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14-September-2008 18:02:43 - GPRC6A G protein-coupled receptor, family C, group 6, member A Identifiers Symbols GPRC6A; GPCR; bA86F4.3 External IDs MGI: 2429498 HomoloGene: 17529 Gene ontology Molecular function: receptor activity metabotropic glutamate, GABA-B-like receptor activity Cellular component: cell surface membrane integral to membrane Biological process: signal transduction G-protein coupled receptor protein signaling pathway calcium-mediated signaling Orthologs Human Mouse Entrez 222545 210198 Ensembl ENSG00000173612 ENSMUSG00000019905 Uniprot Q5T6X5 Q8K4Z6 Refseq NM_148963 mRNA NP_683766 protein NM_153071 mRNA NP_694711 protein Location Chr 6: 117.22 - 117.26 Mb Chr 10: 51.3 - 51.32 Mb Pubmed search 1 2 G protein-coupled receptor, family C, group 6, member A, also known as GPRC6A, is a human gene.1 This receptor functions as a sensor of L-amino acids.2 References ^ Entrez Gene: GPRC6A G protein-coupled receptor, family C, group 6, member A. ^ Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Bräuner-Osborne H 2005. Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids. Mol. Pharmacol. 67 3: 589-97. doi:10.1124/mol.104.007559. PMID 15576628. Further reading Harrington JJ, Sherf B, Rundlett S, et al. 2001. Creation of genome-wide protein expression libraries using random activation of gene expression.. Nat. Biotechnol. 19 5: 440-5. doi:10.1038/88107. PMID 11329013. Takeda S, Kadowaki S, Haga T, et al. 2002. Identification of G protein-coupled receptor genes from the human genome sequence.. FEBS Lett. 520 1-3: 97-101. PMID 12044878. Mungall AJ, Palmer SA, Sims SK, et al. 2003. The DNA sequence and analysis of human chromosome 6.. Nature 425 6960: 805-11. doi:10.1038/nature02055. PMID 14574404. Wellendorph P, Bräuner-Osborne H 2004. Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor.. Gene 335: 37-46. doi:10.1016/j.gene.2004.03.003. PMID 15194188. Wellendorph P, Hansen KB, Balsgaard A, et al. 2005. Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids.. Mol. Pharmacol. 67 3: 589-97. doi:10.1124/mol.104.007559. PMID 15576628. Pi M, Faber P, Ekema G, et al. 2006. Identification of a novel extracellular cation-sensing G-protein-coupled receptor.. J. Biol. Chem. 280 48: 40201-9. doi:10.1074/jbc.M505186200. PMID 16199532. External links IUPHAR GPCR Database - GPRC6 MeSH GPRC6A+protein,+human v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened This transmembrane receptor-related article is a stub. Retrieved from http://en..org/wiki/GPRC6A Categories: Genes on chromosome 6 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 9 July 2008, at 06:07
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