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14-September-2008 18:02:43 - 3 Galanin receptor 3 Identifiers Symbols GALR3; External IDs OMIM: 603692 MGI: 1329003 HomoloGene: 20798 Gene ontology Molecular function: rhodopsin-like receptor activity receptor activity galanin receptor activity Cellular component: plasma membrane integral to membrane Biological process: signal transduction negative regulation of adenylate cyclase activity neuropeptide signaling pathway synaptic transmission learning and/or memory feeding behavior RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 8484 14429 Ensembl ENSG00000128310 ENSMUSG00000047429 Uniprot O60755 O88853 Refseq NM_003614 mRNA NP_003605 protein XM_001001042 mRNA XP_001001042 protein Location Chr 22: 36.55 - 36.55 Mb Chr 15: 78.87 - 78.87 Mb Pubmed search 1 2 Galanin receptor 3, also known as GALR3, is a human gene.1 The neuropeptide galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior. The human galanin receptors are G protein-coupled receptors that functionally couple to their intracellular effector through distinct signaling pathways. GALR3 is found in many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts1 See also Galanin receptor References ^ a b Entrez Gene: GALR3 galanin receptor 3. Further reading Smith KE, Walker MW, Artymyshyn R, et al. 1998. Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.. J. Biol. Chem. 273 36: 23321-6. PMID 9722565. Kolakowski LF, O'Neill GP, Howard AD, et al. 1998. Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3.. J. Neurochem. 71 6: 2239-51. PMID 9832121. Iismaa TP, Fathi Z, Hort YJ, et al. 1999. Structural organization and chromosomal localization of three human galanin receptor genes.. Ann. N. Y. Acad. Sci. 863: 56-63. PMID 9928159. Lapsys NM, Furler SM, Henderson NK, et al. 1999. A polymorphism in the human GALR3 galanin receptor gene GALNR3.. Mol. Cell. Probes 13 4: 325-7. doi:10.1006/mcpr.1999.0254. PMID 10441207. Dunham I, Shimizu N, Roe BA, et al. 1999. The DNA sequence of human chromosome 22.. Nature 402 6761: 489-95. doi:10.1038/990031. PMID 10591208. Berger A, Tuechler C, Almer D, et al. 2002. Elevated expression of galanin receptors in childhood neuroblastic tumors.. Neuroendocrinology 75 2: 130-8. PMID 11867941. Belfer I, Hipp H, Bollettino A, et al. 2007. Alcoholism is associated with GALR3 but not two other galanin receptor genes.. Genes Brain Behav. 6 5: 473-81. doi:10.1111/j.1601-183X.2006.00275.x. PMID 17083333. This transmembrane receptor-related article is a stub. This article incorporates text from the United States National Library of Medicine, which is in the public domain. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Galanin_receptor_3 Categories: Genes on chromosome 22
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