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14-September-2008 18:02:43 - 8 G protein-coupled receptor 98 Identifiers Symbols GPR98; USH2B; DKFZp761P0710; FEB4; KIAA0686; MASS1; USH2C; VLGR1; VLGR1b External IDs OMIM: 602851 MGI: 1274784 HomoloGene: 19815 Gene ontology Molecular function: receptor activity G-protein coupled receptor activity calcium ion binding Cellular component: membrane integral to membrane Biological process: cell communication signal transduction neuropeptide signaling pathway nervous system development visual perception sensory perception of sound cell-cell adhesion response to stimulus RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 84059 110789 Ensembl ENSG00000164199 ENSMUSG00000069170 Uniprot Q8WXG9 Q8C1E5 Refseq NM_032119 mRNA NP_115495 protein NM_054053 mRNA NP_473394 protein Location Chr 5: 89.95 - 90.5 Mb Chr 13: 81.56 - 82.07 Mb Pubmed search 1 2 G protein-coupled receptor 98, also known as GPR98, is a human protein and gene.1 This gene encodes a member of the G-protein coupled receptor superfamily. The protein binds calcium and is expressed in the central nervous system. It is also known as very large G-protein coupled receptor 1 because it is 6300 residues long. It contains a C-terminal 7-transmembrane receptor domain, whereas the large N-terminal segment 5900 residues includes 35 calcium binding Calx-beta domains, and 6 EAR domains. Mutations in this gene are associated with Usher syndrome 2 and familial febrile seizures. Several alternatively spliced transcripts have been described.1 References ^ a b Entrez Gene: GPR98 G protein-coupled receptor 98. Further reading Nakajima D, Okazaki N, Yamakawa H, et al. 2003. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.. DNA Res. 9 3: 99-106. PMID 12168954. Staub E, Pérez-Tur J, Siebert R, et al. 2002. The novel EPTP repeat defines a superfamily of proteins implicated in epileptic disorders.. Trends Biochem. Sci. 27 9: 441-4. PMID 12217514. Ishikawa K, Nagase T, Suyama M, et al. 1998. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.. DNA Res. 5 3: 169-76. PMID 9734811. Nakayama J, Hamano K, Iwasaki N, et al. 2000. Significant evidence for linkage of febrile seizures to chromosome 5q14-q15.. Hum. Mol. Genet. 9 1: 87-91. PMID 10587582. Pieke-Dahl S, Möller CG, Kelley PM, et al. 2000. Genetic heterogeneity of Usher syndrome type II: localisation to chromosome 5q.. J. Med. Genet. 37 4: 256-62. PMID 10745043. Nikkila H, McMillan DR, Nunez BS, et al. 2001. Sequence similarities between a novel putative G protein-coupled receptor and Na+/Ca2+ exchangers define a cation binding domain.. Mol. Endocrinol. 14 9: 1351-64. PMID 10976914. Wiemann S, Weil B, Wellenreuther R, et al. 2001. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.. Genome Res. 11 3: 422-35. doi:10.1101/gr.154701. PMID 11230166. Skradski SL, Clark AM, Jiang H, et al. 2001. A novel gene causing a mendelian audiogenic mouse epilepsy.. Neuron 31 4: 537-44. PMID 11545713. McMillan DR, Kayes-Wandover KM, Richardson JA, White PC 2002. Very large G protein-coupled receptor-1, the largest known cell surface protein, is highly expressed in the developing central nervous system.. J. Biol. Chem. 277 1: 785-92. doi:10.1074/jbc.M108929200. PMID 11606593. Nagase T, Kikuno R, Ohara O 2002. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins.. DNA Res. 8 6: 319-27. PMID 11853319. Nakayama J, Fu YH, Clark AM, et al. 2002. A nonsense mutation of the MASS1 gene in a family with febrile and afebrile seizures.. Ann. Neurol. 52 5: 654-7. doi:10.1002/ana.10347. PMID 12402266. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Ota T, Suzuki Y, Nishikawa T, et al. 2004. Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat. Genet. 36 1: 40-5. doi:10.1038/ng1285. PMID 14702039. Weston MD, Luijendijk MW, Humphrey KD, et al. 2004. Mutations in the VLGR1 gene implicate G-protein signaling in the pathogenesis of Usher syndrome type II.. Am. J. Hum. Genet. 74 2: 357-66. PMID 14740321. Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. 2005. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.. Genomics 84 1: 23-33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201. Fu GK, Wang JT, Yang J, et al. 2005. Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.. Genomics 84 1: 205-10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218. Schwartz SB, Aleman TS, Cideciyan AV, et al. 2005. Disease expression in Usher syndrome caused by VLGR1 gene mutation USH2C and comparison with USH2A phenotype.. Invest. Ophthalmol. Vis. Sci. 46 2: 734-43. doi:10.1167/iovs.04-1136. PMID 15671307. Kimura K, Wakamatsu A, Suzuki Y, et al. 2006. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.. Genome Res. 16 1: 55-65. doi:10.1101/gr.4039406. PMID 16344560. This transmembrane receptor-related article is a stub. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/GPR98 Categories: Genes on chromosome 5 | Human proteins | Transmembrane receptor stubs | Receptors | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 10:49
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