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14-September-2008 18:02:42 - delta Opioid receptor Opioid receptor, delta 1 Identifiers Symbols OPRD1; OPRD External IDs OMIM: 165195 MGI: 97438 HomoloGene: 20252 Gene ontology Molecular function: rhodopsin-like receptor activity receptor activity delta-opioid receptor activity Cellular component: membrane fraction plasma membrane integral to plasma membrane Biological process: immune response signal transduction G-protein signaling, coupled to cyclic nucleotide second messenger G-protein signaling, adenylate cyclase inhibiting pathway neuropeptide signaling pathway sensory perception adult locomotory behavior RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 4985 18386 Ensembl ENSG00000116329 n/a Uniprot P41143 n/a Refseq NM_000911 mRNA NP_000902 protein XM_973497 mRNA XP_978591 protein Location Chr 1: 29.01 - 29.06 Mb n/a Pubmed search 1 2 The δ-opioid receptors, also known as delta opioid receptor or simply delta receptor, abbreviated DOR, is an opioid receptor that has enkephalins as their endogenous ligands.1 Contents 1 Function 2 References 3 Further reading 4 External links Function Until comparatively recently, there were few pharmacological tools for the study of δ receptors. As a consequence, our understanding of their function is much more limited than those of the other opioid receptors for which selective ligands have long been available. However there are now several selective delta opioid agonists available, including peptides such as DPDPE and deltorphin II, and non-peptide drugs such as SNC-80,2 the more potent +-BW373U86,3 a newer drug DPI-287 which does not produce the problems with convulsions seen with the earlier agents,4 and the mixed mu/delta agonist DPI-3290 which is a much more potent analgesic than the more highly selective delta agonists.5 Selective antagonists for the delta receptor are also available, with the best known being the opiate derivative naltrindole.6 Activation of delta receptors produces some analgesia, although less than that of mu-opioid agonists.7 Many delta agonists may also cause seizures at high doses, although not all delta agonists produce this effect.8 Evidence for whether delta agonists produce respiratory depression is mixed; high doses of the delta agonist peptide DPDPE produced respiratory depression in sheep,9 but in tests on mice the non-peptide delta agonist SNC-80 produced respiratory depression only at the very high dose of 40 mg/kg.10 In contrast both the peptide delta agonist Deltorphin II and the non-peptide delta agonist +-BW373U86 actually stimulated respiratory function and blocked the respiratory depressant effect of the potent mu-opioid agonist alfentanil, without affecting pain relief.11 It thus seems likely that while delta opioid agonists can produce respiratory depression at very high doses, at lower doses they have the opposite effect, a fact which may make mixed mu/delta agonists such as DPI-3290 potentially very useful drugs which might be much safer than the mu agonists currently used for pain relief. Of most interest however is the potential for delta agonists to be developed for use as a novel class of antidepressant drugs, following robust evidence of both antidepressant effects12 and also upregulation of BDNF production in the brain in animal models of depression.13 These antidepressant effects have been linked to endogenous opioid peptides acting at delta and mu opioid receptors,14 and so can also be produced by enkephalinase inhibitors such as RB-101.15 Recent work indicates that exogenous ligands which activate the delta receptors mimic the phenomenon known as ischemic preconditioning.16 Experimentally, if short periods of transient ischemia are induced the downstream tissues are robustly protected if longer-duration interruption of the blood supply is then effected. Opiates and opioids with delta activity mimic this effect. In the rat model introduction of delta active ligands results in significant cardioprotection.17 Image:Delta_opioid_ligands.png References ^ Quock RM, Burkey TH, Varga E, Hosohata Y, Hosohata K, Cowell SM, Slate CA, Ehlert FJ, Roeske WR, Yamamura HI 1999. The delta-opioid receptor: molecular pharmacology, signal transduction, and the determination of drug efficacy. Pharmacol. Rev. 51 3: 503-32. PMID 10471416. ^ Calderon SN, Rothman RB, Porreca F, Flippen-Anderson JL, McNutt RW, Xu H, Smith LE, Bilsky EJ, Davis P, Rice KC 1994. Probes for narcotic receptor mediated phenomena. 