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14-September-2008 18:02:43 - 2 receptor Glucagon-like peptide 2 receptor Identifiers Symbols GLP2R; External IDs OMIM: 603659 MGI: 2136733 HomoloGene: 3132 Gene ontology Molecular function: receptor activity G-protein coupled receptor activity Cellular component: plasma membrane membrane integral to membrane Biological process: signal transduction G-protein coupled receptor protein signaling pathway G-protein signaling, coupled to cAMP nucleotide second messenger positive regulation of cell proliferation RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 9340 93896 Ensembl ENSG00000065325 n/a Uniprot O95838 n/a Refseq NM_004246 mRNA NP_004237 protein XM_991784 mRNA XP_996878 protein Location Chr 17: 9.67 - 9.73 Mb n/a Pubmed search 1 2 The gene for the glucagon-like peptide 2 receptor GLP-2 is on chromosome 17.1 Contents 1 See also 2 References 3 Further reading 4 External links See also Glucagon-like peptide-2 References ^ Brubaker PL, Drucker DJ 2002. Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors dead link - Scholar search. Recept. Channels 8 3-4: 179-88. PMID 12529935. Retrieved on 2007-08-24. Further reading Burrin DG, Petersen Y, Stoll B, Sangild P 2001. Glucagon-like peptide 2: a nutrient-responsive gut growth factor.. J. Nutr. 131 3: 709-12. PMID 11238747. Munroe DG, Gupta AK, Kooshesh F, et al. 1999. Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2.. Proc. Natl. Acad. Sci. U.S.A. 96 4: 1569-73. PMID 9990065. Yusta B, Huang L, Munroe D, et al. 2000. Enteroendocrine localization of GLP-2 receptor expression in humans and rodents.. Gastroenterology 119 3: 744-55. PMID 10982769. Thulesen J, Knudsen LB, Hartmann B, et al. 2002. The truncated metabolite GLP-2 3-33 interacts with the GLP-2 receptor as a partial agonist.. Regul. Pept. 103 1: 9-15. PMID 11738243. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Koehler JA, Yusta B, Drucker DJ 2005. The HeLa cell glucagon-like peptide-2 receptor is coupled to regulation of apoptosis and ERK1/2 activation through divergent signaling pathways.. Mol. Endocrinol. 19 2: 459-73. doi:10.1210/me.2004-0196. PMID 15471943. Ørskov C, Hartmann B, Poulsen SS, et al. 2005. GLP-2 stimulates colonic growth via KGF, released by subepithelial myofibroblasts with GLP-2 receptors.. Regul. Pept. 124 1-3: 105-12. doi:10.1016/j.regpep.2004.07.009. PMID 15544847. Mahon MJ, Shimada M 2005. Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors.. FEBS Lett. 579 3: 803-7. doi:10.1016/j.febslet.2004.12.056. PMID 15670850. Estall JL, Koehler JA, Yusta B, Drucker DJ 2005. The glucagon-like peptide-2 receptor C terminus modulates beta-arrestin-2 association but is dispensable for ligand-induced desensitization, endocytosis, and G-protein-dependent effector activation.. J. Biol. Chem. 280 23: 22124-34. doi:10.1074/jbc.M500078200. PMID 15817468. Guan X, Karpen HE, Stephens J, et al. 2006. GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow.. Gastroenterology 130 1: 150-64. doi:10.1053/j.gastro.2005.11.005. PMID 16401478. Sams A, Hastrup S, Andersen M, Thim L 2006. Naturally occurring glucagon-like peptide-2 GLP-2 receptors in human intestinal cell lines.. Eur. J. Pharmacol. 532 1-2: 18-23. doi:10.1016/j.ejphar.2005.12.001. PMID 16448646. External links IUPHAR GPCR Database - GLP-2 receptor MeSH glucagon-like+peptide+receptor This transmembrane receptor-related article is a stub. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Glucagon-like_peptide_2_receptor Categories: Genes on chromosome 17 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden categories: All articles with dead external links | Articles with dead external links since June 2008 | Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 05:34
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