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14-September-2008 18:02:42 - B receptor Cholecystokinin B receptor PDB rendering based on 1l4t. Available structures: 1l4t Identifiers Symbols CCKBR; CCK-B; GASR External IDs OMIM: 118445 MGI: 99479 HomoloGene: 7258 Gene ontology Molecular function: rhodopsin-like receptor activity phosphoinositide phospholipase C activity receptor activity gastrin receptor activity phosphatidylinositol 3-kinase regulator activity Cellular component: plasma membrane integral to plasma membrane Biological process: phospholipase C activation elevation of cytosolic calcium ion concentration digestion sensory perception feeding behavior cell proliferation positive regulation of cell proliferation RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 887 12426 Ensembl ENSG00000110148 ENSMUSG00000030898 Uniprot P32239 Q3ZB46 Refseq NM_176875 mRNA NP_795344 protein NM_007627 mRNA NP_031653 protein Location Chr 11: 6.24 - 6.25 Mb Chr 7: 105.3 - 105.34 Mb Pubmed search 1 2 Cholecystokinin B receptor, also known as CCKBR, is a human gene. This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin CCK, regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors.1 See also Cholecystokinin receptor Cholecystokinin antagonist References ^ Entrez Gene: CCKBR cholecystokinin B receptor. Further reading Herget T, Sethi T, Wu SV, et al. 1994. Cholecystokinin stimulates Ca2+ mobilization and clonal growth in small cell lung cancer through CCKA and CCKB/gastrin receptors.. Ann. N. Y. Acad. Sci. 713: 283-97. PMID 8185170. Pisegna JR, de Weerth A, Huppi K, Wank SA 1992. Molecular cloning of the human brain and gastric cholecystokinin receptor: structure, functional expression and chromosomal localization.. Biochem. Biophys. Res. Commun. 189 1: 296-303. PMID 1280419. Lee YM, Beinborn M, McBride EW, et al. 1993. The human brain cholecystokinin-B/gastrin receptor. Cloning and characterization.. J. Biol. Chem. 268 11: 8164-9. PMID 7681836. Ito M, Iwata N, Taniguchi T, et al. 1995. Functional characterization of two cholecystokinin-B/gastrin receptor isoforms: a preferential splice donor site in the human receptor gene.. Cell Growth Differ. 5 10: 1127-35. PMID 7848914. Miyake A 1995. A truncated isoform of human CCK-B/gastrin receptor generated by alternative usage of a novel exon.. Biochem. Biophys. Res. Commun. 208 1: 230-7. doi:10.1006/bbrc.1995.1328. PMID 7887934. Maruyama K, Sugano S 1994. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.. Gene 138 1-2: 171-4. PMID 8125298. Zimonjic DB, Popescu NC, Matsui T, et al. 1993. Localization of the human cholecystokinin-B/gastrin receptor gene CCKBR to chromosome 11p15.5--p15.4 by fluorescence in situ hybridization.. Cytogenet. Cell Genet. 65 3: 184-5. PMID 8222757. de Weerth A, Pisegna JR, Huppi K, Wank SA 1993. Molecular cloning, functional expression and chromosomal localization of the human cholecystokinin type A receptor.. Biochem. Biophys. Res. Commun. 194 2: 811-8. PMID 8343165. Ito M, Matsui T, Taniguchi T, et al. 1993. Functional characterization of a human brain cholecystokinin-B receptor. A trophic effect of cholecystokinin and gastrin.. J. Biol. Chem. 268 24: 18300-5. PMID 8349705. Song I, Brown DR, Wiltshire RN, et al. 1993. The human gastrin/cholecystokinin type B receptor gene: alternative splice donor site in exon 4 generates two variant mRNAs.. Proc. Natl. Acad. Sci. U.S.A. 90 19: 9085-9. PMID 8415658. Beinborn M, Lee YM, McBride EW, et al. 1993. A single amino acid of the cholecystokinin-B/gastrin receptor determines specificity for non-peptide antagonists.. Nature 362 6418: 348-50. doi:10.1038/362348a0. PMID 8455720. Silvente-Poirot S, Wank SA 1996. A segment of five amino acids in the second extracellular loop of the cholecystokinin-B receptor is essential for selectivity of the peptide agonist gastrin.. J. Biol. Chem. 271 25: 14698-706. PMID 8663021. Tarasova NI, Wank SA, Hudson EA, et al. 1997. Endocytosis of gastrin in cancer cells expressing gastrin/CCK-B receptor.. Cell Tissue Res. 287 2: 325-33. PMID 8995203. Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. 1997. Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.. Gene 200 1-2: 149-56. PMID 9373149. O'Briant KC, Ali SY, Weier HU, Bepler G 1999. An 84-kilobase physical map and repeat polymorphisms of the gastrin/cholecystokinin brain receptor region at the junction of chromosome segments 11p15.4 and 15.5.. Chromosome Res. 6 5: 415-8. PMID 9872672. Monstein HJ, Nilsson I, Ellnebo-Svedlund K, Svensson SP 1999. Cloning and characterization of 5'-end alternatively spliced human cholecystokinin-B receptor mRNAs.. Recept. Channels 6 3: 165-77. PMID 10100325. Daulhac L, Kowalski-Chauvel A, Pradayrol L, et al. 1999. Src-family tyrosine kinases in activation of ERK-1 and p85/p110-phosphatidylinositol 3-kinase by G/CCKB receptors.. J. Biol. Chem. 274 29: 20657-63. PMID 10400698. Silvente-Poirot S, Escrieut C, Galès C, et al. 1999. Evidence for a direct interaction between the penultimate aspartic acid of cholecystokinin and histidine 207, located in the second extracellular loop of the cholecystokinin B receptor.. J. Biol. Chem. 274 33: 23191-7. PMID 10438490. Kulaksiz H, Arnold R, Göke B, et al. 2000. Expression and cell-specific localization of the cholecystokinin B/gastrin receptor in the human stomach.. Cell Tissue Res. 299 2: 289-98. PMID 10741470. This article incorporates text from the United States National Library of Medicine, which is in the public domain. This transmembrane receptor-related article is a stub. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened v d e Neuropeptide receptors Hypothalamic hormone receptors CRH - FSH - LHRH - TRH - Somatostatin Pituitary hormone receptors Vasopressin 1A, 1B, 2 - Oxytocin - LHCG - Type I cytokine receptor GH, Prolactin - TSH Other hormone receptors Atrial natriuretic factor - Calcitonin - Cholecystokinin A, B - VIP Opioid receptors Delta - Kappa - Mu - Sigma 1, 2 - Nociceptin Other neuropeptide receptors Angiotensin - Bradykinin B1, B2 / Tachykinin TACR1 - Calcitonin gene-related peptide - Galanin - GPCR neuropeptide B/W, FF, S, Y - Neurotensin Retrieved from http://en..org/wiki/Cholecystokinin_B_receptor Categories: Genes on chromosome 11 | Human proteins | Transmembrane receptor stubs | Cell signaling | Signal transduction | G protein coupled receptors Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 07:45
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