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14-September-2008 18:02:43 - receptor Glucagon receptor Identifiers Symbols GCGR; GGR; MGC138246 External IDs OMIM: 138033 MGI: 99572 HomoloGene: 131 Gene ontology Molecular function: receptor activity G-protein coupled receptor activity glucagon receptor activity Cellular component: plasma membrane integral to membrane Biological process: generation of precursor metabolites and energy signal transduction G-protein coupled receptor protein signaling pathway G-protein signaling, coupled to cAMP nucleotide second messenger response to nutrient blood pressure regulation Orthologs Human Mouse Entrez 2642 14527 Ensembl n/a ENSMUSG00000025127 Uniprot n/a Q3UN81 Refseq NM_000160 mRNA NP_000151 protein NM_008101 mRNA NP_032127 protein Location n/a Chr 11: 120.35 - 120.36 Mb Pubmed search 1 2 The glucagon receptor is a 62 kDa peptide that is activated by glucagon and is a member of the G-protein coupled family of receptors, coupled to Gs.1 Stimulation of the receptor results in activation of adenylate cyclase and increased levels of intracellular cAMP. Glucagon receptors are mainly expressed in liver and in kidney with lesser amounts found in heart, adipose tissue, spleen, thymus, adrenal glands, pancreas, cerebral cortex, and gastrointestinal tract. References ^ Brubaker PL, Drucker DJ 2002. Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors dead link. Recept. Channels 8 3-4: 179-88. PMID 12529935. Retrieved on 2007-08-24. Further reading Levey GS, Weiss SR, Ruiz E 1975. Characterization of the glucagon receptor in a pheochromocytoma.. J. Clin. Endocrinol. Metab. 40 4: 720-3. PMID 165216. Nakamura S, Rodbell M 1991. Glucagon induces disaggregation of polymer-like structures of the alpha subunit of the stimulatory G protein in liver membranes.. Proc. Natl. Acad. Sci. U.S.A. 88 16: 7150-4. PMID 1908089. Horuk R, Wright DE 1983. Partial purification and characterization of the glucagon receptor.. FEBS Lett. 155 2: 213-7. PMID 6303843. MacNeil DJ, Occi JL, Hey PJ, et al. 1994. Cloning and expression of a human glucagon receptor.. Biochem. Biophys. Res. Commun. 198 1: 328-34. doi:10.1006/bbrc.1994.1046. PMID 7507321. Fujisawa T, Ikegami H, Yamato E, et al. 1995. A mutation in the glucagon receptor gene Gly40Ser: heterogeneity in the association with diabetes mellitus.. Diabetologia 38 8: 983-5. PMID 7589886. Hager J, Hansen L, Vaisse C, et al. 1995. A missense mutation in the glucagon receptor gene is associated with non-insulin-dependent diabetes mellitus.. Nat. Genet. 9 3: 299-304. doi:10.1038/ng0395-299. PMID 7773293. Menzel S, Stoffel M, Espinosa R, et al. 1994. Localization of the glucagon receptor gene to human chromosome band 17q25.. Genomics 20 2: 327-8. doi:10.1006/geno.1994.1179. PMID 8020989. Lok S, Kuijper JL, Jelinek LJ, et al. 1994. The human glucagon receptor encoding gene: structure, cDNA sequence and chromosomal localization.. Gene 140 2: 203-9. PMID 8144028. Unson CG, Macdonald D, Merrifield RB 1993. The role of histidine-1 in glucagon action.. Arch. Biochem. Biophys. 300 2: 747-50. doi:10.1006/abbi.1993.1103. PMID 8382034. Chambers SM, Morris BJ 1996. Glucagon receptor gene mutation in essential hypertension.. Nat. Genet. 12 2: 122. doi:10.1038/ng0296-122. PMID 8563746. Yamato E, Ikegami H, Takekawa K, et al. 1997. Tissue-specific and glucose-dependent expression of receptor genes for glucagon and glucagon-like peptide-1 GLP-1.. Horm. Metab. Res. 29 2: 56-9. PMID 9105899. Strazzullo P, Iacone R, Siani A, et al. 2001. Altered renal sodium handling and hypertension in men carrying the glucagon receptor gene Gly40Ser variant.. J. Mol. Med. 79 10: 574-80. doi:10.1007/s001090100257. PMID 11692154. Shiota D, Kasamatsu T, Dib SA, et al. 2002. Role of the Gly40Ser mutation in the glucagon receptor gene in Brazilian patients with type 2 diabetes mellitus.. Pancreas 24 4: 386-90. PMID 11961492. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Runge S, Gram C, Brauner-Osborne H, et al. 2003. Three distinct epitopes on the extracellular face of the glucagon receptor determine specificity for the glucagon amino terminus.. J. Biol. Chem. 278 30: 28005-10. doi:10.1074/jbc.M301085200. PMID 12724331. Hassel S, Eichner A, Yakymovych M, et al. 2004. Proteins associated with type II bone morphogenetic protein receptor BMPR-II and identified by two-dimensional gel electrophoresis and mass spectrometry.. Proteomics 4 5: 1346-58. doi:10.1002/pmic.200300770. PMID 15188402. Gerhard DS, Wagner L, Feingold EA, et al. 2004. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection MGC.. Genome Res. 14 10B: 2121-7. doi:10.1101/gr.2596504. PMID 15489334. Mortensen OH, Dichmann DS, Abrahamsen N, et al. 2007. Identification of a novel human glucagon receptor promoter: regulation by cAMP and PGC-1alpha.. Gene 393 1-2: 127-36. doi:10.1016/j.gene.2007.01.023. PMID 17374560. External links IUPHAR Receptor Database - Glucagon Receptor v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened This transmembrane receptor-related article is a stub. Retrieved from http://en..org/wiki/Glucagon_receptor Categories: Human proteins | G protein coupled receptors | Transmembrane receptor stubsHidden categories: All articles with dead external links | Articles with dead external links since May 2008 | Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 02:46
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