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14-September-2008 18:02:42 - 2 Cysteinyl leukotriene receptor 2 Identifiers Symbols CYSLTR2; GPCR; CYSLT2; CYSLT2R; HG57; HPN321; KPG_011; PSEC0146; hGPCR21 External IDs OMIM: 605666 MGI: 1917336 HomoloGene: 10688 Gene ontology Molecular function: cysteinyl leukotriene receptor activity receptor activity Cellular component: cellular_component membrane integral to membrane Biological process: immune response signal transduction G-protein coupled receptor protein signaling pathway RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 57105 70086 Ensembl ENSG00000152207 ENSMUSG00000033470 Uniprot Q9NS75 Q8R528 Refseq NM_020377 mRNA NP_065110 protein NM_133720 mRNA NP_598481 protein Location Chr 13: 48.18 - 48.18 Mb Chr 14: 71.76 - 71.78 Mb Pubmed search 1 2 Cysteinyl leukotriene receptor 2, also known as CYSLTR2, is a human gene.1 The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems.1 See also Eicosanoid receptor References ^ a b Entrez Gene: CYSLTR2 cysteinyl leukotriene receptor 2. Further reading Van Keer C, Kersters K, De Ley J 1976. L-Sorbose metabolism in Agrobacterium tumefaciens.. Antonie Van Leeuwenhoek 42 1-2: 13-24. PMID 1085123. Heise CE, O'Dowd BF, Figueroa DJ, et al. 2000. Characterization of the human cysteinyl leukotriene 2 receptor.. J. Biol. Chem. 275 39: 30531-6. doi:10.1074/jbc.M003490200. PMID 10851239. Takasaki J, Kamohara M, Matsumoto M, et al. 2000. The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT2 receptor.. Biochem. Biophys. Res. Commun. 274 2: 316-22. doi:10.1006/bbrc.2000.3140. PMID 10913337. Nothacker HP, Wang Z, Zhu Y, et al. 2001. Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist.. Mol. Pharmacol. 58 6: 1601-8. PMID 11093801. Mita H, Hasegawa M, Saito H, Akiyama K 2002. Levels of cysteinyl leukotriene receptor mRNA in human peripheral leucocytes: significantly higher expression of cysteinyl leukotriene receptor 2 mRNA in eosinophils.. Clin. Exp. Allergy 31 11: 1714-23. PMID 11696047. Takeda S, Kadowaki S, Haga T, et al. 2002. Identification of G protein-coupled receptor genes from the human genome sequence.. FEBS Lett. 520 1-3: 97-101. PMID 12044878. Shirasaki H, Kanaizumi E, Watanabe K, et al. 2003. Expression and localization of the cysteinyl leukotriene 1 receptor in human nasal mucosa.. Clin. Exp. Allergy 32 7: 1007-12. PMID 12100046. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Sjöström M, Johansson AS, Schröder O, et al. 2004. Dominant expression of the CysLT2 receptor accounts for calcium signaling by cysteinyl leukotrienes in human umbilical vein endothelial cells.. Arterioscler. Thromb. Vasc. Biol. 23 8: e37-41. doi:10.1161/01.ATV.0000082689.46538.DF. PMID 12816881. Mellor EA, Frank N, Soler D, et al. 2003. Expression of the type 2 receptor for cysteinyl leukotrienes CysLT2R by human mast cells: Functional distinction from CysLT1R.. Proc. Natl. Acad. Sci. U.S.A. 100 20: 11589-93. doi:10.1073/pnas.2034927100. PMID 13679572. Thompson MD, Storm van's Gravesande K, Galczenski H, et al. 2004. A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha.. Pharmacogenetics 13 10: 641-9. doi:10.1097/01.fpc.0000054127.14659.42. PMID 14515063. Dunham A, Matthews LH, Burton J, et al. 2004. The DNA sequence and analysis of human chromosome 13.. Nature 428 6982: 522-8. doi:10.1038/nature02379. PMID 15057823. Fukai H, Ogasawara Y, Migita O, et al. 2005. Association between a polymorphism in cysteinyl leukotriene receptor 2 on chromosome 13q14 and atopic asthma.. Pharmacogenetics 14 10: 683-90. PMID 15454733. Pillai SG, Cousens DJ, Barnes AA, et al. 2005. A coding polymorphism in the CYSLT2 receptor with reduced affinity to LTD4 is associated with asthma.. Pharmacogenetics 14 9: 627-33. PMID 15475736. Gerhard DS, Wagner L, Feingold EA, et al. 2004. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection MGC.. Genome Res. 14 10B: 2121-7. doi:10.1101/gr.2596504. PMID 15489334. Hui Y, Cheng Y, Smalera I, et al. 2005. Directed vascular expression of human cysteinyl leukotriene 2 receptor modulates endothelial permeability and systemic blood pressure.. Circulation 110 21: 3360-6. doi:10.1161/01.CIR.0000147775.50954.AA. PMID 15545522. Corrigan C, Mallett K, Ying S, et al. 2005. Expression of the cysteinyl leukotriene receptors cysLT1 and cysLT2 in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis.. J. Allergy Clin. Immunol. 115 2: 316-22. doi:10.1016/j.jaci.2004.10.051. PMID 15696087. Uzonyi B, Lötzer K, Jahn S, et al. 2006. Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells.. Proc. Natl. Acad. Sci. U.S.A. 103 16: 6326-31. doi:10.1073/pnas.0601223103. PMID 16606835. Woszczek G, Chen LY, Nagineni S, et al. 2007. IFN-gamma induces cysteinyl leukotriene receptor 2 expression and enhances the responsiveness of human endothelial cells to cysteinyl leukotrienes.. J. Immunol. 178 8: 5262-70. PMID 17404310. Klotsman M, York TP, Pillai SG, et al. 2007. Pharmacogenetics of the 5-lipoxygenase biosynthetic pathway and variable clinical response to montelukast.. Pharmacogenet. Genomics 17 3: 189-96. doi:10.1097/FPC.0b013e3280120043. PMID 17460547. This transmembrane receptor-related article is a stub. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened This article incorporates text from the United States National Library of Medicine, which is in the public domain. Retrieved from http://en..org/wiki/Cysteinyl_leukotriene_receptor_2 Categories: Genes on chromosome 13 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 13:17
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