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14-September-2008 18:02:39 - General anaesthesia In modern medical practice, general anaesthesia AmE: anesthesia is a state of total unconsciousness resulting from general anaesthetic drugs. A variety of drugs are given to the patient that have different effects with the overall aim of ensuring unconsciousness, amnesia, analgesia and paralysis. The anaesthetist AmE: anesthesiologist, if a medical doctor, nurse anesthetist if an advanced clinical practitioner who does not hold a medical degree; CRNA=certified registered nurse anesthetist, or dental anesthesiologist if a dentist who has completed a specialty training program in anesthesia, selects the optimal technique for any given patient and procedure. Medicine or the Medicine Portal may be able to help recruit one. If a more appropriate or portal exists, please adjust this template accordingly. Contents 1 Overview 2 Preanaesthetic evaluation 3 Stages of anaesthesia 3.1 Stage 1 3.2 Stage 2 3.3 Stage 3 3.4 Stage 4 4 Postoperative Analgesia 5 Mortality rates 6 See also 7 Notes 8 External links Overview General anaesthesia is a complex procedure involving: Preanaesthetic assessment Administration of general anaesthetic drugs Cardiorespiratory monitoring Analgesia Airway management Fluid management Postoperative pain relief Preanaesthetic evaluation Prior to surgery, the anaesthetist interviews the patient to determine the best combination of drugs and dosages and the degree of monitoring required to ensure a safe and effective procedure. Pertinent information is the patient's age, weight, medical history, current medications, previous anaesthetics, and fasting time. Usually, the patients are required to fill out this information on a separate form during the pre-operative evaluation. Depending on the existing medical conditions reported, the anaesthetist will review this information with the patient either during his pre-operative evaluation or on the day of his or her surgery. Truthful and accurate answering of the questions is important so the anaesthetist can select the proper anaesthetics. For instance, a heavy drinker or drug user who does not disclose their chemical uses could be undermedicated, which could then lead to anesthesia awareness or dangerously high blood pressure. Commonly used medications such as Viagra can interact with anaesthesia drugs; failure to disclose such usage can endanger the patient. An important aspect of this assessment is that of the patient's airway, involving inspection of the mouth opening and visualisation of the soft tissues of the pharynx. The condition of teeth and location of dental crowns and caps are checked, neck flexibility and head extension observed. If an endotracheal tube is indicated and airway management is deemed difficult, then alternative placement methods such as fiberoptic intubation may be used. Stages of anaesthesia The progression of stages described here was devised for anaesthesia using diethyl ether and is largely replaced by the 3 stage classification. Stage 1 Stage 1 anaesthesia, also known as the induction, is the period between the initial administration of the induction medications and loss of consciousness. During this stage the patient progresses from analgesia without amnesia to analgesia with amnesia. Patients can carry on a conversation at the time. Stage 2 Stage 2 anesthesia, also known as the excitement stage, is the period following loss of consciousness and marked by excited and delirious activity. During this stage, respirations and heart rate may become irregular. In addition, there may be uncontrolled movements, vomiting, breath holding, and pupillary dilation. Since the combination of spastic movements, vomiting, and irregular respirations may lead to airway compromise, rapidly acting drugs are used to minimize time in this stage and reach stage 3 as fast as possible. Stage 3 Stage Three: during this stage excitement disappears, respiration becomes regular, the pulse slows down, and reflexes disappear. the 3rd stage of anaesthesia is divided into 4 planes. plane i - reflexes controlling voluntary muscles begin to go, pupil diameter return to initial size plane ii - respiration becomes more regular and the eyelid reflexes are abolished. plane iii- there is an incomplete intercostal paralysis. thoracic movement is reduced and lags behind abdominal movement. surgery is normally carried out at this stage. plane iv - there is a complete intercostal paralysis. the purely abdominal breathing is rapid and shallow, pupil dilate, the cough and vomiting centres in the medulla are depressed Stage 4 Stage 4 anaesthesia, also known as overdose, is the stage where too much medication has been given and the patient has severe brain stem or medullary depression. This results in a cessation of respiration and potential cardiovascular collapse. This stage is lethal without cardiovascular