signaling pathway adenylate cyclase activation phospholipase C activation RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 799 12311 Ensembl ENSG00000004948 ENSMUSG00000023964 Uniprot P30988 Q790U4 Refseq NM_001742 mRNA NP_001733 protein NM_001042725 mRNA NP_001036190 protein Location Chr 7: 92.89 - 93.04 Mb Chr 6: 3.64 - 3.67 Mb Pubmed search 1 2 The calcitonin receptor is a G protein-coupled receptor which binds the peptide hormone calcitonin and is involved in maintenance of calcium homeostasis.1 It works by activating the G-proteins Gs and Gq2 References ^ Purdue BW, Tilakaratne N, Sexton PM 2002. Molecular pharmacology of the calcitonin receptor. Recept. Channels 8 3-4: 243-55. PMID 12529940. ^ senselab Further reading Pondel M 2001. Calcitonin and calcitonin receptors: bone and beyond.. International journal of experimental pathology 81 6: 405-22. PMID 11298188. Gorn AH, Lin HY, Yamin M, et al. 1992. Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line.. J. Clin. Invest. 90 5: 1726-35. PMID 1331173. Albrandt K, Brady EM, Moore CX, et al. 1995. Molecular cloning and functional expression of a third isoform of the human calcitonin receptor and partial characterization of the calcitonin receptor gene.. Endocrinology 136 12: 5377-84. PMID 7588285. Egerton M, Needham M, Evans S, et al. 1995. Identification of multiple human calcitonin receptor isoforms: heterologous expression and pharmacological characterization.. J. Mol. Endocrinol. 14 2: 179-89. PMID 7619207. Nussenzveig DR, Mathew S, Gershengorn MC 1995. Alternative splicing of a 48-nucleotide exon generates two isoforms of the human calcitonin receptor.. Endocrinology 136 5: 2047-51. PMID 7720653. Nakamura M, Hashimoto T, Nakajima T, et al. 1995. A new type of human calcitonin receptor isoform generated by alternative splicing.. Biochem. Biophys. Res. Commun. 209 2: 744-51. PMID 7733946. Pérez Jurado LA, Li X, Francke U 1995. The human calcitonin receptor gene CALCR at 7q21.3 is outside the deletion associated with the Williams syndrome.. Cytogenet. Cell Genet. 70 3-4: 246-9. PMID 7789182. Nussenzveig DR, Thaw CN, Gershengorn MC 1994. Inhibition of inositol phosphate second messenger formation by intracellular loop one of a human calcitonin receptor. Expression and mutational analysis of synthetic receptor genes.. J. Biol. Chem. 269 45: 28123-9. PMID 7961748. Kuestner RE, Elrod RD, Grant FJ, et al. 1994. Cloning and characterization of an abundant subtype of the human calcitonin receptor.. Mol. Pharmacol. 46 2: 246-55. PMID 8078488. Frendo JL, Pichaud F, Mourroux RD, et al. 1994. An isoform of the human calcitonin receptor is expressed in TT cells and in medullary carcinoma of the thyroid.. FEBS Lett. 342 2: 214-6. PMID 8143880. Masi L, Becherini L, Gennari L, et al. 1998. Allelic variants of human calcitonin receptor: distribution and association with bone mass in postmenopausal Italian women.. Biochem. Biophys. Res. Commun. 245 2: 622-6. doi:10.1006/bbrc.1998.8445. PMID 9571205. Taboulet J, Frenkian M, Frendo JL, et al. 1999. Calcitonin receptor polymorphism is associated with a decreased fracture risk in post-menopausal women.. Hum. Mol. Genet. 7 13: 2129-33. PMID 9817931. Christopoulos G, Perry KJ, Morfis M, et al. 1999. Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product.. Mol. Pharmacol. 56 1: 235-42. PMID 10385705. Nishikawa T, Ishikawa H, Yamamoto S, Koshihara Y 2000. A novel calcitonin receptor gene in human osteoclasts from normal bone marrow.. FEBS Lett. 458 3: 409-14. PMID 10570950. Beaudreuil J, Taboulet J, Orcel P, et al. 2000. Calcitonin receptor mRNA in mononuclear leucocytes from postmenopausal women: decrease during osteoporosis and link to bone markers with specific isoform involvement.. Bone 27 1: 161-8. PMID 10865224. Wada S, Yasuda S, Nagai T, et al. 2001. Regulation of calcitonin receptor by glucocorticoid in human osteoclast-like cells prepared in vitro using receptor activator of nuclear factor-kappaB ligand and macrophage colony-stimulating factor.. Endocrinology 142 4: 1471-8. PMID 11250927. Ogden CA, deCathelineau A, Hoffmann PR, et al. 2001. C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells.. J. Exp. Med. 194 6: 781-95. PMID 11560994. Nosaka Y, Tachi Y, Shimpuku H, et al. 2002. Association of calcitonin receptor gene polymorphism with early marginal bone loss around endosseous implants.. The International journal of oral maxillofacial implants 17 1: 38-43. PMID 11858573. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. External links IUPHAR GPCR Database - Calcitonin receptor family MeSH Calcitonin+receptors This membrane protein-related article is a stub. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened v d e Neuropeptide receptors Hypothalamic hormone receptors CRH - FSH - LHRH - TRH - Somatostatin Pituitary hormone receptors Vasopressin 1A, 1B, 2 - Oxytocin - LHCG - Type I cytokine receptor GH, Prolactin - TSH Other hormone receptors Atrial natriuretic factor - Calcitonin - Cholecystokinin A, B - VIP Opioid receptors Delta - Kappa - Mu - Sigma 1, 2 - Nociceptin Other neuropeptide receptors Angiotensin - Bradykinin B1, B2 / Tachykinin TACR1 - Calcitonin gene-related peptide - Galanin - GPCR neuropeptide B/W, FF, S, Y - Neurotensin Retrieved from http://en..org/wiki/Calcitonin_receptor Categories: Genes on chromosome 7 | Human proteins | Membrane protein stubs | Cell signaling | Signal transductionHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 03:07
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