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14-September-2008 18:02:42 - Coagulation factor II receptor Coagulation factor II thrombin receptor Identifiers Symbols F2R; CF2R; HTR; PAR1; TR External IDs OMIM: 187930 MGI: 101802 HomoloGene: 1510 Gene ontology Molecular function: rhodopsin-like receptor activity receptor activity receptor binding thrombin receptor activity Cellular component: Golgi apparatus plasma membrane integral to plasma membrane Biological process: regulation of progression through cell cycle apoptosis caspase activation cell motility signal transduction G-protein coupled receptor protein signaling pathway tyrosine phosphorylation of STAT protein STAT protein nuclear translocation multicellular organismal development blood coagulation response to wounding anatomical structure morphogenesis positive regulation of I-kappaB kinase/NF-kappaB cascade RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 2149 14062 Ensembl ENSG00000181104 ENSMUSG00000048376 Uniprot P25116 Q3UK34 Refseq NM_001992 mRNA NP_001983 protein NM_010169 mRNA NP_034299 protein Location Chr 5: 76.05 - 76.07 Mb Chr 13: 96.7 - 96.72 Mb Pubmed search 1 2 Coagulation factor II thrombin receptor, also known as F2R or protease activated receptor 1 PAR1 is a human gene. Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member.1 See also Protease-activated receptor References ^ Entrez Gene: F2R coagulation factor II thrombin receptor. Further reading Coughlin SR, Vu TK, Hung DT, Wheaton VI 1992. Characterization of a functional thrombin receptor. Issues and opportunities.. J. Clin. Invest. 89 2: 351-5. PMID 1310691. Howell DC, Laurent GJ, Chambers RC 2002. Role of thrombin and its major cellular receptor, protease-activated receptor-1, in pulmonary fibrosis.. Biochem. Soc. Trans. 30 2: 211-6. doi:10.1042/. PMID 12023853. Tellez C, Bar-Eli M 2003. Role and regulation of the thrombin receptor PAR-1 in human melanoma.. Oncogene 22 20: 3130-7. doi:10.1038/sj.onc.1206453. PMID 12789289. Remillard CV, Yuan JX 2005. PGE2 and PAR-1 in pulmonary fibrosis: a case of biting the hand that feeds you?. Am. J. Physiol. Lung Cell Mol. Physiol. 288 5: L789-92. doi:10.1152/ajplung.00016.2005. PMID 15821019. Leger AJ, Covic L, Kuliopulos A 2006. Protease-activated receptors in cardiovascular diseases.. Circulation 114 10: 1070-7. doi:10.1161/CIRCULATIONAHA.105.574830. PMID 16952995. Traynelis SF, Trejo J 2007. Protease-activated receptor signaling: new roles and regulatory mechanisms.. Curr. Opin. Hematol. 14 3: 230-5. doi:10.1097/MOH.0b013e3280dce568. PMID 17414212. Vu TK, Hung DT, Wheaton VI, Coughlin SR 1991. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation.. Cell 64 6: 1057-68. PMID 1672265. Wojtukiewicz MZ, Tang DG, Ben-Josef E, et al. 1995. Solid tumor cells express functional tethered ligand thrombin receptor.. Cancer Res. 55 3: 698-704. PMID 7834643. Hein L, Ishii K, Coughlin SR, Kobilka BK 1994. Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitization of a G protein-coupled receptor.. J. Biol. Chem. 269 44: 27719-26. PMID 7961693. Mathews II, Padmanabhan KP, Ganesh V, et al. 1994. Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes.. Biochemistry 33 11: 3266-79. PMID 8136362. Offermanns S, Laugwitz KL, Spicher K, Schultz G 1994. G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets.. Proc. Natl. Acad. Sci. U.S.A. 91 2: 504-8. PMID 8290554. Hoffman M, Church FC 1993. Response of blood leukocytes to thrombin receptor peptides.. J. Leukoc. Biol. 54 2: 145-51. PMID 8395550. Bahou WF, Nierman WC, Durkin AS, et al. 1993. Chromosomal assignment of the human thrombin receptor gene: localization to region q13 of chromosome 5.. Blood 82 5: 1532-7. PMID 8395910. Schmidt VA, Vitale E, Bahou WF 1996. Genomic cloning and characterization of the human thrombin receptor gene. Structural similarity to the proteinase activated receptor-2 gene.. J. Biol. Chem. 271 16: 9307-12. PMID 8621593. Li F, Baykal D, Horaist C, et al. 1996. Cloning and identification of regulatory sequences of the human thrombin receptor gene.. J. Biol. Chem. 271 42: 26320-8. PMID 8824285. Shapiro MJ, Trejo J, Zeng D, Coughlin SR 1997. Role of the thrombin receptor's cytoplasmic tail in intracellular trafficking. Distinct determinants for agonist-triggered versus tonic internalization and intracellular localization.. J. Biol. Chem. 271 51: 32874-80. PMID 8955127. Ogino Y, Tanaka K, Shimizu N 1997. Direct evidence for two distinct G proteins coupling with thrombin receptors in human neuroblastoma SH-EP cells.. Eur. J. Pharmacol. 316 1: 105-9. PMID 8982657. Molino M, Bainton DF, Hoxie JA, et al. 1997. Thrombin receptors on human platelets. Initial localization and subsequent redistribution during platelet activation.. J. Biol. Chem. 272 9: 6011-7. PMID 9038223. Renesto P, Si-Tahar M, Moniatte M, et al. 1997. Specific inhibition of thrombin-induced cell activation by the neutrophil proteinases elastase, cathepsin G, and proteinase 3: evidence for distinct cleavage sites within the aminoterminal domain of the thrombin receptor.. Blood 89 6: 1944-53. PMID 9058715. This article incorporates text from the United States National Library of Medicine, which is in the public domain. This transmembrane receptor-related article is a stub. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Coagulation_factor_II_receptor Categories: Genes on chromosome 5 | Human proteins | Transmembrane receptor stubs | Receptors | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 10:51
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