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14-September-2008 18:02:49 - Disintegrin Redirected from Disintegrins Structure of disintegrin heterodimer from Echis carinatus. Structure of disintegrin heterodimer from Echis carinatus. Disintegrins are peptides isolated from the venom of various snakes of the viper family. They interact with the beta 1 and beta 3 families of integrin proteins. Disintegrins are cysteine-rich peptides ranging from 45 to 84 amino acids in length and almost all of them contain an Arg-Gly-Asp RGD sequence, a recognition site of many adhesion proteins. They work by countering the blood clotting steps, inhibiting the clumping of platelets. Examples of disintegrins are: albolabrin, applagin, barbourin, batroxostatin, bitistatin, echistatin, elegantin, eristicophin, flavoridin, halysin, kistrin, tergeminin and triflavin. The term disintegrin was first proposed by R. J. Gould et al. in 1989. See also ADAM Protein External links MeSH Disintegrins This protein-related article is a stub. Retrieved from http://en..org/wiki/Disintegrin Categories: Proteins | Protein stubs Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Português This page was last modified on 19 June 2008, at 00:3
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