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14-September-2008 18:02:42 - EDG8 Endothelial differentiation, sphingolipid G-protein-coupled receptor, 8 Identifiers Symbols EDG8; Edg-8; S1P5; S1PR5; SPPR-1; SPPR-2 External IDs OMIM: 605146 MGI: 2150641 HomoloGene: 11031 Gene ontology Molecular function: lysosphingolipid and lysophosphatidic acid receptor activity receptor activity Cellular component: membrane integral to membrane Biological process: signal transduction G-protein coupled receptor protein signaling pathway RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 53637 94226 Ensembl ENSG00000180739 ENSMUSG00000045087 Uniprot Q9H228 Q91X56 Refseq NM_030760 mRNA NP_110387 protein NM_053190 mRNA NP_444420 protein Location Chr 19: 10.48 - 10.49 Mb Chr 9: 20.99 - 21 Mb Pubmed search 1 2 EDG8 endothelial differentiation gene 1 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate S1P. Hence this receptor is also known as S1P5.1 Contents 1 See also 2 References 3 Further reading 4 External links See also Lysophospholipid receptor References ^ Entrez Gene: EDG8 endothelial differentiation, sphingolipid G-protein-coupled receptor, 8. Further reading Im DS, Heise CE, Ancellin N, et al. 2000. Characterization of a novel sphingosine 1-phosphate receptor, Edg-8.. J. Biol. Chem. 275 19: 14281-6. PMID 10799507. Malek RL, Toman RE, Edsall LC, et al. 2001. Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptors.. J. Biol. Chem. 276 8: 5692-9. doi:10.1074/jbc.M003964200. PMID 11069896. Hla T. Sphingosine 1-phosphate receptors. 64 1-4: 135-142. PMID 11331101. Im DS, Clemens J, Macdonald TL, Lynch KR 2001. Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 Edg-8: structure-activity relationship of sphingosine1-phosphate receptors.. Biochemistry 40 46: 14053-60. PMID 11705398. Takeda S, Kadowaki S, Haga T, et al. 2002. Identification of G protein-coupled receptor genes from the human genome sequence.. FEBS Lett. 520 1-3: 97-101. PMID 12044878. Niedernberg A, Scherer CR, Busch AE, Kostenis E 2002. Comparative analysis of human and rat S1P5 edg8: differential expression profiles and sensitivities to antagonists.. Biochem. Pharmacol. 64 8: 1243-50. PMID 12234605. Kothapalli R, Kusmartseva I, Loughran TP 2003. Characterization of a human sphingosine-1-phosphate receptor gene S1P5 and its differential expression in LGL leukemia.. Biochim. Biophys. Acta 1579 2-3: 117-23. PMID 12427546. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Vogler R, Sauer B, Kim DS, et al. 2003. Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing.. J. Invest. Dermatol. 120 4: 693-700. doi:10.1046/j.1523-1747.2003.12096.x. PMID 12648236. Ota T, Suzuki Y, Nishikawa T, et al. 2004. Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat. Genet. 36 1: 40-5. doi:10.1038/ng1285. PMID 14702039. Grimwood J, Gordon LA, Olsen A, et al. 2004. The DNA sequence and biology of human chromosome 19.. Nature 428 6982: 529-35. doi:10.1038/nature02399. PMID 15057824. Gerhard DS, Wagner L, Feingold EA, et al. 2004. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection MGC.. Genome Res. 14 10B: 2121-7. doi:10.1101/gr.2596504. PMID 15489334. Ulfig N, Briese M 2005. Evidence for the presence of the sphingosine-1-phosphate receptor Edg-8 in human radial glial fibers.. Acta Histochem. 106 5: 373-8. doi:10.1016/j.acthis.2004.08.002. PMID 15530552. Rual JF, Venkatesan K, Hao T, et al. 2005. Towards a proteome-scale map of the human protein-protein interaction network.. Nature 437 7062: 1173-8. doi:10.1038/nature04209. PMID 16189514. Otsuki T, Ota T, Nishikawa T, et al. 2007. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.. DNA Res. 12 2: 117-26. doi:10.1093/dnares/12.2.117. PMID 16303743. External links IUPHAR GPCR Database - Lysophospholipid receptors MeSH Lysophospholipid+receptors v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened This transmembrane receptor-related article is a stub. This article incorporates text from the United States National Library of Medicine, which is in the public domain. Retrieved from http://en..org/wiki/EDG8 Categories: Genes on chromosome 19 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 12:43
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