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14-September-2008 18:02:42 - Eicosanoid receptor An eicosanoid receptor is an integral membrane protein which detects the presence of eicosanoid signaling molecules. Most, though not all, are G protein-coupled receptors GPCRs. An example of a non-GPCR receptor that binds eicosanoids is PPAR-γ.1 The following is a list of the known human eicosanoid GPCRs grouped according to the type of eicosanoid ligand that each binds:23 Contents 1 Leukotriene 2 Lipoxin 3 Oxoeicosanoid 4 Prostanoid 5 References 6 External links Leukotriene Leukotrienes: CysLT1 Cysteinyl leukotriene receptor 1 - CYSLTR1 CysLT2 Cysteinyl leukotriene receptor 2 - CYSLTR2 BLT1 Leukotriene B4 receptor - LTB4R BLT2 Leukotriene B4 receptor 2 - LTB4R2 Lipoxin Lipoxins: LXA4R Formyl peptide receptor-like 1 - FPRL1 Oxoeicosanoid Oxoeicosanoid:4 Oxoeicosanoid OXE receptor 1 - OXER1 Prostanoid Prostanoids: PGD2: DP-PGD2 DP1 Prostaglandin D2 receptor - PTGDR DP2 GPR44 - GPR44 PGE2: EP1-PGE2 PTGER1 - PTGER1 EP2-PGE2 PTGER2 - PTGER2 EP3-PGE2 PTGER3 - PTGER3 EP4-PGE2 PTGER4 - PTGER4 PGF2α: FP-PGF2α PTGFR - PTGFR PGI2 prostacyclin: IP-PGI2 PTGIR - PTGIR TXA2 thromboxane: TP-TXA2 TBXA2R - TBXA2R References ^ DuBois RN, Gupta R, Brockman J, Reddy BS, Krakow SL, Lazar MA 1998. The nuclear eicosanoid receptor, PPAR-γ, is aberrantly expressed in colonic cancers. Carcinogenesis 19 1: 49-53. doi:10.1093/carcin/19.1.49. PMID 9472692. ^ Coleman RA, Smith WL, Narumiya S 1994. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol. Rev. 46 2: 205-29. PMID 7938166. ^ Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Nicosia S, Serhan CN, Shimizu T, Yokomizo T 2003. International Union of Pharmacology XXXVII. Nomenclature for leukotriene and lipoxin receptors. Pharmacol. Rev. 55 1: 195-227. doi:10.1124/pr.55.1.8. PMID 12615958. ^ Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Rovati GE, Serhan CN, Shimizu T, Yokomizo T 2004. International Union of Pharmacology XLIV. Nomenclature for the oxoeicosanoid receptor. Pharmacol. Rev. 56 1: 149-57. doi:10.1124/pr.56.1.4. PMID 15001665. External links IUPHAR GPCR Database - Leukotriene receptors IUPHAR GPCR Database - Prostanoid receptors MeSH Eicosanoid+receptors v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened v d e Membrane proteins, receptors: transmembrane receptors Asialoglycoprotein receptor - Autoreceptors - Biogenic amine receptor - Eicosanoid receptor Prostaglandin receptor - G protein-coupled receptor - Immune receptor - N-Acetylglucosamine receptor - Neuropilins - Neurotransmitter receptor - Olfactory receptor - Protease-activated receptor - Purinergic receptor - Transferrin receptor This biochemistry article is a stub. Retrieved from http://en..org/wiki/Eicosanoid_receptor Categories: G protein coupled receptors | Cell signaling | Signal transduction | Biochemistry stubs Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 19 February 2008, at 00:21
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