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14-September-2008 18:02:42 - 2 macrophage Cannabinoid receptor 2 macrophage Identifiers Symbols CNR2; CB2; CX5 External IDs OMIM: 605051 MGI: 104650 HomoloGene: 1389 Gene ontology Molecular function: receptor activity cannabinoid receptor activity Cellular component: plasma membrane integral to plasma membrane Biological process: immune response signal transduction G-protein signaling, coupled to cyclic nucleotide second messenger behavior RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 1269 12802 Ensembl ENSG00000188822 ENSMUSG00000062585 Uniprot P34972 Q544H5 Refseq NM_001841 mRNA NP_001832 protein NM_009924 mRNA NP_034054 protein Location Chr 1: 24.07 - 24.11 Mb Chr 4: 135.17 - 135.19 Mb Pubmed search 1 2 Cannabinoid receptor 2 macrophage, also known as CB2 or CNR2, is a human gene.1 The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 brain CNR1 gene have the characteristics of a guanine nucleotide-binding protein G-protein-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects including alterations in mood and cognition experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors.1 See also Cannabinoid receptor References ^ a b Entrez Gene: CNR2 cannabinoid receptor 2 macrophage. Further reading Oddi S, Spagnuolo P, Bari M, et al. 2007. Differential modulation of type 1 and type 2 cannabinoid receptors along the neuroimmune axis.. Int. Rev. Neurobiol. 82: 327-37. doi:10.1016/S0074-77420782017-4. PMID 17678969. Galiègue S, Mary S, Marchand J, et al. 1995. Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations.. Eur. J. Biochem. 232 1: 54-61. PMID 7556170. Munro S, Thomas KL, Abu-Shaar M 1993. Molecular characterization of a peripheral receptor for cannabinoids.. Nature 365 6441: 61-5. doi:10.1038/365061a0. PMID 7689702. Shire D, Calandra B, Rinaldi-Carmona M, et al. 1996. Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor.. Biochim. Biophys. Acta 1307 2: 132-6. PMID 8679694. Tao Q, McAllister SD, Andreassi J, et al. 1999. Role of a conserved lysine residue in the peripheral cannabinoid receptor CB2: evidence for subtype specificity.. Mol. Pharmacol. 55 3: 605-13. PMID 10051546. Nong L, Newton C, Friedman H, Klein TW 2002. CB1 and CB2 receptor mRNA expression in human peripheral blood mononuclear cells PBMC from various donor types.. Adv. Exp. Med. Biol. 493: 229-33. PMID 11727770. Ho BY, Current L, Drewett JG 2002. Role of intracellular loops of cannabinoid CB1 receptor in functional interaction with Galpha16.. FEBS Lett. 522 1-3: 130-4. PMID 12095632. Matias I, Pochard P, Orlando P, et al. 2002. Presence and regulation of the endocannabinoid system in human dendritic cells.. Eur. J. Biochem. 269 15: 3771-8. PMID 12153574. Song ZH, Feng W 2002. Absence of a conserved proline and presence of a conserved tyrosine in the CB2 cannabinoid receptor are crucial for its function.. FEBS Lett. 531 2: 290-4. PMID 12417328. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Casanova ML, Blázquez C, Martínez-Palacio J, et al. 2003. Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors.. J. Clin. Invest. 111 1: 43-50. PMID 12511587. Feng W, Song ZH 2003. Effects of D3.49A, R3.50A, and A6.34E mutations on ligand binding and activation of the cannabinoid-2 CB2 receptor.. Biochem. Pharmacol. 65 7: 1077-85. PMID 12663043. Kishimoto S, Gokoh M, Oka S, et al. 2003. 2-arachidonoylglycerol induces the migration of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes through the cannabinoid CB2 receptor-dependent mechanism.. J. Biol. Chem. 278 27: 24469-75. doi:10.1074/jbc.M301359200. PMID 12711605. Jorda MA, Rayman N, Valk P, et al. 2003. Identification, characterization, and function of a novel oncogene: the peripheral cannabinoid receptor Cb2.. Ann. N. Y. Acad. Sci. 996: 10-6. PMID 12799277. Benito C, Núñez E, Tolón RM, et al. 2003. Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains.. J. Neurosci. 23 35: 11136-41. PMID 14657172. Rayman N, Lam KH, Laman JD, et al. 2004. Distinct expression profiles of the peripheral cannabinoid receptor in lymphoid tissues depending on receptor activation status.. J. Immunol. 172 4: 2111-7. PMID 14764676. Rao GK, Zhang W, Kaminski NE 2004. Cannabinoid receptor-mediated regulation of intracellular calcium by delta9-tetrahydrocannabinol in resting T cells.. J. Leukoc. Biol. 75 5: 884-92. doi:10.1189/jlb.1203638. PMID 14966196. Alberich Jordà M, Rayman N, Tas M, et al. 2004. The peripheral cannabinoid receptor Cb2, frequently expressed on AML blasts, either induces a neutrophilic differentiation block or confers abnormal migration properties in a ligand-dependent manner.. Blood 104 2: 526-34. doi:10.1182/blood-2003-12-4357. PMID 15039279. Núñez E, Benito C, Pazos MR, et al. 2004. Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: an immunohistochemical study.. Synapse 53 4: 208-13. doi:10.1002/syn.20050. PMID 15266552. Gokoh M, Kishimoto S, Oka S, et al. 2005. 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces rapid actin polymerization in HL-60 cells differentiated into macrophage-like cells.. Biochem. J. 386 Pt 3: 583-9. doi:10.1042/BJ20041163. PMID 15456404. This article incorporates text from the United States National Library of Medicine, which is in the public domain. This transmembrane receptor-related article is a stub. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Cannabinoid_receptor_2_macrophage Categories: Genes on chromosome 1 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture
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