and respiratory support. Postoperative Analgesia The anaesthesia concludes with a management plan for postoperative pain relief. This may be in the form of regional analgesia, oral, transdermal or parenteral medication. Minor surgical procedures are amenable to oral pain relief medications such as paracetamol and NSAIDS such as ibuprofen. Moderate levels of pain require the addition of mild opiates such as codeine. Major surgical procedures may require a combination of modalities to confer adequate pain relief. Parenteral methods include Patient Controlled Analgesia System PCAS involving morphine, a strong opiate. Here, the patient presses a button to activate a pump containing morphine. This administers a preset dose of the drug. As the pump is programmed not to exceed a safe amount of the drug, the patient cannot self administer a toxic dose. Mortality rates In the US, up until about 1980 anesthesia was a significant risk, with at least one death per 10,000 times administered.1 After becoming something of a public scandal, a careful effort was made to understand the causes and improve the results.2 It is generally believed that anesthesia is now at least ten times safer than it was then.3 However, there is some controversy about this.4 In the US, the data is not made public in fact, the data is not even collected, so the truth is uncertain.5 The rate for dental anesthesia is reported to be one out of 350,000.6 Death during anaesthesia is most commonly related to surgical factors or pre-existing medical conditionscitation needed. These include major haemorrhage, sepsis, and organ failure eg. heart, lungs, kidneys, liver. Common causes of death directly related to anaesthesia includecitation needed: aspiration of stomach contents suffocation due to inadequate airway management allergic reactions to anaesthesia specifically and not limited to anti-nausea agents and other deadly genetic predispositions human error equipment failure See also Anaesthetic equipment intraoperative awareness Notes External links Chloroform: The molecular lifesaverAn article at Oxford University providing interesting facts about chloroform. Australian New Zealand College of Anaesthetists Monitoring Standard Royal College of Anaesthetists Patient Information page v d e Major drug groups Gastrointestinal tract/metabolism A stomach acid Antacids, H2 antagonists, Proton pump inhibitors Antiemetics Laxatives Antidiarrhoeals/Antipropulsives Anti-obesity drugs Anti-diabetics Vitamins Dietary minerals Blood and blood forming organs B Antithrombotics Anticoagulants, Antiplatelets, Thrombolytics Antihemorrhagics Cardiovascular system C cardiac therapy/antianginals Cardiac glycosides, Antiarrhythmics, Cardiac stimulant Antihypertensives Diuretics Vasodilators Beta blockers renin-angiotensin system ACE inhibitors, Angiotensin II receptor antagonists, Renin inhibitors Antihyperlipidemics Skin D Emollients Cicatrizant Antipruritics Reproductive system G Hormonal contraception Fertility agents SERMs Sex hormones Endocrine system H Corticosteroids Sex hormones Thyroid hormones Antithyroid agent Infections and infestations J, P Antibiotics Antivirals Vaccines Antifungals Antiparasitic Antiprotozoals, Anthelmintics Malignant and immune disease L Anticancer agents Immunostimulators Immunosuppressants Muscles, bones, and joints M Anabolic steroids Anti-inflammatories NSAID Antirheumatics Corticosteroids Muscle relaxants Brain and nervous system N Anesthetics General, Local Analgesics Anticonvulsants Mood stabilizers Psycholeptic Anxiolytics, Antipsychotics, Hypnotics/Sedatives Psychoanaleptic Antidepressants, Stimulants/Psychostimulants Respiratory system R Bronchodilators Decongestants H1 antagonists Other ATC V Antidotes Contrast media Radiopharmaceuticals Dressing v d e Anesthetic: General anesthetics N01A Inhalation Ethers Diethyl ether, Methoxypropane, Vinyl ether, halogenated ethers Desflurane, Enflurane, Isoflurane, Methoxyflurane, Sevoflurane Haloalkanes Chloroform, Halothane, Trichloroethylene Other Nitrous oxide, Xenon, Cyclopropane Injection Barbiturates Hexobarbital, Methohexital, Narcobarbital, Thiopental Opioids Alfentanil, Anileridine, Fentanyl, Phenoperidine, Remifentanil, Sufentanil Steroid Alfaxalone, Minaxolone Others Droperidol, Ethylene, Etomidate, Fospropofol, gamma-Hydroxybutyric acid, Ketamine/Esketamine, Propanidid, Propofol Retrieved from http://en..org/wiki/General_anaesthesia Categories: AnesthesiaHidden categories: Medicine articles needing expert attention | Articles needing expert attention | Pages needing expert attention | All articles with statements | Articles with statements since July 2008 Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Türkçe Dansk Deutsch Français Italiano ქáƒ?რთული Nederlands 日本語 Polski РуÑ?Ñ?кий Suomi Svenska Türkçe This page was last modified on 12 August 2008, at 20:20
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