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14-September-2008 18:02:43 - polypeptide receptor Gastric inhibitory polypeptide receptor Identifiers Symbols GIPR; MGC126722 External IDs OMIM: 137241 MGI: 1352753 HomoloGene: 20081 Gene ontology Molecular function: G-protein coupled receptor activity gastric inhibitory peptide receptor activity Cellular component: plasma membrane integral to membrane Biological process: generation of precursor metabolites and energy G-protein coupled receptor protein signaling pathway adenylate cyclase activation response to nutrient RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 2696 381853 Ensembl ENSG00000010310 ENSMUSG00000030406 Uniprot P48546 n/a Refseq NM_000164 mRNA NP_000155 protein XM_133238 mRNA XP_133238 protein Location Chr 19: 50.86 - 50.88 Mb Chr 7: 18.32 - 18.32 Mb Pubmed search 1 2 Gastric inhibitory polypeptide receptors GIPRs are seven-transmembrane proteins found on beta-cells in the pancreas.12 They bind gastric inhibitory polypeptide. References ^ Gastrointestinal Hormones and Peptides. Retrieved on 2007-08-24. ^ Brubaker PL, Drucker DJ 2002. Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors dead link - Scholar search. Recept. Channels 8 3-4: 179-88. PMID 12529935. Retrieved on 2007-08-24. Further reading Yamada Y, Seino Y 2005. Physiology of GIP--a lesson from GIP receptor knockout mice.. Horm. Metab. Res. 36 11-12: 771-4. doi:10.1055/s-2004-826162. PMID 15655707. Stoffel M, Fernald AA, Le Beau MM, Bell GI 1996. Assignment of the gastric inhibitory polypeptide receptor gene GIPR to chromosome bands 19q13.2-q13.3 by fluorescence in situ hybridization.. Genomics 28 3: 607-9. doi:10.1006/geno.1995.1203. PMID 7490109. Gremlich S, Porret A, Hani EH, et al. 1995. Cloning, functional expression, and chromosomal localization of the human pancreatic islet glucose-dependent insulinotropic polypeptide receptor.. Diabetes 44 10: 1202-8. PMID 7556958. Volz A, Göke R, Lankat-Buttgereit B, et al. 1995. Molecular cloning, functional expression, and signal transduction of the GIP-receptor cloned from a human insulinoma.. FEBS Lett. 373 1: 23-9. PMID 7589426. Usdin TB, Mezey E, Button DC, et al. 1994. Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain.. Endocrinology 133 6: 2861-70. PMID 8243312. Yamada Y, Hayami T, Nakamura K, et al. 1996. Human gastric inhibitory polypeptide receptor: cloning of the gene GIPR and cDNA.. Genomics 29 3: 773-6. doi:10.1006/geno.1995.9937. PMID 8575774. Gallwitz B, Witt M, Morys-Wortmann C, et al. 1997. GLP-1/GIP chimeric peptides define the structural requirements for specific ligand-receptor interaction of GLP-1.. Regul. Pept. 63 1: 17-22. PMID 8795084. N'Diaye N, Tremblay J, Hamet P, et al. 1998. Adrenocortical overexpression of gastric inhibitory polypeptide receptor underlies food-dependent Cushing's syndrome.. J. Clin. Endocrinol. Metab. 83 8: 2781-5. PMID 9709947. Tseng CC, Zhang XY 2000. Role of G protein-coupled receptor kinases in glucose-dependent insulinotropic polypeptide receptor signaling.. Endocrinology 141 3: 947-52. PMID 10698169. Bollag RJ, Zhong Q, Phillips P, et al. 2000. Osteoblast-derived cells express functional glucose-dependent insulinotropic peptide receptors.. Endocrinology 141 3: 1228-35. PMID 10698200. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Baldacchino V, Oble S, Hamet P, et al. 2003. Partial characterisation of the 5' flanking region of the human GIP receptor GIPR gene.. Endocr. Res. 28 4: 577. PMID 12530665. Antonini SR, N'Diaye N, Hamet P, et al. 2003. Analysis of the putative promoter region of the GIP receptor gene GIPR in GIP-dependent Cushing's syndrome CS.. Endocr. Res. 28 4: 755-6. PMID 12530694. Manhart S, Hinke SA, McIntosh CH, et al. 2003. Structure-function analysis of a series of novel GIP analogues containing different helical length linkers.. Biochemistry 42 10: 3081-8. doi:10.1021/bi026868e. PMID 12627975. Ding KH, Zhong Q, Isales CM 2003. Glucose-dependent insulinotropic peptide stimulates thymidine incorporation in endothelial cells: role of endothelin-1.. Am. J. Physiol. Endocrinol. Metab. 285 2: E390-6. doi:10.1152/ajpendo.00509.2002. PMID 12721154. Grimwood J, Gordon LA, Olsen A, et al. 2004. The DNA sequence and biology of human chromosome 19.. Nature 428 6982: 529-35. doi:10.1038/nature02399. PMID 15057824. Hansotia T, Baggio LL, Delmeire D, et al. 2004. Double incretin receptor knockout DIRKO mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors.. Diabetes 53 5: 1326-35. PMID 15111503. Gerhard DS, Wagner L, Feingold EA, et al. 2004. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection MGC.. Genome Res. 14 10B: 2121-7. doi:10.1101/gr.2596504. PMID 15489334. Baldacchino V, Oble S, Hamet P, et al. 2005. The Sp transcription factor family is involved in the cellular expression of the human GIP-R gene promoter.. Endocr. Res. 30 4: 805-6. PMID 15666829. External links IUPHAR GPCR Database - GIP receptor MeSH gastric+inhibitory+polypeptide+receptor This transmembrane receptor-related article is a stub. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Gastric_inhibitory_polypeptide_receptor Categories: Genes on chromosome 19 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden categories: All articles with dead external links | Articles with dead external links since June 2008 | Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 04:2
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