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14-September-2008 18:02:42 - GNRHR2 Gonadotropin-releasing hormone type 2 receptor 2 Identifiers Symbols GNRHR2; GnRH-II-R Gene ontology Molecular function: rhodopsin-like receptor activity receptor activity gonadotropin-releasing hormone receptor activity Cellular component: membrane integral to membrane Biological process: signal transduction G-protein coupled receptor protein signaling pathway Orthologs Human Mouse Entrez 114814 n/a Pubmed search 1 n/a Gonadotropin-releasing hormone type 2 receptor 2, also known as GNRHR2, is a human gene.1 The receptor for gonadotropin releasing hormone 2 GnRH2 is encoded by the GnRH2 receptor GnRHR2 gene. In non-hominoid primates and non-mammalian vertebrates, GnRHR2 encodes a seven-transmembrane G-protein coupled receptor. However, in human, the N-terminus of the predicted protein contains a frameshift and premature stop codon. In human, GnRHR2 transcription occurs but whether the gene produces a functional C-terminal multi-transmembrane protein is currently unresolved. Alternative splice variants have been reported. An untranscribed pseudogene of GnRHR2 is also on chromosome 14.1 See also Gonadotropin-releasing hormone receptor References ^ a b Entrez Gene: GNRHR2 gonadotropin-releasing hormone type 2 receptor 2. Further reading Neill JD 2002. GnRH and GnRH receptor genes in the human genome.. Endocrinology 143 3: 737-43. PMID 11861490. Millar R, Conklin D, Lofton-Day C, et al. 1999. A novel human GnRH receptor homolog gene: abundant and wide tissue distribution of the antisense transcript.. J. Endocrinol. 162 1: 117-26. PMID 10396028. Neill JD, Duck LW, Sellers JC, Musgrove LC 2001. A gonadotropin-releasing hormone GnRH receptor specific for GnRH II in primates.. Biochem. Biophys. Res. Commun. 282 4: 1012-8. doi:10.1006/bbrc.2001.4678. PMID 11352653. Faurholm B, Millar RP, Katz AA 2002. The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci.. Genomics 78 1-2: 15-8. doi:10.1006/geno.2001.6650. PMID 11707068. van Biljon W, Wykes S, Scherer S, et al. 2003. Type II gonadotropin-releasing hormone receptor transcripts in human sperm.. Biol. Reprod. 67 6: 1741-9. PMID 12444048. Morgan K, Conklin D, Pawson AJ, et al. 2003. A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12.. Endocrinology 144 2: 423-36. PMID 12538601. Pawson AJ, Maudsley S, Morgan K, et al. 2005. Inhibition of human type i gonadotropin-releasing hormone receptor GnRHR function by expression of a human type II GnRHR gene fragment.. Endocrinology 146 6: 2639-49. doi:10.1210/en.2005-0133. PMID 15761034. Eicke N, Günthert AR, Viereck V, et al. 2005. GnRH-II receptor-like antigenicity in human placenta and in cancers of the human reproductive organs.. Eur. J. Endocrinol. 153 4: 605-12. doi:10.1530/eje.1.02005. PMID 16189182. Ikemoto T, Park MK 2006. Comparative genomics of the endocrine systems in humans and chimpanzees with special reference to GNRH2 and UCN2 and their receptors.. Genomics 87 4: 459-62. doi:10.1016/j.ygeno.2005.11.005. PMID 16406723. Parker JD, Malik M, Catherino WH 2007. Human myometrium and leiomyomas express gonadotropin-releasing hormone 2 and gonadotropin-releasing hormone 2 receptor.. Fertil. Steril. 88 1: 39-46. doi:10.1016/j.fertnstert.2006.11.098. PMID 17296196. This transmembrane receptor-related article is a stub. This article incorporates text from the United States National Library of Medicine, which is in the public domain. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/GNRHR2 Categories: Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 12:52
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