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14-September-2008 18:02:43 - 6 G protein-coupled receptor 56 Identifiers Symbols GPR56; BFPP; DKFZp781L1398; TM7LN4; TM7XN1 External IDs OMIM: 604110 MGI: 1340051 HomoloGene: 4156 Gene ontology Molecular function: receptor activity G-protein coupled receptor activity protein binding Cellular component: integral to plasma membrane membrane Biological process: cell adhesion signal transduction neuropeptide signaling pathway cell-cell signaling brain development RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 9289 14766 Ensembl ENSG00000205336 ENSMUSG00000031785 Uniprot Q9Y653 Q8K209 Refseq NM_005682 mRNA NP_005673 protein NM_018882 mRNA NP_061370 protein Location Chr 16: 56.24 - 56.26 Mb Chr 8: 97.87 - 97.9 Mb Pubmed search 1 2 G protein-coupled receptor 56, also known as GPR56, is a human gene.1 References ^ Entrez Gene: GPR56 G protein-coupled receptor 56. Further reading Xu L, Hynes RO 2007. GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironment.. Cell Cycle 6 2: 160-5. PMID 17314516. Liu M, Parker RM, Darby K, et al. 1999. GPR56, a novel secretin-like human G-protein-coupled receptor gene.. Genomics 55 3: 296-305. doi:10.1006/geno.1998.5644. PMID 10049584. Zendman AJ, Cornelissen IM, Weidle UH, et al. 1999. TM7XN1, a novel human EGF-TM7-like cDNA, detected with mRNA differential display using human melanoma cell lines with different metastatic potential.. FEBS Lett. 446 2-3: 292-8. PMID 10100861. Piao X, Basel-Vanagaite L, Straussberg R, et al. 2002. An autosomal recessive form of bilateral frontoparietal polymicrogyria maps to chromosome 16q12.2-21.. Am. J. Hum. Genet. 70 4: 1028-33. PMID 11845408. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Clark HF, Gurney AL, Abaya E, et al. 2003. The secreted protein discovery initiative SPDI, a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.. Genome Res. 13 10: 2265-70. doi:10.1101/gr.1293003. PMID 12975309. Little KD, Hemler ME, Stipp CS 2005. Dynamic regulation of a GPCR-tetraspanin-G protein complex on intact cells: central role of CD81 in facilitating GPR56-Galpha q/11 association.. Mol. Biol. Cell 15 5: 2375-87. doi:10.1091/mbc.E03-12-0886. PMID 15004227. Piao X, Hill RS, Bodell A, et al. 2004. G protein-coupled receptor-dependent development of human frontal cortex.. Science 303 5666: 2033-6. doi:10.1126/science.1092780. PMID 15044805. Zhang Z, Henzel WJ 2005. Signal peptide prediction based on analysis of experimentally verified cleavage sites.. Protein Sci. 13 10: 2819-24. doi:10.1110/ps.04682504. PMID 15340161. Gerhard DS, Wagner L, Feingold EA, et al. 2004. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection MGC.. Genome Res. 14 10B: 2121-7. doi:10.1101/gr.2596504. PMID 15489334. Shashidhar S, Lorente G, Nagavarapu U, et al. 2005. GPR56 is a GPCR that is overexpressed in gliomas and functions in tumor cell adhesion.. Oncogene 24 10: 1673-82. doi:10.1038/sj.onc.1208395. PMID 15674329. Sud N, Sharma R, Ray R, et al. 2006. Differential expression of G-protein coupled receptor 56 in human esophageal squamous cell carcinoma.. Cancer Lett. 233 2: 265-70. doi:10.1016/j.canlet.2005.03.018. PMID 15916848. Otsuki T, Ota T, Nishikawa T, et al. 2007. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.. DNA Res. 12 2: 117-26. doi:10.1093/dnares/12.2.117. PMID 16303743. Xu L, Begum S, Hearn JD, Hynes RO 2006. GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis.. Proc. Natl. Acad. Sci. U.S.A. 103 24: 9023-8. doi:10.1073/pnas.0602681103. PMID 16757564. This transmembrane receptor-related article is a stub. This article incorporates text from the United States National Library of Medicine, which is in the public domain. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/GPR56 Categories: Genes on chromosome 16 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 13:11
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