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14-September-2008 18:02:43 - 9 G protein-coupled receptor 39 Identifiers Symbols GPR39; MGC149541 External IDs OMIM: 602886 MGI: 1918361 HomoloGene: 20380 Gene ontology Molecular function: rhodopsin-like receptor activity receptor activity Cellular component: integral to plasma membrane membrane Biological process: signal transduction G-protein coupled receptor protein signaling pathway RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 2863 71111 Ensembl ENSG00000183840 ENSMUSG00000026343 Uniprot O43194 Q9D442 Refseq NM_001508 mRNA NP_001499 protein XM_913690 mRNA XP_918783 protein Location Chr 2: 132.89 - 133.12 Mb Chr 1: 127.5 - 127.7 Mb Pubmed search 1 2 G protein-coupled receptor 39, also known as GPR39, is a human gene.1 References ^ Entrez Gene: GPR39 G protein-coupled receptor 39. Further reading Bonaldo MF, Lennon G, Soares MB 1997. Normalization and subtraction: two approaches to facilitate gene discovery.. Genome Res. 6 9: 791-806. PMID 8889548. McKee KK, Tan CP, Palyha OC, et al. 1998. Cloning and characterization of two human G protein-coupled receptor genes GPR38 and GPR39 related to the growth hormone secretagogue and neurotensin receptors.. Genomics 46 3: 426-34. doi:10.1006/geno.1997.5069. PMID 9441746. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Ota T, Suzuki Y, Nishikawa T, et al. 2004. Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat. Genet. 36 1: 40-5. doi:10.1038/ng1285. PMID 14702039. Holst B, Holliday ND, Bach A, et al. 2005. Common structural basis for constitutive activity of the ghrelin receptor family.. J. Biol. Chem. 279 51: 53806-17. doi:10.1074/jbc.M407676200. PMID 15383539. Gerhard DS, Wagner L, Feingold EA, et al. 2004. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection MGC.. Genome Res. 14 10B: 2121-7. doi:10.1101/gr.2596504. PMID 15489334. Hillier LW, Graves TA, Fulton RS, et al. 2005. Generation and annotation of the DNA sequences of human chromosomes 2 and 4.. Nature 434 7034: 724-31. doi:10.1038/nature03466. PMID 15815621. Kimura K, Wakamatsu A, Suzuki Y, et al. 2006. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.. Genome Res. 16 1: 55-65. doi:10.1101/gr.4039406. PMID 16344560. Holst B, Egerod KL, Schild E, et al. 2007. GPR39 signaling is stimulated by zinc ions but not by obestatin.. Endocrinology 148 1: 13-20. doi:10.1210/en.2006-0933. PMID 16959833. Lauwers E, Landuyt B, Arckens L, et al. 2006. Obestatin does not activate orphan G protein-coupled receptor GPR39.. Biochem. Biophys. Res. Commun. 351 1: 21-5. doi:10.1016/j.bbrc.2006.09.141. PMID 17054911. Egerod KL, Holst B, Petersen PS, et al. 2007. GPR39 splice variants versus antisense gene LYPD1: expression and regulation in gastrointestinal tract, endocrine pancreas, liver, and white adipose tissue.. Mol. Endocrinol. 21 7: 1685-98. doi:10.1210/me.2007-0055. PMID 17488974. Yasuda S, Miyazaki T, Munechika K, et al. 2007. Isolation of Zn2+ as an endogenous agonist of GPR39 from fetal bovine serum.. J. Recept. Signal Transduct. Res. 27 4: 235-46. doi:10.1080/10799890701506147. PMID 17885920. This transmembrane receptor-related article is a stub. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/GPR39 Categories: Genes on chromosome 2
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