Sierra Acai Company
Sierra Acai Company
Open 7 Days a Week
MonaVie Independent Distributor
Distributor Training
Shop Online
Enroll Now
Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
Friends
Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
14-September-2008 18:02:42 - receptor 1 Formyl peptide receptor 1 Identifiers Symbols FPR1; FMLP; FPR External IDs OMIM: 136537 MGI: 107443 HomoloGene: 20466 Gene ontology Molecular function: rhodopsin-like receptor activity receptor activity N-formyl peptide receptor activity Cellular component: endosome plasma membrane integral to membrane Biological process: activation of MAPK activity cell motility chemotaxis inflammatory response signal transduction G-protein coupled receptor protein signaling pathway G-protein signaling, coupled to cAMP nucleotide second messenger nitric oxide mediated signal transduction RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 2357 14293 Ensembl ENSG00000171051 ENSMUSG00000045551 Uniprot P21462 Q3UV01 Refseq NM_002029 mRNA NP_002020 protein NM_013521 mRNA NP_038549 protein Location Chr 19: 56.94 - 56.95 Mb Chr 17: 17.58 - 17.59 Mb Pubmed search 1 2 Formyl peptide receptor 1, also known as FPR1, is a human gene.1 See also Formyl peptide receptor References ^ Entrez Gene: FPR1 formyl peptide receptor 1. Further reading Graves V, Gabig T, McCarthy L, et al. 1992. Simultaneous mobilization of Mac-1 CD11b/CD18 and formyl peptide chemoattractant receptors in human neutrophils.. Blood 80 3: 776-87. PMID 1322204. Murphy PM, Ozçelik T, Kenney RT, et al. 1992. A structural homologue of the N-formyl peptide receptor. Characterization and chromosome mapping of a peptide chemoattractant receptor family.. J. Biol. Chem. 267 11: 7637-43. PMID 1373134. Perez HD, Holmes R, Kelly E, et al. 1992. Cloning of the gene coding for a human receptor for formyl peptides. Characterization of a promoter region and evidence for polymorphic expression.. Biochemistry 31 46: 11595-9. PMID 1445895. Bao L, Gerard NP, Eddy RL, et al. 1992. Mapping of genes for the human C5a receptor C5AR, human FMLP receptor FPR, and two FMLP receptor homologue orphan receptors FPRH1, FPRH2 to chromosome 19.. Genomics 13 2: 437-40. PMID 1612600. Murphy PM, McDermott D 1991. Functional expression of the human formyl peptide receptor in Xenopus oocytes requires a complementary human factor.. J. Biol. Chem. 266 19: 12560-7. PMID 1712023. Boulay F, Tardif M, Brouchon L, Vignais P 1990. Synthesis and use of a novel N-formyl peptide derivative to isolate a human N-formyl peptide receptor cDNA.. Biochem. Biophys. Res. Commun. 168 3: 1103-9. PMID 2161213. Boulay F, Tardif M, Brouchon L, Vignais P 1991. The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors.. Biochemistry 29 50: 11123-33. PMID 2176894. Wahl SM, Allen JB, Gartner S, et al. 1989. HIV-1 and its envelope glycoprotein down-regulate chemotactic ligand receptors and chemotactic function of peripheral blood monocytes.. J. Immunol. 142 10: 3553-9. PMID 2541200. Jesaitis AJ, Naemura JR, Painter RG, et al. 1983. Intracellular localization of N-formyl chemotactic receptor and Mg2+ dependent ATPase in human granulocytes.. Biochim. Biophys. Acta 719 3: 556-68. PMID 6129903. Prossnitz ER, Kim CM, Benovic JL, Ye RD 1995. Phosphorylation of the N-formyl peptide receptor carboxyl terminus by the G protein-coupled receptor kinase, GRK2.. J. Biol. Chem. 270 3: 1130-7. PMID 7836371. Klotz KN, Jesaitis AJ 1994. Physical coupling of N-formyl peptide chemoattractant receptors to G protein is unaffected by desensitization.. Biochem. Pharmacol. 48 6: 1297-300. PMID 7945424. Bommakanti RK, Dratz EA, Siemsen DW, Jesaitis AJ 1994. Characterization of complex formation between Gi2 and octyl glucoside solubilized neutrophil N-formyl peptide chemoattractant receptor by sedimentation velocity.. Biochim. Biophys. Acta 1209 1: 69-76. PMID 7947984. Murphy PM, Tiffany HL, McDermott D, Ahuja SK 1993. Sequence and organization of the human N-formyl peptide receptor-encoding gene.. Gene 133 2: 285-90. PMID 8224916. Jesaitis AJ, Erickson RW, Klotz KN, et al. 1993. Functional molecular complexes of human N-formyl chemoattractant receptors and actin.. J. Immunol. 151 10: 5653-65. PMID 8228254. Särndahl E, Bokoch GM, Boulay F, et al. 1996. Direct or C5a-induced activation of heterotrimeric Gi2 proteins in human neutrophils is associated with interaction between formyl peptide receptors and the cytoskeleton.. J. Biol. Chem. 271 25: 15267-71. PMID 8663057. Maestes DC, Potter RM, Prossnitz ER 1999. Differential phosphorylation paradigms dictate desensitization and internalization of the N-formyl peptide receptor.. J. Biol. Chem. 274 42: 29791-5. PMID 10514456. Liang TS, Wang JM, Murphy PM, Gao JL 2000. Serum amyloid A is a chemotactic agonist at FPR2, a low-affinity N-formylpeptide receptor on mouse neutrophils.. Biochem. Biophys. Res. Commun. 270 2: 331-5. doi:10.1006/bbrc.2000.2416. PMID 10753626. Luu NT, Rainger GE, Nash GB 2000. Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils.. J. Immunol. 164 11: 5961-9. PMID 10820279. Bennett TA, Maestas DC, Prossnitz ER 2000. Arrestin binding to the G protein-coupled N-formyl peptide receptor is regulated by the conserved DRY sequence.. J. Biol. Chem. 275 32: 24590-4. doi:10.1074/jbc.C000314200. PMID 10823817. Ayala JM, Goyal S, Liverton NJ, et al. 2000. Serum-induced monocyte differentiation and monocyte chemotaxis are regulated by the p38 MAP kinase signal transduction pathway.. J. Leukoc. Biol. 67 6: 869-75. PMID 10857861. This transmembrane receptor-related article is a stub. This article incorporates text from the United States National Library of Medicine, which is in the public domain. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Formyl_peptide_receptor_1 Categories: Genes on chromosome 19 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 13:19
39 Reasons to Drink Acai Juice Every Day
What is MonaVie - Watch the 8-minute video
Discovering MonaVie Video
The Power of You Video
Effects of MonaVie Active on Antioxidant Capacity in Humans
Log into your Wholesale MonaVie Account
So many of us do not eat a balanced diet, get enough sleep, have too much stress, or are impacted with toxins and pollutants. Drinking 2 ounces of MonaVie twice a day will help your body detoxify as well as build your immune system. Its the smartest thing you can do for yourself, so start today. Buying MonaVie through our company guarantees you support 7 days a week and, if you would like to share MonaVie with your family and friends we will guide you from start to finish.
1. Click on Enroll Now (30 - 55% off retail price)
2. Pay $39 for your Wholesale ID number.
3. NO minimum order required.
4. MonaVie is delivered to your door in 3 to 5 days.