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14-September-2008 18:02:42 - D5 The correct title of this article is Dopamine receptor D5. It appears incorrectly here because of technical restrictions. Dopamine receptor D5 Identifiers Symbols DRD5; DBDR; DRD1B; DRD1L2; MGC10601 External IDs OMIM: 126453 MGI: 94927 HomoloGene: 20216 Gene ontology Molecular function: rhodopsin-like receptor activity receptor activity dopamine receptor activity Cellular component: integral to plasma membrane membrane Biological process: signal transduction G-protein coupled receptor protein signaling pathway dopamine receptor, adenylate cyclase activating pathway synaptic transmission RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 1816 13492 Ensembl ENSG00000169676 ENSMUSG00000039358 Uniprot P21918 Q8BLD9 Refseq NM_000798 mRNA NP_000789 protein NM_013503 mRNA NP_038531 protein Location Chr 4: 9.39 - 9.39 Mb Chr 5: 38.61 - 38.61 Mb Pubmed search 1 2 Dopamine receptor D5, also known as DRD5, is a human gene.12 This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase.3 This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2.1 Contents 1 Ligands 1.1 Agonists 1.2 Antagonists 2 See also 3 References 4 Further reading 5 External links Ligands The D1 and D5 receptors have a high degree of structural homology and few ligands are available that can distinguish between them as yet, however there are a number of ligands that are selective for D1/5 over the other dopamine receptors. The recent development of a selective D5 antagonist has allowed the action of D1-mediated responses to be studied in the absence of a D5 component, but no selective D5 agonists are yet available. Agonists None known as yet. Antagonists 4-Chloro-7-methyl-5,6,7,8,9,14-hexahydrodibenzd,gazecin-3-ol: antagonist, moderate binding selectivity over D14 Chemical structure of a D5-prefering ligand 4-chloro-7-methyl-5,6,7,8,9,14-hexahydrodibenzd,gazecin-3-ol. Chemical structure of a D5-prefering ligand 4-chloro-7-methyl-5,6,7,8,9,14-hexahydrodibenzd,gazecin-3-ol.4 See also Dopamine receptor References ^ a b Entrez Gene: DRD5 dopamine receptor D5. ^ Polymeropoulos MH, Xiao H, Merril CR 1991. The human D5 dopamine receptor DRD5 maps on chromosome 4. Genomics 11 3: 777-8. doi:10.1016/0888-75439190091-R. PMID 1774076. ^ Sidhu A 1998. Coupling of D1 and D5 dopamine receptors to multiple G proteins: Implications for understanding the diversity in receptor-G protein coupling. Mol. Neurobiol. 16 2: 125-34. doi:10.1007/BF02740640. PMID 9588624. ^ a b Mohr P, Decker M, Enzensperger C, Lehmann J 2006. Dopamine/serotonin receptor ligands. 121: SAR studies on hexahydro-dibenzd,gazecines lead to 4-chloro-7-methyl-5,6,7,8,9,14-hexahydrodibenzd,gazecin-3-ol, the first picomolar D5-selective dopamine-receptor antagonist. J. Med. Chem. 49 6: 2110-6. doi:10.1021/jm051237e. PMID 16539400. Further reading Missale C, Nash SR, Robinson SW, et al. 1998. Dopamine receptors: from structure to function.. Physiol. Rev. 78 1: 189-225. PMID 9457173. Grandy DK, Allen LJ, Zhang Y, et al. 1992. Chromosomal localization of three human D5 dopamine receptor genes.. Genomics 13 4: 968-73. PMID 1387108. Eubanks JH, Altherr M, Wagner-McPherson C, et al. 1992. Localization of the D5 dopamine receptor gene to human chromosome 4p15.1-p15.3, centromeric to the Huntington's disease locus.. Genomics 12 3: 510-6. PMID 1532789. Polymeropoulos MH, Xiao H, Merril CR 1992. The human D5 dopamine receptor DRD5 maps on chromosome 4.. Genomics 11 3: 777-8. PMID 1774076. Sunahara RK, Guan HC, O'Dowd BF, et al. 1991. Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.. Nature 350 6319: 614-9. doi:10.1038/350614a0. PMID 1826762. Tiberi M, Jarvie KR, Silvia C, et al. 1991. Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor.. Proc. Natl. Acad. Sci. U.S.A. 88 17: 7491-5. PMID 1831904. Grandy DK, Zhang YA, Bouvier C, et al. 1991. Multiple human D5 dopamine receptor genes: a functional receptor and two pseudogenes.. Proc. Natl. Acad. Sci. U.S.A. 88 20: 9175-9. PMID 1833775. Weinshank RL, Adham N, Macchi M, et al. 1991. Molecular cloning and characterization of a high affinity dopamine receptor D1 beta and its pseudogene.. J. Biol. Chem. 266 33: 22427-35. PMID 1834671. Sobell JL, Lind TJ, Sigurdson DC, et al. 1995. The D5 dopamine receptor gene in schizophrenia: identification of a nonsense change and multiple missense changes but lack of association with disease.. Hum. Mol. Genet. 4 4: 507-14. PMID 7633397. Beischlag TV, Marchese A, Meador-Woodruff JH, et al. 1995. The human dopamine D5 receptor gene: cloning and characterization of the 5'-flanking and promoter region.. Biochemistry 34 17: 5960-70. PMID 7727453. Sherrington R, Mankoo B, Attwood J, et al. 1994. Cloning of the human dopamine D5 receptor gene and identification of a highly polymorphic microsatellite for the DRD5 locus that shows tight linkage to the chromosome 4p reference marker RAF1P1.. Genomics 18 2: 423-5. doi:10.1006/geno.1993.1489. PMID 8288248. Sidhu A, Kimura K, Uh M, et al. 1998. Multiple coupling of human D5 dopamine receptors to guanine nucleotide binding proteins Gs and Gz.. J. Neurochem. 70 6: 2459-67. PMID 9603210. Cargill M, Altshuler D, Ireland J, et al. 1999. Characterization of single-nucleotide polymorphisms in coding regions of human genes.. Nat. Genet. 22 3: 231-8. doi:10.1038/10290. PMID 10391209. Liu F, Wan Q, Pristupa ZB, et al. 2000. Direct protein-protein coupling enables cross-talk between dopamine D5 and gamma-aminobutyric acid A receptors.. Nature 403 6767: 274-80. doi:10.1038/35002014. PMID 10659839. Misbahuddin A, Placzek MR, Chaudhuri KR, et al. 2004. A polymorphism in the dopamine receptor DRD5 is associated with blepharospasm.. Neurology 58 1: 124-6. PMID 11781417. Kabbani N, Negyessy L, Lin R, et al. 2002. Interaction with neuronal calcium sensor NCS-1 mediates desensitization of the D2 dopamine receptor.. J. Neurosci. 22 19: 8476-86. PMID 12351722. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Hemby SE, Trojanowski JQ, Ginsberg SD 2003. Neuron-specific age-related decreases in dopamine receptor subtype mRNAs.. J. Comp. Neurol. 456 2: 176-83. doi:10.1002/cne.10525. PMID 12509874. Zheng S, Yu P, Zeng C, et al. 2003. Galpha12- and Galpha13-protein subunit linkage of D5 dopamine receptors in the nephron.. Hypertension 41 3: 604-10. doi:10.1161/01.HYP.0000057422.75590.D7. PMID 12623966. External links MeSH DRD5+protein,+human This article incorporates text from the United States National Library of Medicine, which is in the public domain. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened This transmembrane receptor-related article is a stub. Retrieved from http://en..org/wiki/Dopamine_receptor_D5 Categories: Genes on chromosome 4 | Human proteins | G protein coupled receptors | Transmembrane receptor stubsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 27 July 2008, at 02:54
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