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14-September-2008 18:02:43 - G protein-coupled receptor 4 Identifiers Symbols GPR4; External IDs OMIM: 600551 MGI: 2441992 HomoloGene: 3867 Gene ontology Molecular function: rhodopsin-like receptor activity receptor activity Cellular component: integral to plasma membrane membrane Biological process: signal transduction G-protein coupled receptor protein signaling pathway RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 2828 319197 Ensembl ENSG00000177464 ENSMUSG00000044317 Uniprot P46093 n/a Refseq NM_005282 mRNA NP_005273 protein NM_175668 mRNA NP_783599 protein Location Chr 19: 50.78 - 50.8 Mb Chr 7: 18.37 - 18.38 Mb Pubmed search 1 2 G protein-coupled receptor 4, also known as GPR4, is a human gene.1 References ^ Entrez Gene: GPR4 G protein-coupled receptor 4. Further reading An S, Tsai C, Goetzl EJ 1996. Cloning, sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue.. FEBS Lett. 375 1-2: 121-4. PMID 7498459. Heiber M, Docherty JM, Shah G, et al. 1995. Isolation of three novel human genes encoding G protein-coupled receptors.. DNA Cell Biol. 14 1: 25-35. PMID 7832990. Mahadevan MS, Baird S, Bailly JE, et al. 1996. Isolation of a novel G protein-coupled receptor GPR4 localized to chromosome 19q13.3.. Genomics 30 1: 84-8. doi:10.1006/geno.1995.0013. PMID 8595909. Zhu K, Baudhuin LM, Hong G, et al. 2001. Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4.. J. Biol. Chem. 276 44: 41325-35. doi:10.1074/jbc.M008057200. PMID 11535583. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Lum H, Qiao J, Walter RJ, et al. 2003. Inflammatory stress increases receptor for lysophosphatidylcholine in human microvascular endothelial cells.. Am. J. Physiol. Heart Circ. Physiol. 285 4: H1786-9. doi:10.1152/ajpheart.00359.2003. PMID 12805023. Ludwig MG, Vanek M, Guerini D, et al. 2003. Proton-sensing G-protein-coupled receptors.. Nature 425 6953: 93-8. doi:10.1038/nature01905. PMID 12955148. Bektas M, Barak LS, Jolly PS, et al. 2003. The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner.. Biochemistry 42 42: 12181-91. doi:10.1021/bi035051y. PMID 14567679. Sin WC, Zhang Y, Zhong W, et al. 2004. G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers.. Oncogene 23 37: 6299-303. doi:10.1038/sj.onc.1207838. PMID 15221007. Gerhard DS, Wagner L, Feingold EA, et al. 2004. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection MGC.. Genome Res. 14 10B: 2121-7. doi:10.1101/gr.2596504. PMID 15489334. Kim KS, Ren J, Jiang Y, et al. 2005. GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine.. FASEB J. 19 7: 819-21. doi:10.1096/fj.04-2988fje. PMID 15857892. Qiao J, Huang F, Naikawadi RP, et al. 2006. Lysophosphatidylcholine impairs endothelial barrier function through the G protein-coupled receptor GPR4.. Am. J. Physiol. Lung Cell Mol. Physiol. 291 1: L91-101. doi:10.1152/ajplung.00508.2005. PMID 16461426. Huang F, Mehta D, Predescu S, et al. 2007. A novel lysophospholipid- and pH-sensitive receptor, GPR4, in brain endothelial cells regulates monocyte transmigration.. Endothelium 14 1: 25-34. doi:10.1080/10623320601177288. PMID 17364894. Zou Y, Kim CH, Chung JH, et al. 2007. Upregulation of endothelial adhesion molecules by lysophosphatidylcholine. Involvement of G protein-coupled receptor GPR4.. FEBS J. 274 10: 2573-84. doi:10.1111/j.1742-4658.2007.05792.x. PMID 17437524. Tobo M, Tomura H, Mogi C, et al. 2007. Previously postulated ligand-independent signaling of GPR4 is mediated through proton-sensing mechanisms.. Cell. Signal. 19 8: 1745-53. doi:10.1016/j.cellsig.2007.03.009. PMID 17462861. This transmembrane receptor-related article is a stub. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/GPR4 Categories: Genes on chromosome 19 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 11:41
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