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14-September-2008 18:02:49 - EC number This article is about the Enzyme Commission codes. For the European Commission system for coding chemicals, see EC-No. The Enzyme Commission number EC number is a numerical classification scheme for enzymes, based on the chemical reactions they catalyze. As a system of enzyme nomenclature, every EC number is associated with a recommended name for the respective enzyme. Strictly speaking, EC numbers do not specify enzymes, but enzyme-catalyzed reactions. If different enzymes for instance from different organisms catalyze the same reaction, then they receive the same EC number. By contrast, UniProt identifiers uniquely specify a protein by its amino acid sequence.1 Contents 1 Format of number 2 Top level codes 3 History 4 References 5 See also Format of number Every enzyme code consists of the letters EC followed by four numbers separated by periods. Those numbers represent a progressively finer classification of the enzyme. For example, the tripeptide aminopeptidases have the code EC 3.4.11.4, whose components indicate the following groups of enzymes: EC 3 enzymes are hydrolases enzymes that use water to break up some other molecule EC 3.4 are hydrolases that act on peptide bonds EC 3.4.11 are those hydrolases that cleave off the amino-terminal amino acid from a polypeptide EC 3.4.11.4 are those that cleave off the amino-terminal end from a tripeptide Top level codes Top-level EC numbers2 Group Reaction catalyzed Typical reaction Enzyme examples with trivial name EC 1 Oxidoreductases To catalyze oxidation/reduction reactions; transfer of H and O atoms or electrons from one substance to another AH + B → A + BH reduced A + O → AO oxidized Dehydrogenase, oxidase EC 2 Transferases Transfer of a functional group from one substance to another. The group may be methyl-, acyl-, amino- or phosphate group AB + C → A + BC Transaminase, kinase EC 3 Hydrolases Formation of two products from a substrate by hydrolysis AB + H2O → AOH + BH Lipase, amylase, peptidase EC 4 Lyases Non-hydrolytic addition or removal of groups from substrates. C-C, C-N, C-O or C-S bonds may be cleaved RCOCOOH → RCOH + CO2 Decarboxylase EC 5 Isomerases Intramolecule rearrangement, i.e. isomerization changes within a single molecule AB → BA Isomerase, mutase EC 6 Ligases Join together two molecules by synthesis of new C-O, C-S, C-N or C-C bonds with simultaneous breakdown of ATP X + Y+ ATP → XY + ADP + Pi Synthetase History The enzyme nomenclature scheme was developed starting in 1955, when the International Congress of Biochemistry in Brussels set up an Enzyme Commission. The first version was published in 1961. The current sixth ion, published by the International Union of Biochemistry and Molecular Biology in 1992, contains 3196 different enzymes. References ^ ENZYME Enzyme nomenclature database. ExPASy. Retrieved on 2006-03-14. ^ Moss, G.P.. Recommendations of the Nomenclature Committee. International Union of Biochemistry and Molecular Biology on the Nomenclature and Classification of Enzymes by the Reactions they Catalyse. Retrieved on 2006-03-14. See also TC number classification of membrane transport proteins List of enzymes v d e Proteins: enzymes Topics Active site - Allosteric regulation - Binding site - Catalytically perfect enzyme - Coenzyme - Cofactor - Cooperativity - EC number Enzyme catalysis - Enzyme inhibitor - Enzyme kinetics - Lineweaver-Burk plot - Michaelis-Menten kinetics - List of enzymes Types EC1 Oxidoreductases/list - EC2 Transferases/list - EC3 Hydrolases/list - EC4 Lyases/list - EC5 Isomerases/list - EC6 Ligases/list Retrieved from http://en..org/wiki/EC_number Categories: Enzymes | Classification systems Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages العربية Català Dansk Deutsch Español Français Bahasa Indonesia Italiano Nederlands 日本語 Polski Português РуÑ?Ñ?кий Türkçe ä¸æ–‡ This page was last modified on 4 September 2008, at 11:26
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