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14-September-2008 18:02:42 - RL3 Coagulation factor II thrombin receptor-like 3 Identifiers Symbols F2RL3; PAR4 External IDs OMIM: 602779 MGI: 1298207 HomoloGene: 36148 Gene ontology Molecular function: rhodopsin-like receptor activity receptor activity thrombin receptor activity Cellular component: plasma membrane integral to plasma membrane Biological process: signal transduction G-protein signaling, coupled to IP3 second messenger phospholipase C activating blood coagulation response to wounding RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 9002 14065 Ensembl ENSG00000127533 ENSMUSG00000050147 Uniprot Q96RI0 Q0VDX1 Refseq NM_003950 mRNA NP_003941 protein NM_007975 mRNA NP_032001 protein Location Chr 19: 16.86 - 16.87 Mb Chr 8: 75.66 - 75.66 Mb Pubmed search 1 2 Coagulation factor II thrombin receptor-like 3, also known as F2RL3 or protease activated receptor 4 PAR4, is a human gene.1 Coagulation factor II thrombin receptor-like 3 F2RL3 is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin.1 See also Protease-activated receptor References ^ a b Entrez Gene: F2RL3 coagulation factor II thrombin receptor-like 3. Further reading Leger AJ, Covic L, Kuliopulos A 2006. Protease-activated receptors in cardiovascular diseases.. Circulation 114 10: 1070-7. doi:10.1161/CIRCULATIONAHA.105.574830. PMID 16952995. Xu WF, Andersen H, Whitmore TE, et al. 1998. Cloning and characterization of human protease-activated receptor 4.. Proc. Natl. Acad. Sci. U.S.A. 95 12: 6642-6. PMID 9618465. Kahn ML, Zheng YW, Huang W, et al. 1998. A dual thrombin receptor system for platelet activation.. Nature 394 6694: 690-4. doi:10.1038/29325. PMID 9716134. Kahn ML, Hammes SR, Botka C, Coughlin SR 1998. Gene and locus structure and chromosomal localization of the protease-activated receptor gene family.. J. Biol. Chem. 273 36: 23290-6. PMID 9722561. Kahn ML, Nakanishi-Matsui M, Shapiro MJ, et al. 1999. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin.. J. Clin. Invest. 103 6: 879-87. PMID 10079109. Andersen H, Greenberg DL, Fujikawa K, et al. 1999. Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity.. Proc. Natl. Acad. Sci. U.S.A. 96 20: 11189-93. PMID 10500152. Page G, Kögel D, Rangnekar V, Scheidtmann KH 2000. Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis.. Oncogene 18 51: 7265-73. doi:10.1038/sj.onc.1203170. PMID 10602480. Sambrano GR, Huang W, Faruqi T, et al. 2000. Cathepsin G activates protease-activated receptor-4 in human platelets.. J. Biol. Chem. 275 10: 6819-23. PMID 10702240. Nakanishi-Matsui M, Zheng YW, Sulciner DJ, et al. 2000. PAR3 is a cofactor for PAR4 activation by thrombin.. Nature 404 6778: 609-13. doi:10.1038/35007085. PMID 10766244. Miike S, McWilliam AS, Kita H 2002. Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2.. J. Immunol. 167 11: 6615-22. PMID 11714832. Asokananthan N, Graham PT, Fink J, et al. 2002. Activation of protease-activated receptor PAR-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells.. J. Immunol. 168 7: 3577-85. PMID 11907122. Henriksen RA, Hanks VK 2002. PAR-4 agonist AYPGKF stimulates thromboxane production by human platelets.. Arterioscler. Thromb. Vasc. Biol. 22 5: 861-6. PMID 12006403. Covic L, Singh C, Smith H, Kuliopulos A 2003. Role of the PAR4 thrombin receptor in stabilizing platelet-platelet aggregates as revealed by a patient with Hermansky-Pudlak syndrome.. Thromb. Haemost. 87 4: 722-7. PMID 12008957. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Owen WG 2003. PAR-3 is a low-affinity substrate, high affinity effector of thrombin.. Biochem. Biophys. Res. Commun. 305 1: 166-8. PMID 12732212. Adam F, Verbeuren TJ, Fauchère JL, et al. 2003. Thrombin-induced platelet PAR4 activation: role of glycoprotein Ib and ADP.. J. Thromb. Haemost. 1 4: 798-804. PMID 12871418. Wu CC, Hwang TL, Liao CH, et al. 2004. The role of PAR4 in thrombin-induced thromboxane production in human platelets.. Thromb. Haemost. 90 2: 299-308. doi:10.1267/THRO03020299. PMID 12888878. Kawai T, Akira S, Reed JC 2003. ZIP kinase triggers apoptosis from nuclear PML oncogenic domains.. Mol. Cell. Biol. 23 17: 6174-86. PMID 12917339. Jacques SL, Kuliopulos A 2004. Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage.. Biochem. J. 376 Pt 3: 733-40. doi:10.1042/BJ20030954. PMID 13678420. Han Y, Nurden A, Combrié R, Pasquet JM 2004. Redistribution of glycoprotein Ib within platelets in response to protease-activated receptors 1 and 4: roles of cytoskeleton and calcium.. J. Thromb. Haemost. 1 10: 2206-15. PMID 14521606. This article incorporates text from the United States National Library of Medicine, which is in the public domain. This transmembrane receptor-related article is a stub. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/F2RL3 Categories: Genes on chromosome 19 | Human proteins | Transmembrane receptor stubs | Receptors | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 12:14
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