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14-September-2008 18:02:42 - 2 Corticotropin releasing hormone receptor 2 Identifiers Symbols CRHR2; CRFR2 External IDs OMIM: 602034 MGI: 894312 HomoloGene: 55612 Gene ontology Molecular function: receptor activity G-protein coupled receptor activity corticotrophin-releasing factor receptor activity Cellular component: plasma membrane integral to plasma membrane Biological process: signal transduction G-protein coupled receptor protein signaling pathway G-protein signaling, coupled to cAMP nucleotide second messenger RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 1395 12922 Ensembl ENSG00000106113 ENSMUSG00000003476 Uniprot Q13324 Q3UQP0 Refseq NM_001883 mRNA NP_001874 protein NM_009953 mRNA NP_034083 protein Location Chr 7: 30.66 - 30.71 Mb Chr 6: 55.02 - 55.06 Mb Pubmed search 1 2 Corticotropin releasing hormone receptor 2, also known as CRHR2, is a human gene.1 Contents 1 See also 2 References 3 Further reading 4 External links See also Corticotropin releasing hormone receptor References ^ Entrez Gene: CRHR2 corticotropin releasing hormone receptor 2. Further reading Perrin MH, Donaldson CJ, Chen R, et al. 1994. Cloning and functional expression of a rat brain corticotropin releasing factor CRF receptor.. Endocrinology 133 6: 3058-61. PMID 8243338. Liaw CW, Lovenberg TW, Barry G, et al. 1996. Cloning and characterization of the human corticotropin-releasing factor-2 receptor complementary deoxyribonucleic acid.. Endocrinology 137 1: 72-7. PMID 8536644. Donaldson CJ, Sutton SW, Perrin MH, et al. 1996. Cloning and characterization of human urocortin.. Endocrinology 137 5: 2167-70. PMID 8612563. Meyer AH, Ullmer C, Schmuck K, et al. 1997. Localization of the human CRF2 receptor to 7p21-p15 by radiation hybrid mapping and FISH analysis.. Genomics 40 1: 189-90. doi:10.1006/geno.1996.4521. PMID 9070940. Valdenaire O, Giller T, Breu V, et al. 1997. A new functional isoform of the human CRF2 receptor for corticotropin-releasing factor.. Biochim. Biophys. Acta 1352 2: 129-32. PMID 9199241. Gottowik J, Goetschy V, Henriot S, et al. 1998. Labelling of CRF1 and CRF2 receptors using the novel radioligand, 3H-urocortin.. Neuropharmacology 36 10: 1439-46. PMID 9423932. Kostich WA, Chen A, Sperle K, Largent BL 1998. Molecular identification and analysis of a novel human corticotropin-releasing factor CRF receptor: the CRF2gamma receptor.. Mol. Endocrinol. 12 8: 1077-85. PMID 9717834. Willenberg HS, Bornstein SR, Hiroi N, et al. 2000. Effects of a novel corticotropin-releasing-hormone receptor type I antagonist on human adrenal function.. Mol. Psychiatry 5 2: 137-41. PMID 10822340. Reyes TM, Lewis K, Perrin MH, et al. 2001. Urocortin II: a member of the corticotropin-releasing factor CRF neuropeptide family that is selectively bound by type 2 CRF receptors.. Proc. Natl. Acad. Sci. U.S.A. 98 5: 2843-8. doi:10.1073/pnas.051626398. PMID 11226328. Hsu SY, Hsueh AJ 2001. Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor.. Nat. Med. 7 5: 605-11. doi:10.1038/87936. PMID 11329063. Lewis K, Li C, Perrin MH, et al. 2001. Identification of urocortin III, an additional member of the corticotropin-releasing factor CRF family with high affinity for the CRF2 receptor.. Proc. Natl. Acad. Sci. U.S.A. 98 13: 7570-5. doi:10.1073/pnas.121165198. PMID 11416224. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Scherer SW, Cheung J, MacDonald JR, et al. 2003. Human chromosome 7: DNA sequence and biology.. Science 300 5620: 767-72. doi:10.1126/science.1083423. PMID 12690205. Wetzka B, Sehringer B, Schäfer WR, et al. 2004. Expression patterns of CRH, CRH receptors, and CRH binding protein in human gestational tissue at term.. Exp. Clin. Endocrinol. Diabetes 111 3: 154-61. doi:10.1055/s-2003-39778. PMID 12784189. Hillier LW, Fulton RS, Fulton LA, et al. 2003. The DNA sequence of human chromosome 7.. Nature 424 6945: 157-64. doi:10.1038/nature01782. PMID 12853948. Karteris E, Hillhouse EW, Grammatopoulos D 2004. Urocortin II is expressed in human pregnant myometrial cells and regulates myosin light chain phosphorylation: potential role of the type-2 corticotropin-releasing hormone receptor in the control of myometrial contractility.. Endocrinology 145 2: 890-900. doi:10.1210/en.2003-1210. PMID 14592950. Seres J, Bornstein SR, Seres P, et al. 2004. Corticotropin-releasing hormone system in human adipose tissue.. J. Clin. Endocrinol. Metab. 89 2: 965-70. PMID 14764822. Brandenberger R, Wei H, Zhang S, et al. 2005. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.. Nat. Biotechnol. 22 6: 707-16. doi:10.1038/nbt971. PMID 15146197. Nanda SA, Roseboom PH, Nash GA, et al. 2004. Characterization of the human corticotropin-releasing factor2a receptor promoter: regulation by glucocorticoids and the cyclic adenosine 5'-monophosphate pathway.. Endocrinology 145 12: 5605-15. doi:10.1210/en.2004-0907. PMID 15331578. Gerhard DS, Wagner L, Feingold EA, et al. 2004. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection MGC.. Genome Res. 14 10B: 2121-7. doi:10.1101/gr.2596504. PMID 15489334. External links IUPHAR GPCR Database - Corticotropin-releasing factor receptors MeSH Corticotropin-releasing+hormone+receptors v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened This transmembrane receptor-related article is a stub. This article incorporates text from the United States National Library of Medicine, which is in the public domain. Retrieved from http://en..org/wiki/Corticotropin_releasing_hormone_receptor_2 Categories: Genes on chromosome 7 | Human proteins | Transmembrane receptor stubs | G protein coupled receptors | Corticotropin-releasing hormoneHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 11:37
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