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14-September-2008 18:02:42 - 2 Formyl peptide receptor-like 2 Identifiers Symbols FPRL2; FPRH1; FPRH2; FML2_HUMAN; FMLPY; RMLP-R-I External IDs OMIM: 136539 MGI: 1194495 HomoloGene: 40605 Gene ontology Molecular function: rhodopsin-like receptor activity receptor activity N-formyl peptide receptor activity Cellular component: plasma membrane integral to membrane Biological process: cell motility chemotaxis signal transduction G-protein coupled receptor protein signaling pathway RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 2359 14294 Ensembl ENSG00000187474 n/a Uniprot P25089 n/a Refseq NM_002030 mRNA NP_002021 protein NM_008042 mRNA NP_032068 protein Location Chr 19: 56.99 - 57.02 Mb n/a Pubmed search 1 2 Formyl peptide receptor-like 2, also known as FPRL2, is a human gene.1 See also Formyl peptide receptor References ^ Entrez Gene: FPRL2 formyl peptide receptor-like 2. Further reading Bao L, Gerard NP, Eddy RL, et al. 1992. Mapping of genes for the human C5a receptor C5AR, human FMLP receptor FPR, and two FMLP receptor homologue orphan receptors FPRH1, FPRH2 to chromosome 19.. Genomics 13 2: 437-40. PMID 1612600. Durstin M, Gao JL, Tiffany HL, et al. 1994. Differential expression of members of the N-formylpeptide receptor gene cluster in human phagocytes.. Biochem. Biophys. Res. Commun. 201 1: 174-9. doi:10.1006/bbrc.1994.1685. PMID 8198572. Christophe T, Karlsson A, Dugave C, et al. 2001. The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2.. J. Biol. Chem. 276 24: 21585-93. doi:10.1074/jbc.M007769200. PMID 11285256. Yang D, Chen Q, Gertz B, et al. 2002. Human dendritic cells express functional formyl peptide receptor-like-2 FPRL2 throughout maturation.. J. Leukoc. Biol. 72 3: 598-607. PMID 12223529. Christophe T, Karlsson A, Rabiet MJ, et al. 2002. Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1/LXA4R, is not affected by lipoxin A4.. Scand. J. Immunol. 56 5: 470-6. PMID 12410796. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Ota T, Suzuki Y, Nishikawa T, et al. 2004. Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat. Genet. 36 1: 40-5. doi:10.1038/ng1285. PMID 14702039. Ernst S, Lange C, Wilbers A, et al. 2004. An annexin 1 N-terminal peptide activates leukocytes by triggering different members of the formyl peptide receptor family.. J. Immunol. 172 12: 7669-76. PMID 15187149. Harada M, Habata Y, Hosoya M, et al. 2004. N-Formylated humanin activates both formyl peptide receptor-like 1 and 2.. Biochem. Biophys. Res. Commun. 324 1: 255-61. doi:10.1016/j.bbrc.2004.09.046. PMID 15465011. Gerhard DS, Wagner L, Feingold EA, et al. 2004. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection MGC.. Genome Res. 14 10B: 2121-7. doi:10.1101/gr.2596504. PMID 15489334. Kang HK, Lee HY, Kim MK, et al. 2005. The synthetic peptide Trp-Lys-Tyr-Met-Val-D-Met inhibits human monocyte-derived dendritic cell maturation via formyl peptide receptor and formyl peptide receptor-like 2.. J. Immunol. 175 2: 685-92. PMID 16002663. Lee HY, Lee SY, Shin EH, et al. 2007. F2L, a peptide derived from heme-binding protein, inhibits formyl peptide receptor-mediated signaling.. Biochem. Biophys. Res. Commun. 359 4: 985-90. doi:10.1016/j.bbrc.2007.06.001. PMID 17577578. This transmembrane receptor-related article is a stub. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Formyl_peptide_receptor-like_2 Categories: Genes on chromosome 19 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 11:40
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