19. Synthesis of +-4-alpha R-alpha-2S,5R-4-allyl-2,5-dimethyl-1-piperazinyl-3- methoxybenzyl-N,N-diethylbenzamide SNC 80: a highly selective, nonpeptide delta opioid receptor agonist. J. Med. Chem. 37 14: 2125-8. doi:10.1021/jm00040a002. PMID 8035418. ^ Calderon SN, Rice KC, Rothman RB, Porreca F, Flippen-Anderson JL, Kayakiri H, Xu H, Becketts K, Smith LE, Bilsky EJ, Davis P, Horvath R 1997. Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective delta agonist +-4-alpha R-alpha-2S,5R-4-Allyl-2,5-dimethyl-1-piperazinyl-3-methoxybenzyl- N,N-diethylbenzamide SNC 80 and related novel nonpeptide delta opioid receptor ligands. J. Med. Chem. 40 5: 695-704. doi:10.1021/jm960319n. PMID 9057856. ^ Jutkiewicz EM 2006. The antidepressant -like effects of delta-opioid receptor agonists. Mol. Interv. 6 3: 162-9. doi:10.1124/mi.6.3.7. PMID 16809477. ^ Ananthan S 2006. Opioid ligands with mixed mu/delta opioid receptor interactions: an emerging approach to novel analgesics. AAPS J 8 1: E118-25. doi:10.1208/aapsj080114. PMID 16584118. ^ Portoghese PS, Sultana M, Takemori AE 1988. Naltrindole, a highly selective and potent non-peptide delta opioid receptor antagonist. Eur. J. Pharmacol. 146 1: 185-6. doi:10.1016/0014-29998890502-X. PMID 2832195. ^ Varga EV, Navratilova E, Stropova D, Jambrosic J, Roeske WR, Yamamura HI 2004. Agonist-specific regulation of the delta-opioid receptor. Life Sci. 76 6: 599-612. doi:10.1016/j.lfs.2004.07.020. PMID 15567186. ^ Jutkiewicz EM, Baladi MG, Folk JE, Rice KC, Woods JH 2006. The convulsive and electroencephalographic changes produced by nonpeptidic delta-opioid agonists in rats: comparison with pentylenetetrazol. J. Pharmacol. Exp. Ther. 317 3: 1337-48. doi:10.1124/jpet.105.095810. PMID 16537798. ^ Clapp JF, Kett A, Olariu N, Omoniyi AT, Wu D, Kim H, Szeto HH 1998. Cardiovascular and metabolic responses to two receptor-selective opioid agonists in pregnant sheep. Am. J. Obstet. Gynecol. 178 2: 397-401. PMID 9500506. ^ Gallantine EL, Meert TF 2005. A comparison of the antinociceptive and adverse effects of the mu-opioid agonist morphine and the delta-opioid agonist SNC80. Basic Clin. Pharmacol. Toxicol. 97 1: 39-51. doi:10.1111/j.1742-7843.2005.pto_07.x. PMID 15943758. ^ Su YF, McNutt RW, Chang KJ 1998. Delta-opioid ligands reverse alfentanil-induced respiratory depression but not antinociception. J. Pharmacol. Exp. Ther. 287 3: 815-23. PMID 9864259. ^ Broom DC, Jutkiewicz EM, Rice KC, Traynor JR, Woods JH 2002. Behavioral effects of delta-opioid receptor agonists: potential antidepressants?. Jpn. J. Pharmacol. 90 1: 1-6. doi:10.1254/jjp.90.1. PMID 12396021. ^ Torregrossa MM, Jutkiewicz EM, Mosberg HI, Balboni G, Watson SJ, Woods JH 2006. Peptidic delta opioid receptor agonists produce antidepressant-like effects in the forced swim test and regulate BDNF mRNA expression in rats. Brain Res. 1069 1: 172-81. doi:10.1016/j.brainres.2005.11.005. PMID 16364263. ^ Zhang H, Torregrossa MM, Jutkiewicz EM, Shi YG, Rice KC, Woods JH, Watson SJ, Ko MC 2006. Endogenous opioids upregulate brain-derived neurotrophic factor mRNA through delta- and micro-opioid receptors independent of antidepressant-like effects. Eur. J. Neurosci. 23 4: 984-94. doi:10.1111/j.1460-9568.2006.04621.x. PMID 16519663. ^ Jutkiewicz EM, Torregrossa MM, Sobczyk-Kojiro K, Mosberg HI, Folk JE, Rice KC, Watson SJ, Woods JH 2006. Behavioral and neurobiological effects of the enkephalinase inhibitor RB101 relative to its antidepressant effects. Eur. J. Pharmacol. 531 1-3: 151-9. doi:10.1016/j.ejphar.2005.12.002. PMID 16442521. ^ Zhang J, Qian H, Zhao P, Hong SS, Xia Y 2006. Rapid hypoxia preconditioning protects cortical neurons from glutamate toxicity through delta-opioid receptor. Stroke 37 4: 1094-9. doi:10.1161/01.STR.0000206444.29930.18. PMID 16514101. ^ Guo L, Zhang L, Zhang DC 2005. Mechanisms of delta-opioids cardioprotective effects in ischemia and its potential clinical applications in Chinese. Sheng li ke xue jin zhan Progress in physiology 36 4: 333-6. PMID 16408774. Further reading Narita M, Funada M, Suzuki T 2001. Regulations of opioid dependence by opioid receptor types.. Pharmacol. Ther. 89 1: 1-15. PMID 11316510. Evans CJ, Keith DE, Morrison H, et al. 1993. Cloning of a delta opioid receptor by functional expression.. Science 258 5090: 1952-5. PMID 1335167. Offermanns S, Schultz G, Rosenthal W 1991. Evidence for opioid receptor-mediated activation of the G-proteins, Go and Gi2, in membranes of neuroblastoma x glioma NG108-15 hybrid cells.. J. Biol. Chem. 266 6: 3365-8. PMID 1671672. Simonin F, Befort K, Gavériaux-Ruff C, et al. 1995. The human delta-opioid receptor: genomic organization, cDNA cloning, functional expression, and distribution in human brain.. Mol. Pharmacol. 46 6: 1015-21. PMID 7808419. Befort K, Mattéi MG, Roeckel N, Kieffer B 1994. Chromosomal localization of the delta opioid receptor gene to human 1p34.3-p36.1 and mouse 4D bands by in situ hybridization.. Genomics 20 1: 143-5. PMID 8020949. Knapp RJ, Malatynska E, Fang L, et al. 1994. Identification of a human delta opioid receptor: cloning and expression.. Life Sci. 54 25: PL463-9. PMID 8201839. Georgoussi Z, Carr C, Milligan G 1993. Direct measurements of in situ interactions of rat brain opioid receptors with the guanine nucleotide-binding protein Go.. Mol. Pharmacol. 44 1: 62-9. PMID 8393523. Bzdega T, Chin H, Kim H, et al. 1993. Regional expression and chromosomal localization of the delta opiate receptor gene.. Proc. Natl. Acad. Sci. U.S.A. 90 20: 9305-9. PMID 8415697. Ho MK, Wong YH 1997. Functional role of amino-terminal serine16 and serine27 of G alphaZ in receptor and effector coupling.. J. Neurochem. 68 6: 2514-22. PMID 9166747. Hedin KE, Bell MP, Kalli KR, et al. 1998. Delta-opioid receptors expressed by Jurkat T cells enhance IL-2 secretion by increasing AP-1 complexes and activity of the NF-AT/AP-1-binding promoter element.. J. Immunol. 159 11: 5431-40. PMID 9548483. Jordan BA, Devi LA 1999. G-protein-coupled receptor heterodimerization modulates receptor function.. Nature 399 6737: 697-700. doi:10.1038/21441. PMID 10385123. Petaja-Repo UE, Hogue M, Laperriere A, et al. 2000. Export from the endoplasmic reticulum represents the limiting step in the maturation and cell surface expression of the human delta opioid receptor.. J. Biol. Chem. 275 18: 13727-36. PMID 10788493. Gelernter J, Kranzler HR 2000. Variant detection at the delta opioid receptor OPRD1 locus and population genetics of a novel variant affecting protein sequence.. Hum. Genet. 107 1: 86-8. PMID 10982041. Guo J, Wu Y, Zhang W, et al. 2000. Identification of G protein-coupled receptor kinase 2 phosphorylation sites responsible for agonist-stimulated delta-opioid receptor phosphorylation.. Mol. Pharmacol. 58 5: 1050-6. PMID 11040053. Gomes I, Jordan BA, Gupta A, et al. 2001. Heterodimerization of mu and delta opioid receptors: A role in opiate synergy.. J. Neurosci. 20 22: RC110. PMID 11069979. Xu W, Chen C, Huang P, et al. 2000. The conserved cysteine 7.38 residue is differentially accessible in the binding-site crevices of the mu, delta, and kappa opioid receptors.. Biochemistry 39 45: 13904-15. PMID 11076532. Hartley JL, Temple GF, Brasch MA 2001. DNA cloning using in vitro site-specific recombination.. Genome Res. 10 11: 1788-95. PMID 11076863. Saeed RW, Stefano GB, Murga JD, et al. 2001. Expression of functional delta opioid receptors in vascular smooth muscle.. Int. J. Mol. Med. 6 6: 673-7. PMID 11078827. Xiang B, Yu GH, Guo J, et al. 2001. Heterologous activation of protein kinase C stimulates phosphorylation of delta-opioid receptor at serine 344, resulting in beta-arrestin- and clathrin-mediated receptor internalization.. J. Biol. Chem. 276 7: 4709-16. doi:10.1074/jbc.M006187200. PMID 11085981. Yeo A, Samways DS, Fowler CE, et al. 2001. Coincident signalling between the Gi/Go-coupled delta-opioid receptor and the Gq-coupled m3 muscarinic receptor at the level of intracellular free calcium in SH-SY5Y cells.. J. Neurochem. 76 6: 1688-700. PMID 11259487. External links IUPHAR GPCR Database - δ opioid receptor MeSH delta+Opioid+Receptor v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened v d e Neuropeptide receptors Hypothalamic hormone receptors CRH - FSH - LHRH - TRH - Somatostatin Pituitary hormone receptors Vasopressin 1A, 1B, 2 - Oxytocin - LHCG - Type I cytokine receptor GH, Prolactin - TSH Other hormone receptors Atrial natriuretic factor - Calcitonin - Cholecystokinin A, B - VIP Opioid receptors Delta - Kappa - Mu - Sigma 1, 2 - Nociceptin Other neuropeptide receptors Angiotensin - Bradykinin B1, B2 / Tachykinin TACR1 - Calcitonin gene-related peptide - Galanin - GPCR neuropeptide B/W, FF, S, Y - Neurotensin Retrieved from http://en..org/wiki/Delta_Opioid_receptor Categories: Genes on chromosome 1 | Human proteins | Cell signaling | Signal transduction | G protein coupled receptors | Opioid receptorHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 18:05
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